<i>Carum copticum</i>L.: A Herbal Medicine with Various Pharmacological Effects

Boskabady, Mohammad Hossein; Alitaneh, Saeed; Alavinezhad, Azam

doi:10.1155/2014/569087

Cited by 70 publications

(46 citation statements)

References 58 publications

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“…28, 201.97, 194.91 and 38.49 mg/g oil respectively whereas the other nineteen compounds had quantity < 10 mg/g oil. The presence of the three compounds; -terpinene, thymol and P-cymene with high quantity are in good agreement with previous reports on phytochemical investigation of essential oil of this plant 10,14,18,19 . In this study, -pinene had relatively high amount and this was not reported before.…”

Section: Chemical Composition Of Essential Oil and Nhexane Extractsupporting

confidence: 91%

Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds

Abdel‐Hameed¹,

Bazaid²,

Zahrani³

et al. 2014

Orient J Chem

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The aim of this study was to characterize the chemical composition of some volatile components, in vitro antimicrobial and anticancer activity of essential oil and n-hexane extract from Trachyspermum ammi L. (Family Apiaceae). The chemical composition of samples was obtained by GC-MS analysis, the antimicrobial activity was evaluated by disc diffusion method whereas the in vitro anticancer activity was evaluated by sulphorhodamine method. Twenty-three monoterpenoide compounds were identified in the essential oil in which four compounds; -terpinene, thymol, P-cymene and -pinene were the major components of the oil with quantity 266. 28, 201.97, 194.91 and 38.49 mg/g oil respectively whereas the other nineteen compounds had quantity < 10 mg/g oil. Twelve monoterpene compounds were identified in the n-hexane extract in which three compounds. Thymol, -terpinene and P-cymene were the major components of volatile components of the n-hexane extract with quantity 138.85, 56.41 and 32.69 mg/g extract respectively whereas the other nine compounds had quantity < 10 mg/g extract. The essential oil and n-hexane extract exhibited an antimicrobial activity against five microorganisms and an anticancer activity against HepG2. The essential oil showed higher activity than the n-hexane. Thymol, terpinene and P-cymene of the two samples play an important role in antimicrobial and anticancer activity. In conclusion, this considered the first report that gave the real quantity of each volatile compound in the essential oil and n-hexane extract of T. ammi. Also, this the first work dealing with the anticancer activity of the two samples in addition to the agreement of antimicrobial activity with previous studies. More safety and toxicological studies will need to be addressed if the essential oil and n-hexane extract of T. ammi are to be used for food preservation or medicinal purposes.

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Section: Chemical Composition Of Essential Oil and Nhexane Extractsupporting

confidence: 91%

Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds

Abdel‐Hameed¹,

Bazaid²,

Zahrani³

et al. 2014

Orient J Chem

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“…The results indicated a potent relaxant effect of carvacrol on the tracheal smooth muscles of guinea pigs (Boskabady and Jandaghi, 2003). Moreover, the relaxant effect of C. copticum was reported in a recent review article (Boskabady et al, 2014).…”

Section: Capparis Spinosamentioning

confidence: 73%

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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“…16) Essential oils containing carvacrol have been widely used in various traditional medicines. 17) Carvacrol possesses anti-inflammatory, antioxidant, and bactericidal properties.…”

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confidence: 99%

Carvacrol Inhibits Osteoclastogenesis and Negatively Regulates the Survival of Mature Osteoclasts

Deepak

Kasonga

Kruger

et al. 2016

Biological & Pharmaceutical Bulletin

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Bone is a dynamic tissue that undergoes continuous remodeling coupled with the action of osteoblasts and osteoclasts. Osteoclast activity is elevated during osteoporosis and periodontitis resulting in excessive loss of trabecular and alveolar bone. Osteoclasts are formed in an inflammatory response to cytokine production receptor activator of nuclear factor-kappaB (NF-κB) ligand (RANKL) and bacterial challenge lipopolysaccharide (LPS). Carvacrol, a monoterpenic phenol present in Origanum vulgare and Thymus vulgaris, is a natural compound with known medicinal properties. We investigated the effects of carvacrol Key words osteoclast; osteoporosis; periodontitis; receptor activator of nuclear factor-κB ligand (RANKL); lipopolysaccharide (LPS) Bone homeostasis is tightly coupled to the bone-forming activity of osteoblasts and bone-resorbing activity of osteoclasts.1) Osteoclasts are multi-nucleated cells that arise from hematopoietic progenitors of monocyte/macrophage lineage and specialize in bone resorption.2) Bone-loss related diseases such as osteoporosis and periodontitis are associated with increased osteoclast formation and elevated osteoclast activity. [3][4][5] Binding of receptor activator of nuclear factor-κB ligand (RANKL) to its receptor RANK in osteoclast precursors triggers trimerization of the receptor and subsequent activation of downstream signaling pathways that includes inhibitor of kappaB (IκB)-a/b kinase (IKK), nuclear factor kappa-B (NF-κB), mitogen-activated protein kinases (MAPKs)-p38, extracellular-signal-regulated kinase (ERK) and c-Jun Nterminal kinase (JNK).6) Activation of these pathways leads to the formation of tartrate resistant acid phosphatase-positive (TRAP+) osteoclasts and bone resorption.Development of apical periodontitis is associated with the presence of microorganisms in the root canal system. 7) Gramnegative bacteria are the most common causative agents in endodontic infections. 8) Bacterial death causes release of lipopolysaccharide (LPS) in the necrotic pulp and dental wall of periapically affected teeth. 9) LPS elicits alveolar bone loss during periodontitis. 10) LPS stimulates the secretion of cytokines by osteoclast precursors such as monocytes and macrophages, resulting in osteoclast formation and bone resorption in vitro and in vivo.11) Earlier studies have also shown that injection of LPS into mouse gingiva induces alveolar bone resorption. 12)

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Carum copticumL.: A Herbal Medicine with Various Pharmacological Effects

Cited by 70 publications

References 58 publications

Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds

Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Carvacrol Inhibits Osteoclastogenesis and Negatively Regulates the Survival of Mature Osteoclasts

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