<i>Candida utilis</i> fungaemia following endoscopic intervention on ureteral stent in a kidney transplant recipient: Case report and a review of the literature

Gaisne, Raphaël; Jeddi, Fakhri; Morio, Florent; Clerc, Q. Le; Hourmant, Maryvonne; Blancho, Gilles; Giral, Magali; Cantarovich, Diego; Dantal, Jacques; Ville, Simon

doi:10.1111/myc.12766

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Surprisingly, we isolated emerging Candida species, namely C. dubliniensis , C. fabianii , C. utilis , C. eremophila and C. melibiosica , from infected paediatric patients, which have also been previously isolated in other countries. In agreement with other studies, the majority of these emerging Candida species showed reduced susceptibility to antifungal agents . Uncommon Candida species often go undetected in routine microbiology laboratories, and the clinical significance of these species remains underestimated.…”

Section: Discussionmentioning

confidence: 99%

“…In agreement with other studies, the majority of these emerging Candida species showed reduced susceptibility to antifungal agents. 22,[30][31][32][33] Uncommon Candida species often go undetected in routine microbiology laboratories, and the clinical significance of these species remains underestimated. In developing countries, considering the lack of adequate facilities in hospital laboratories, identification of Candida species is limited to conventional methods.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran

Ahangarkani

Shokohi

Rezai

et al. 2020

Mycoses

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Summary Nosocomial bloodstream candidaemia is a life‐threatening fungal infection with high morbidity and mortality, especially among paediatric patients undergoing intensive immunosuppressive therapy. Limited data on the epidemiology of candidaemia and susceptibility profiles are available for Iran. To characterise candidaemia epidemiology, comorbidity risk factors, species distribution, and antifungal susceptibility profiles among paediatric patients in Iran. This observational cross‐sectional study enrolled 26 189 patients <18 years old at three reference paediatric hospitals in Mazandaran and Tehran over 2 years. Blood samples from patients with suspected fungal bloodstream infection were analysed using the BACTEC culture system. Fungal isolates were identified using matrix‐assisted laser desorption ionisation time‐of‐flight mass spectrometry (MALDI‐TOF) and DNA sequencing. Antifungal susceptibility testing was performed using the Clinical and Laboratory Standards Institute broth microdilution guideline. We observed 109 episodes of nosocomial candidaemia in paediatric patients with or without immunosuppressive therapy. The most common healthcare‐associated factor was central vascular catheter use (97%). The all‐cause mortality rate was 40%, of which 48% was attributable to candidaemia. While Candida albicans was the most frequent causative agent (49%), emerging and uncommon Candida species were also isolated. Candidaemia mortality by non‐albicans Candida species was significantly higher than that by C. albicans (P < .05). All fluconazole‐resistant species were non‐albicans Candida species. Uncommon Candida species with reduced susceptibility to antifungals are emerging as major agents of nosocomial candidaemia in high‐risk paediatric patients in Iran. Appropriate source control, antifungal regimens and improved antifungal stewardship are warranted for managing and decreasing the burden of nosocomial candidaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran

Ahangarkani

Shokohi

Rezai

et al. 2020

Mycoses

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“…Previous studies have analyzed the genome sequences and RNA-seq to identify genes involved in nitrate assimilation and functional hexose transporters ( Tomita et al, 2012 ; Gaisne et al, 2018 ; Ding et al, 2023 ). Transcriptome analysis in C. utilis during selenium enrichment reveals the underlying mechanisms responsible for enhanced intracellular organic selenium and glutathione biosynthesis and secretion ( Zhang et al, 2017 , 2019 ).…”

Section: Discussionmentioning

confidence: 99%

An integrated transcriptomic and metabolic phenotype analysis to uncover the metabolic characteristics of a genetically engineered Candida utilis strain expressing δ-zein gene

He,

Gong,

Wan

et al. 2023

Front. Microbiol.

