Capsosiphon fulvescens extracts improve obesity‐associated metabolic disorders and hepatic steatosis in high‐fat diet‐induced obese mice

Abstract

Herbal dietary supplements have attracted more and more attention owing to their relative effectiveness in obesity -related metabolic disorders and diseases. This study investigated the therapeutic effects and underlying mechanisms of Capsosiphon fulvescens (CF) extracts on obesity, their associated metabolic disorders and hepatic steatosis in high-fat diet (HFD)-induced obese mice. Male C57BL/6 mice were fed with normal, HFD/Vehicle and HFD/CF (orally 300 mg/kg/day for CF). After 12 weeks, CF blocked HFD-induced body weight, food intake, liver weight, hepatic triglyceride (TG), fat mass (weight of abdominal subcutaneous fat and epididymal adipose tissue) and biochemical parameters (total cohlesterol, glucose, TG, creatinine, high-density lipoproteins cholesterol and low-density lipoprotein cholesterol) of serum. CF also had improved serum levels of adiponectin, leptin and insulin-like growth factor-1 in HFD/CF mice. Moreover, CF ameliorated the hepatic steatosis-reducing size of white adipose tissue. These results indicate that CF have anti-obesity effects and are effective for reducing metabolic risk and hepatic steatosis.

Photoprotective activities of Capsosiphon fulvescens in UVB‐induced SKH‐1 mice and human keratinocytes

“…The groupings were as follows: (1) noninduced group fed a standard diet (CONT); (2) UVB‐exposed group fed a standard diet (UVB); (3) UVB‐exposed group fed a diet with 0.125% CF; (4) UVB‐exposed group fed a diet with 0.25% CF; (5) UVB‐exposed group fed a diet with 0.5% CF; (6) UVB‐exposed group fed a diet with 1.0% CF; (7) UVB‐exposed group fed a diet with high molecular weight hyaluronic acid (HA‐H); and (8) UVB‐exposed group fed a diet with medium molecular weight hyaluronic acid (HA‐M). Based on the previous study (Yun et al., 2018), a dosage of 300 mg/kg/day corresponds to 0.25% in the mouse feed when considering the body weight of the mice. Since no specific toxicity was observed at this concentration, we used it as a reference and added a lower concentration of 0.125%, as well as higher concentrations of 0.5% and 1%, to conduct the animal experiments at four different dosages.…”