<i>Cathepsin D</i> gene expression outlines the areas of physiological cell death during embryonic development

Zuzarte‐Luís, Vanessa; Montero, Juan A.; Torre-Pérez, Nuria; García‐Porrero, Juan A.; Hurlé, Juan M.

doi:10.1002/dvdy.21076

Cited by 29 publications

(23 citation statements)

References 33 publications

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“…A number of genes have been implicated in this form of cell death. 9 However, the individual contribution of these genes can be hard to evaluate either because the interdigital tissue is ultimately resorbed or the embryos die before birth. 10,11 In contrast, as shown in Figure 1a, the bax À/À bak À/À mice display the persistence of interdigital webs into adulthood.…”

Section: Development In the Absence Of Bax And Bakmentioning

confidence: 99%

Cell death in the absence of Bax and Bak

Lindsten

Thompson²

2006

Cell Death Differ

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Section: Development In the Absence Of Bax And Bakmentioning

confidence: 99%

Cell death in the absence of Bax and Bak

Lindsten

Thompson²

2006

Cell Death Differ

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“…They also have roles in developmentally programmed cell death [99,100] and in eye physiology and pathology [22,23,101].…”

Section: Proteolysis Dna Degradation and Dna Repair (A) Caspases Andmentioning

confidence: 99%

Lens fibre cell differentiation and organelle loss: many paths lead to clarity

Wride

2011

Phil. Trans. R. Soc. B

180

152

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The programmed removal of organelles from differentiating lens fibre cells contributes towards lens transparency through formation of an organelle-free zone (OFZ). Disruptions in OFZ formation are accompanied by the persistence of organelles in lens fibre cells and can contribute towards cataract. A great deal of work has gone into elucidating the nature of the mechanisms and signalling pathways involved. It is apparent that multiple, parallel and redundant pathways are involved in this process and that these pathways form interacting networks. Furthermore, it is possible that the pathways can functionally compensate for each other, for example in mouse knockout studies. This makes sense given the importance of lens clarity in an evolutionary context. Apoptosis signalling and proteolytic pathways have been implicated in both lens fibre cell differentiation and organelle loss, including the Bcl-2 and inhibitor of apoptosis families, tumour necrosis factors, p53 and its regulators (such as Mdm2) and proteolytic enzymes, including caspases, cathepsins, calpains and the ubiquitinproteasome pathway. Ongoing approaches being used to dissect the molecular pathways involved, such as transgenics, lens-specific gene deletion and zebrafish mutants, are discussed here. Finally, some of the remaining unresolved issues and potential areas for future studies are highlighted.

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“…Programmed cell death is an integral part of animal development and can lead to significant remodeling of appendages. Cell death is responsible for generating interdigital spaces in tetrapod limb buds (83,84) and for creating cavities in the developing inner ear (85). In insects, programmed cell death sculpts head morphology in flies (86) and remodels the outer margins of butterfy wings (87).…”

Section: Changes In the Amount Of Horn Resorption During The Pupal Pementioning

confidence: 99%

On the origin and evolutionary diversification of beetle horns

Emlen

Lavine

Ewen-Campen

2007

Proc. Natl. Acad. Sci. U.S.A.

185

149

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Many scarab beetles produce rigid projections from the body called horns. The exaggerated sizes of these structures and the staggering diversity of their forms have impressed biologists for centuries. Recent comparative studies using DNA sequence-based phylogenies have begun to reconstruct the historical patterns of beetle horn evolution. At the same time, developmental genetic experiments have begun to elucidate how beetle horns grow and how horn growth is modulated in response to environmental variables, such as nutrition. We bring together these two perspectives to show that they converge on very similar conclusions regarding beetle evolution. Horns do not appear to be difficult structures to gain or lose, and they can diverge both dramatically and rapidly in form. Although much of this work is still preliminary, we use available information to propose a conceptual developmental model for the major trajectories of beetle horn evolution. We illustrate putative mechanisms underlying the evolutionary origin of horns and the evolution of horn location, shape, allometry, and dimorphism.allometry ͉ development ͉ phenotypic plasticity ͉ sexual selection ͉ weapons

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Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development

Cited by 29 publications

References 33 publications

Cell death in the absence of Bax and Bak

Cell death in the absence of Bax and Bak

Lens fibre cell differentiation and organelle loss: many paths lead to clarity

On the origin and evolutionary diversification of beetle horns

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