<i>Candida auris</i>Invasive Infections during a COVID-19 Case Surge

Hanson, Blake; Dinh, An Q; Tran, Truc T.; Arenas, Sebastian; Pronty, Darryl; Gershengorn, Hayley B.; Ferreira, Tanira; Arias, César A.; Shukla, Bhavarth

doi:10.1128/aac.01146-21

Cited by 53 publications

(42 citation statements)

References 7 publications

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“…Among the opportunistic infections in COVID-19 patients, a higher incidence of fungal co-infections was observed [112][113][114][115]. Most fungalrelated co-infections in COVID-19 patients involved Aspergillus spp., C. albicans, C. auris, C. dubliniensis, C. glabrata, C. tropicalis, C. krusei, and C. parapsilosis sensu stricto [116,117].…”

Section: Candida and Other Fungal Infections In Covid-19mentioning

confidence: 99%

Fungal Colonization and Infections—Interactions with Other Human Diseases

2022

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Candida albicans is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infections to fulminant sepsis with 70% mortality rates. Fungi influence at least several diseases, in part by mechanisms such as the production of pro-carcinogenic agents, molecular mimicking, and triggering of the inflammation cascade. These processes impact the interactions among human pathogenic and resident fungi, the bacteriome in various organs/tissues, and the host immune system, dictating the outcomes of invasive infections, metabolic diseases, and cancer. Although mechanistic investigations are at stages of infancy, recent studies have advanced our understanding of host–fungal interactions, their role in immune homeostasis, and their associated pathologies. This review summarizes the role of C. albicans and other opportunistic fungi, specifically their association with various diseases, providing a glimpse at the recent developments and our current knowledge in the context of inflammatory-bowel disease (IBD), cancers, and COVID-19. Two of the most common human diseases where fungal interactions have been previously well-studied are cancer and IBD. Here we also discuss the emerging role of fungi in the ongoing and evolving pandemic of COVID-19, as it is relevant to current health affairs.

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Section: Candida and Other Fungal Infections In Covid-19mentioning

confidence: 99%

Fungal Colonization and Infections—Interactions with Other Human Diseases

2022

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“…Outbreaks of Candida auris have been reported post-COVID-19 in many countries including four South American countries and Arab countries such as Lebanon where this fungus had never been isolated in the pre-COVID-19 era [ 63 ]. This is likely due to overconsumption of antimicrobial agents, particularly antifungal drugs, as well as poor infection control practices during the pandemic [ 63 , 64 , 65 , 66 ]. More recently, mucormycosis has emerged as an important and deadly co-infection in India and some countries of the Americas [ 67 ].…”

Section: The Covid-19 Pandemic: What Do We Know?mentioning

confidence: 99%

Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions

et al. 2021

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The COVID-19 pandemic is expected to worsen the global problem of antimicrobial resistance (AMR). There is a heightened interest in understanding this effect and to develop antimicrobial stewardship (AMS) interventions accordingly to curb this threat. Our paper aims to evaluate the potential magnitude of COVID-19 on AMR and AMS with a focus on the countries of the Arab league, given the social, political, and economic environments. We also evaluate obstacles in applying the rational use of antibiotics, monitoring resistance trends in the midst of the pandemic, and evaluating the impact of the economic crisis in some countries. We aim to raise awareness about the potential effects of antibiotic overuse during the pandemic and to propose practical approaches to tackle this issue.

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“…Critically-ill COVID-19 patients with ARDS are also reported to be more susceptible to fungal super-infections caused by Candida species and Aspergillus fumigatus . 7 , 8 Invasion of internal organs by Candida species might occur in patients with severe COVID-19 due to excessive use of antibiotics and corticosteroids, and central venous catheter, coupled with the complications caused by severe ARDS coronavirus 2 (SARS CoV-2). 9 Besides candidiasis and aspergillosis, occurrence of mucormycosis (also known as “black fungus”) has been reported recently in Asian countries (mostly in India) among patients affected with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Candida Pneumonia with Lung Abscess as a Complication of Severe COVID-19 Pneumonia

Abdelhadi¹,

Kassem²

2021

IMCRJ

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A South Asian male patient in his mid-forties presented with symptoms of severe 2019-nCoV (COVID-19) and recent brain infarction. Subsequently, he was found to have evidence of sepsis, underlying undetected diabetes mellitus (DM) and oral candida mucositis, possibly leading to the rare occurrence of direct spread to the lung, manifesting as a necrotizing candida lung abscess. We describe the diagnosis, clinical course, and management of the unique complication in this case that occurred during his admission, hospitalization, and eventual successful discharge from the hospital. This case highlights the importance of early identification and treatment of suspected COVID-19 infection based on clinical and radiological assessments before the confirmation of COVID-19 by real-time polymerase chain reaction (rtPCR) test result, especially in patients with hyperglycemia. It also indicates the complications that can occur due to COVID-19 such as arteriovenous manifestations and the rare occurrence of pulmonary candida lung abscess. Early detection and prompt management by interdisciplinary teams in the emergency room, followed by close monitoring of complications in the intensive care unit (ICU), can lead to successful outcomes in severe/critical COVID-19 infection.

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Candida aurisInvasive Infections during a COVID-19 Case Surge

Cited by 53 publications

References 7 publications

Fungal Colonization and Infections—Interactions with Other Human Diseases

Fungal Colonization and Infections—Interactions with Other Human Diseases

Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions

Candida Pneumonia with Lung Abscess as a Complication of Severe COVID-19 Pneumonia

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