<i>Candida blankii</i>
            : an emergent opportunistic yeast with reduced susceptibility to antifungals

Almeida, João Nóbrega de; Campos, Sílvia Vidal; Thomaz, Danilo Yamamoto; Thomaz, Luciana Costa Lima; Almeida, Renato K. G. de; Negro, G. Del; Gimenes, Viviane F.; Grenfell, Rafaella C.; Motta, Adriana; Rossi, Flávia; Benard, Gil

doi:10.1038/s41426-017-0015-8

Cited by 17 publications

(22 citation statements)

References 13 publications

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“…3 (A) and (B)). Although no approved susceptibility breakpoints for C. blankii are yet available, our susceptibility results to antifungal agents are comparable with a previous report [2] . Because the isolate showed reduced susceptibility to fluconazole by Etest (≥12 μg/mL) and VITEK 2 identified it as S .…”

Section: Resultssupporting

confidence: 89%

“…The isolate (Kw593/18) was unequivocally identified as C. blankii because the ITS region of rDNA (GenBank accession no. LT993736) exhibited 100% sequence identity with the corresponding sequence from type strain (CBS1898) as well as several other (CBS6427, CBS7205, CBS1989 and CBS6788) strains, and only one nucleotide difference with a bloodstream isolate (HCFMUSP01) of C. blankii obtained from a cystic fibrosis patient in Brazil [2] . The ITS region of rDNA sequences from C. blankii CBS1898, C. blankii CBS6427 and several other closely related species [6] , as well as sequences from other well-known pathogenic Candida spp.…”

Section: Resultsmentioning

confidence: 95%

“…C. blankii was first described from blood of a mink in 1968 by Buckley and van Uden [7] . Two other studies have also described the isolation of this yeast from clinical specimens, including bloodstream of a fungaemia patient [1] , [2] .…”

Section: Discussionmentioning

confidence: 99%

“…Therapeutic experience with C. blankii fungaemia is limited to only one previous case [2] . The patient experienced clearing the yeast from blood after 3 days of micafungin therapy and was discharged after 14 days of maintenance therapy with no postinfection complication.…”

Section: Discussionmentioning

confidence: 99%

“…The first report described its isolation from respiratory specimens of a patient with repeated exacerbations of cystic fibrosis [1] . The second patient, also with cystic fibrosis, yielded a germ-tube–negative Candida species along with Aspergillus [2] . This patient was receiving itraconazole when the sputum culture yielded this yeast.…”

Section: Introductionmentioning

confidence: 99%

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Azole-resistant Candida blankii as a newly recognized cause of bloodstream infection

Al-Haqqan¹,

Al‐Sweih

Ahmad

et al. 2018

New Microbes and New Infections

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Candida blankii is a newly recognized human pathogen. Here we describe a case of bloodstream infection in a preterm neonate. The yeast was repeatedly isolated from blood, and its identity was confirmed by PCR sequencing of rDNA. Additionally, C. blankii DNA was detected directly in a blood sample. The isolates initially developed pink colonies on CHROMagar Candida which later turned into dark metallic blue similar to Candida tropicalis. Inaccurate identification by the VITEK 2 yeast identification system as Stephanoascus ciferrii and intrinsic resistance to fluconazole (MIC 12–16 μg/mL) underscore the need for its accurate identification for appropriate therapeutic management.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Azole-resistant Candida blankii as a newly recognized cause of bloodstream infection

Al-Haqqan¹,

Al‐Sweih

Ahmad

et al. 2018

New Microbes and New Infections

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Candida , Cryptococcus , and Other Yeasts of Medical Importance

Borman,

Johnson

2023

ClinMicroNow

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Unicellular fungi which typically divide by budding have traditionally been referred to as yeasts. The rapidly expanding use of molecular identification strategies has permitted detailed phylogenetic analyses, allowing more accurate delineation of taxonomic boundaries and the reclassification of many yeast species and genera. Molecular identification approaches have also further added to the taxonomic complexity via the delineation of a number of cryptic species and species complexes in many traditional Candida species that can be separated only based on DNA sequencing analysis. The heterogeneous genus Candida belongs to the order Saccharomycetales within the ascomycetes. Rhodotorula spp. and species in the allied genus Cystobasidium share many similar physiologic and morphologic properties with Cryptococcus spp., as they are round to oval‐shaped, multilateral budding yeasts with capsules, although capsules, when present, are typically small. Carbohydrate antigens have provided useful targets for several commercial kits for the detection of disseminated candidiasis.

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The yeast genus Tardiomyces gen. nov. with one new species and two new combinations

Spruijtenburg,

de Souza Lima,

Tosar

et al. 2024

Infection

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Purpose Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals. Methods To obtain more insight into the characteristics of this species, 26 isolates reported as C. blankii were investigated using genetic and phenotypical approaches. Results Among the 26 isolates, seven recovered either from blood, sputum, urine, or the oral cavity, displayed substantial genetic and some phenotypical differences compared to the other isolates, which were confirmed as C. blankii. We consider these seven strains to represent a novel species, Tardiomyces depauwii. Phylogenomics assigned C. blankii, C. digboiensis, and the novel species in a distinct branch within the order Dipodascales, for which the novel genus Tardiomyces is erected. The new combinations Tardiomyces blankii and Tardiomyces digboiensis are introduced. Differences with related, strictly environmental genera Sugiyamaella, Crinitomyces, and Diddensiella are enumerated. All three Tardiomyces species share the rare ability to grow up to 42 °C, display slower growth in nutrient-poor media, and show a reduced susceptibility to azoles and echinocandins. Characteristics of T. depauwii include high MIC values with voriconazole and a unique protein pattern. Conclusion We propose the novel yeast species Tardiomyces depauwii and the transfer of C. blankii and C. digboiensis to the novel Tardiomyces genus.

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Candida blankii : an emergent opportunistic yeast with reduced susceptibility to antifungals

Cited by 17 publications

References 13 publications

Azole-resistant Candida blankii as a newly recognized cause of bloodstream infection

Azole-resistant Candida blankii as a newly recognized cause of bloodstream infection

Candida , Cryptococcus , and Other Yeasts of Medical Importance

The yeast genus Tardiomyces gen. nov. with one new species and two new combinations

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