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IntroductionCandida utilis (C. utilis) has been extensively utilized as human food or animal feed additives. With its ability to support heterologous gene expression, C. utilis proves to be a valuable platform for the synthesis of proteins and metabolites that possess both high nutritional and economic value. However, there remains a dearth of research focused on the characteristics of C. utilis through genomic, transcriptomic and metabolic approaches.MethodsWith the aim of unraveling the molecular mechanism and genetic basis governing the biological process of C. utilis, we embarked on a de novo sequencing endeavor to acquire comprehensive sequence data. In addition, an integrated transcriptomic and metabolic phenotype analysis was performed to compare the wild-type C. utilis (WT) with a genetically engineered strain of C. utilis that harbors the heterologous δ-zein gene (RCT).Resultsδ-zein is a protein rich in methionine found in the endosperm of maize. The integrated analysis of transcriptomic and metabolic phenotypes uncovered significant metabolic diversity between the WT and RCT C. utilis. A total of 252 differentially expressed genes were identified, primarily associated with ribosome function, peroxisome activity, arginine and proline metabolism, carbon metabolism, and fatty acid degradation. In the experimental setup using PM1, PM2, and PM4 plates, a total of 284 growth conditions were tested. A comparison between the WT and RCT C. utilis demonstrated significant increases in the utilization of certain carbon source substrates by RCT. Gelatin and glycogen were found to be significantly utilized to a greater extent by RCT compared to WT. Additionally, in terms of sulfur source substrates, RCT exhibited significantly increased utilization of O-Phospho-L-Tyrosine and L-Methionine Sulfone when compared to WT.DiscussionThe introduction of δ-zein gene into C. utilis may lead to significant changes in the metabolic substrates and metabolic pathways, but does not weaken the activity of the strain. Our study provides new insights into the transcriptomic and metabolic characteristics of the genetically engineered C. utilis strain harboring δ-zein gene, which has the potential to advance the utilization of C. utilis as an efficient protein feed in agricultural applications.

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“…The literature search, study selection and collective expert evaluation will be repeated every 6 months. Denis et al (2018), Gaisne et al (2018), Li et al (2018), Mount et al (2018), Musatti et al (2018), Mixao and Gabaldon (2018), Robledo-Leal et al (2018), Rosenberg et al (2018), Scott et al (2018), Steenkamp et al (2018), Steenkamp et al (2018), Phadke et al (2018), Sivamaruthi (2018), Wayakanon et al (2018) Relevant to the QPS exercise…”

Section: B6mentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 9: suitability of taxonomic units notified to EFSA until September 2018

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2019

EFS2

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The qualified presumption of safety (QPS) procedure was developed to provide a harmonised generic pre‐evaluation to support safety risk assessments of biological agents performed by EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance were assessed. Safety concerns identified for a taxonomic unit are, where possible and reasonable in number, reflected by ‘qualifications’ which should be assessed at the strain level by the EFSA's Scientific Panels. During the current assessment, no new information was found that would change the previously recommended QPS taxonomic units and their qualifications. Between April and September 2018, the QPS notification list was updated with 48 microorganisms from applications for market authorisation. Of these, 30 biological agents already had QPS status, 15 were excluded from the QPS exercise by the previous QPS mandate (five filamentous fungi) or from further evaluations within the current mandate (two notifications of Enterococcus faecium, one of Streptomyces spp. and seven of Escherichia coli). One taxonomic unit was (re)evaluated: Pseudomonas fluorescens had been previously evaluated in 2016, and was now re‐evaluated within this mandate. The revision of the literature supports the previously identified safety concerns (e.g. production of biocompounds with antimicrobial activity and virulence features), preventing the inclusion of P. fluorescens in the QPS list. Mycobacterium setense and Komagataeibacter sucrofermentans were evaluated for the first time. M. setense cannot be considered for the QPS assessment because there are significant safety concerns. K. sucrofermentans (Acetobacter xylinus subsp. sucrofermentans) can be proposed for the QPS list but only for production purposes. The QPS status of Corynebacterium glutamicum is confirmed with the qualification extended to other production purposes.

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Candida utilis fungaemia following endoscopic intervention on ureteral stent in a kidney transplant recipient: Case report and a review of the literature

Cited by 7 publications

References 20 publications

Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran

Epidemiological features of nosocomial candidaemia in neonates, infants and children: A multicentre study in Iran

An integrated transcriptomic and metabolic phenotype analysis to uncover the metabolic characteristics of a genetically engineered Candida utilis strain expressing δ-zein gene

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 9: suitability of taxonomic units notified to EFSA until September 2018

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