<i>Chlamydia abortus</i> in Pregnant Woman with Acute Respiratory Distress Syndrome

Pichon, Nicolas; Guindre, Laure; Laroucau, Karine; Cantaloube, Muriel; Nallatamby, Agathe; Parreau, Simon

doi:10.3201/eid2603.191417

Cited by 43 publications

(34 citation statements)

References 9 publications

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“…Consequently, the lack of adequate sanitary guidelines can facilitate the progress of the disease and negatively impact sheep farming. In addition, C. abortus presents risks to human health, especially to workers who are unaware of the disease and to pregnant women who deal with animals [14].…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors Associated with Seroprevalence of Chlamydia abortus in Sheep Farms in Ceará, Brazil

Lima

Alves

Pinheiro

et al. 2021

Acta Scientiae. Vet.

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Background: Chlamydia abortus infections (Chlamydiosis) can cause reproductive problems in sheep, such as abortions and birth defects, leading to farm productivity loss. The symptoms, which are similar to other reproductive diseases, and the microbial pathogenesis make the clinical diagnosis difficult. Chlamydia abortus is a zoonotic pathogen, making it a public health issue because it can infect and induce abortions in humans. This study investigated anti-C. abortus antibody levels and infection risk factors in sheep in the State of Ceará, Brazil.Materials, Methods & Results: Forty-three properties from 10 municipalities in 4 mesoregions in the State of Ceará, Brazil (Sertões, metropolitan Fortaleza, North Ceará and Northwest Ceará) with sheep, goats, cattle, and horses were visited. Five hundred and four serological samples from sheep were collected and tested for anti-C. abortus antibodies using an Enzyme-linked Immunosorbent Assay (ELISA) [IDEXX®, Australia] and all procedures were performed in accordance with the manufacturer's instructions at the Clinical Pathology Laboratory of EMBRAPA Goats and Sheep (Sobral, Brazil). Individual questionnaires were completed about sheep breeding practices and to identify possible C. abortus risks. Seropositive results were found in 18.45 % (93/504 individuals) of sheep, and 88.37 % (38/43 properties) of the herds had at least one seropositive animal. The number of seropositive individuals was significantly different between adults and ewes [P < 0.01; Odds Ratio (OR) = 0.510; 95% confidence interval (CI) = 0.306 - 0.850]. Logistic regression modeling identified a missing health certificate request for newly acquired animals as a chlamydiosis risk factor [P = 0.038; OR = 2.672; 95% CI = 1.058 - 6.749].Discussion: The prevalence of anti-C. abortus antibodies in sheep in the State of Ceara emphasizes the importance of testing and tracking the disease spread among herds; these results were similar to studies in other areas of Brazil. Adult sheep that spend more time on the property may have a higher exposure risk because of increased reproductive activity. Misinformation and technical limitations can influence the proper handling of animals avoiding contagion through the correct use of techniques and recommendations. Disease transmission occurs through the digestive tract and between mother and fetus. Therefore, seropositive (infected) sheep may be related to the breeding system practices, such as allowing contact between sheep and other species on the property (goats, cattle, and horses) during breeding. Acquiring animals from external sources without sufficient health information can increase the transmission risk. Contaminated pastures, water, food, and air also increase transmission risk. The lack of technical and practical knowledge regarding disease prevention and control also contributes to disease transmission, resulting in reproductive losses due to high abortion rates. Chlamydia abortus has zoonotic potential and may infect humans without proper safety information. Therefore, future epidemiological studies are required for a better understanding of the primary risk factors for disease occurrence and spread among herds in the region. Chlamydia abortus infection is present in sheep in Ceará, Brazil. Chlamydiosis information programs should be adopted, sanitary measures implemented, and the epidemiological surveillance of sheep herds strengthened.

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Section: Discussionmentioning

confidence: 99%

“…It presents a characteristic biphasic development cycle, with two morphologically distinct forms [2]. The zoonotic implications of the bacteria are miscarriage in women and severe generalized infection with fetal loss [3,14].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Seroprevalence of Chlamydia abortus in Sheep Farms in Ceará, Brazil

Lima

Alves

Pinheiro

et al. 2021

Acta Scientiae. Vet.

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“…The Chlamydial organism reaches the placenta, and multiplies in the epithelial cells of the trophoblasts, which damages the placental vitality. The level of C-reactive protein is raised, along with a decrease in platelet count in the infected females (Pichon et al 2020). In non-pregnant females, the infection is associated with the development of "pelvic inflammatory disease" (Walder et al 2003).…”

Section: Zoonosismentioning

confidence: 99%

“…At present, more sensitive and more specific serological ELISA-based test has been developed which uses major outer membrane protein (MOMP) and polymorphic outer membrane protein (POMP). Female 27 23 rd week Headache, cough, fever, in utero fetal death (Pichon et al 2020) France…”

Section: Introductionmentioning

confidence: 99%

Animal and Public Health Significance of Chlamydiosis

2021

Int J Vet Sci

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“…C. abortus is an important pathogen in cattle, capable of causing, premature birth, stillborn or weak offspring [ 8 , 13 ]. It can also cause zoonotic infection, especially in pregnant women, where infection can lead to pelvic inflammatory disease, placental dysfunction and late-term fetal death [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Chlamydia abortus infection in yak (Bos grunniens) in Tibet, China

Liang

Wen

et al. 2021

Ir Vet J

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Chlamydia spp. are prevalent zoonotic pathogens that infect a wide variety of host species. Chlamydia abortus (C. abortus) infection in yaks has been reported in Gansu and Qinghai province, China. However, no data about C. abortus infection are available in yaks in Tibet, China. A total of 938 serum samples was collected from yaks in Tibet, China and specific antibodies against C. abortus were detected by the enzyme-linked immunosorbent assay (ELISA). The results showed that the overall seroprevalence of C. abortus in yaks was 104/938 (11.1 %, 95 % confidence interval [CI] 9.1–13.1). The prevalence in female and male yaks was 59/556 (10.6 %, 95 % CI 8.0-13.2) and 45/382 (11.8 %, 95 % CI 8.5–15.0), respectively with no significant difference (p > 0.05). The seroprevalence of antibodies to C. abortus in yaks ranged from 8.0 to 18.2 % among the six different areas, and the difference was also without statistical significance (p > 0.05). The prevalence among different age groups ranged from 7.0 to 15.9 %, with a higher prevalence among 1 to 2 years age category. The results demonstrate the presence of C. abortus infection in yaks in Tibet and may pose a risk for the general yak populations in addition to its potential impact on public health and the local Tibetan economy. To our knowledge, this is the first seroprevalence survey of C. abortus in yaks in Tibet, China.

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Chlamydia abortus in Pregnant Woman with Acute Respiratory Distress Syndrome

Cited by 43 publications

References 9 publications

Risk Factors Associated with Seroprevalence of Chlamydia abortus in Sheep Farms in Ceará, Brazil

Risk Factors Associated with Seroprevalence of Chlamydia abortus in Sheep Farms in Ceará, Brazil

Animal and Public Health Significance of Chlamydiosis

Seroprevalence of Chlamydia abortus infection in yak (Bos grunniens) in Tibet, China

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