<i>Capnocytophaga canimorsus</i>– a potent pathogen in immunocompetent humans – systematic review and retrospective observational study of case reports

Mader, Naomi; Lührs, Fabian; Langenbeck, Martin; Herget–Rosenthal, Stefan

doi:10.1080/23744235.2019.1687933

Cited by 31 publications

(34 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the zoonotic potential of C. canimorsus and C. cynodegmi, and the perspective of One Health, it is essential that owners perform oral hygiene for their pets and be aware of the potential for dog or cat bites (or pets licking an owner's wound) to become infected, as a 29.7% mortality rate is reported in severe cases of C. canimorsus infection (Mader et al, 2019). Pet owners are encouraged to seek professional healthcare if they experience symptoms including fever, headache, or mental confusion a few hours to a few days after a pet related injury has occurred, because these are the first clinical signs of infection with C. canimorsus (Taquin et al, 2017;Bialasiewicz et al, 2019;Hundertmark et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

Nogueira

Martini

Menezes

et al. 2021

RSD

View full text Add to dashboard Cite

Capnocytophaga canimorsus e Capnocytophaga cynodegmi são bacilos Gram-negativos encontrados na microbiota oral de cães e gatos capazes de infectar humanos através de mordidas, lambidas ou contato próximo aos animais. As manifestações clínicas vão desde inflamação local da lesão a sepse, podendo ser seguida por óbito em humanos. O objetivo do trabalho foi detectar C. canimorsus e C. cynodegmi em amostras de curetagem subgengival de cães domiciliados atendidos em um Hospital Veterinário Público no Brasil, através da técnica de PCR. De 121 amostras testadas, a prevalência de C. canimorsus foi de 19% e de C. cynodegmi foi de 66,94%. Houve associação significativa entre a presença de C. cynodegmi e doença periodontal avançada. Conclui-se que os microrganismos estão circulantes na microbiota oral de cães domiciliados do Brasil, o que representa um risco à saúde pública devido ao seu potencial zoonótico. Visto a falta de estudos sobre esses microrganismos no país, se faz necessária a realização de pesquisas para compreender a patogenia, manifestações clínicas, diagnóstico e tratamento de infecções por C. canimorsus e C. cynodegmi no Brasil, visando a Saúde Única.

show abstract

Section: Discussionmentioning

confidence: 99%

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

Nogueira

Martini

Menezes

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…The multiple sequence alignments using the 80 amino acid C-terminal segment of M.HinfI (Figure 7 ) reveals conservation among a variety of DNA methyltransferases in the N4/N6-methyltransferase family including the highlighted human pathogens Mycoplasma girerdii ( 31 ), Bartonella bacilliformis ( 32 ), Bartonella tamaie ( 33 ), Capnocytophaga canimorsus ( 34 ), Helicobacter pylori ( 35 ), Brucella abortus ( 36 ) and Haemophilus influenzae ( 37 ), animal pathogens Mycoplasma nasistruthionis ( 38 ), Ureaplasma diversum ( 39 ), Campylobacter sputorum biovar sputorum ( 40 ), Brachyspira catarrhinii ( 41 ), Mycoplasma californicum ( 42 ), Moraxella lincolnii ( 43 ), Mycoplasma falconis ( 44 ) and Moraxella macacae ( 45 ). These organisms highlight the widespread distribution of this protein segment, since it is present in three of the six classes in the Proteobacteria phylum, three other phyla (Spirochaetes, Bacteroidetes and Tenericutes) as well as an archaea.…”

Section: Resultsmentioning

confidence: 99%

Cell cycle regulated DNA methyltransferase: fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif

Konttinen

Carmody

Pathuri

et al. 2020

Nucleic Acids Research

View full text Add to dashboard Cite

DNA adenine methylation by Caulobacter crescentus Cell Cycle Regulated Methyltransferase (CcrM) is an important epigenetic regulator of gene expression. The recent CcrM-DNA cocrystal structure shows the CcrM dimer disrupts four of the five base pairs of the (5′-GANTC-3′) recognition site. We developed a fluorescence-based assay by which Pyrrolo-dC tracks the strand separation event. Placement of Pyrrolo-dC within the DNA recognition site results in a fluorescence increase when CcrM binds. Non-cognate sequences display little to no fluorescence changes, showing that strand separation is a specificity determinant. Conserved residues in the C-terminal segment interact with the phospho-sugar backbone of the non-target strand. Replacement of these residues with alanine results in decreased methylation activity and changes in strand separation. The DNA recognition mechanism appears to occur with the Type II M.HinfI DNA methyltransferase and an ortholog of CcrM, BabI, but not with DNA methyltransferases that lack the conserved C-terminal segment. The C-terminal segment is found broadly in N4/N6-adenine DNA methyltransferases, some of which are human pathogens, across three Proteobacteria classes, three other phyla and in Thermoplasma acidophilum, an Archaea. This Pyrrolo-dC strand separation assay should be useful for the study of other enzymes which likely rely on a strand separation mechanism.

show abstract

“…According to the literature, mortality from C. canimorsus ranged from 10% to 30% [ 5 , 6 , 11 , 20 ]. Our study found that 6-month all-cause mortality was higher in the human-oral–associated Capnocytophaga group.…”

Section: Discussionmentioning

confidence: 99%

The Characteristics of Capnocytophaga Infection: 10 Years of Experience

Chesdachai

Tai

Yetmar

et al. 2021

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Background Capnocytophaga is a Gram-negative, facultative anaerobe. Human infection is rare but can lead to devastating outcomes. C. canimorsus can cause sepsis following an animal bite, whereas human-oral associated Capnocytophaga infections were reported in immunocompromised patients. Current data on these infections is not robust. Our goal is to provide a contemporary description of a unique characteristic of Capnocytophaga infections. Methods We performed a retrospective review of all patients with Capnocytophaga infection from January 2010 to August 2020 at three main hospitals of Mayo Clinic in Rochester, Minnesota, Scottsdale, Arizona, and Florida. We collected baseline demographic data, clinical characteristics, microbiological data, and outcomes of C. canimorsus and human-oral associated Capnocytophaga infection. Results Among 82 patients with Capnocytophaga infection, 46 patients (56.0%) had bacteremia. The most common species identified in this group was C. sputigena (57.9%), followed by C. canimorsus (34.8%). Patients with human-oral associated Capnocytophaga bacteremia were often immunocompromised, presented with neutropenic fever, and had worse six months all-cause mortality compared to C. canimorsus bacteremia (36.4% vs. 6.2%, p=.03). They also had a higher beta-lactamase production rate (36.4% vs. 0.0%, p=.02). Among patients without bacteremia, the main clinical syndrome was polymicrobial head and neck infections (47.2%). Conclusions Human-oral associated Capnocytophaga bacteremia occurs primarily in immunocompromised patients, particularly those with hematologic malignancy. In contrast, C. canimorsus bacteremia is more likely to present with community-onset infection related to zoonotic exposure. Human-oral associated Capnocytophaga infection without bacteremia is frequently isolated in polymicrobial infection; this phenomenon's significance is yet to be fully understood.

show abstract

Capnocytophaga canimorsus– a potent pathogen in immunocompetent humans – systematic review and retrospective observational study of case reports

Cited by 31 publications

References 114 publications

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

Cell cycle regulated DNA methyltransferase: fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif

The Characteristics of Capnocytophaga Infection: 10 Years of Experience

Contact Info

Product

Resources

About