<i>Chlamydia pneumoniae</i> infection and the risk of female early‐onset lung cancer

Anttila, Tarja; Koskela, Pentti; Leinonen, Maija; Laukkanen, Päivi; Hakulinen, Timo; Lehtinen, Matti; Pukkala, Eero; Paavonen, Jorma; Saikku, Pekka

doi:10.1002/ijc.11353

Cited by 38 publications

(40 citation statements)

References 9 publications

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“…1,3,4 To our knowledge, only 1 study has demonstrated an association between chronic infection and lung cancer among women. 2 This study, nested within the Finnish Maternity Cohort, observed a smoking-adjusted 2-fold increase in risk of early-onset lung cancer among women with elevated IgA (Ͼϭ64) or IgG (Ն128) titers. Among nonsmokers, the role of C. pneumoniae infection is largely unexplored.…”

Section: Dear Sirmentioning

confidence: 82%

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Koh

Chow

Phoon

et al. 2004

Intl Journal of Cancer

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Section: Dear Sirmentioning

confidence: 82%

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Koh

Chow

Phoon

et al. 2004

Intl Journal of Cancer

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“…Many clinical epidemiological studies analyzing the association between Cpn infection and the risk of lung cancer have been reported (Jackson et al, 2000;Koyi et al, 2001;Anttila et al, 2003;Kocazeybek, 2003;Littman et al, 2004;Littman et al, 2005;Chaturvedi et al, 2010), but no clear consensus has been reached (Koh et al, 2005;Sessa et al, 2008;Smith et al, 2008). This relationship was assessed more closely by performing a meta-analysis (Zhan et al, 2011) based on publications collected from electronic databases such as Pubmed, Embase, Web of Science, and CNKI.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chu

Guo²,

Pan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Similarly, in two recent prospective studies of the association between C. pneumoniae antibodies and lung cancer, elevated risks were found for squamous cell cancers but not adenocarcinomas of the lung, 26,27 though another study did not find this difference by histologic type. 28 It may be that the underlying pathogenic mechanisms of Chlamydia in cancer are specific to squamous cell cancers.…”

Section: Discussionmentioning

confidence: 99%

Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors

Madeleine

Anttila

Schwartz

et al. 2006

Intl Journal of Cancer

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Human papillomavirus (HPV) is the central etiologic factor for cervical cancer, and prior studies suggested C. trachomatis may act as an HPV cofactor. We examined the C. trachomatis-cervical cancer association by serotype, histology, HPV type in the tumor, and other HPV cofactors. We conducted a population-based study in the Seattle-Puget Sound area of 302 women with invasive squamous cell carcinomas (SCC), 185 women with adenocarcinomas of the cervix (AC), and 318 HPV seropositive control women. The risk of SCC associated with antibodies to C. trachomatis was increased (OR 1.6, 95% CI 1.1-2.2) but not for AC (OR 1.0, 95% CI 0.6-1.5). This association was independent of HPV type in the SCC tumor tissue. There was an association between specific serotypes of C. trachomatis and SCC for 6 of the 10 serotypes: B (OR 3.6, 95% CI 1.5-8.4), D (OR 2.1, 95% CI, 1.2-3.5), E (OR 2.4, 95% CI, 1.4-3.9), G (OR 3.0, 95% CI, 1.1-7.9), I (OR 4.2, 95% CI, 1.5-11.7), and J (OR 2.3, 95% CI, 1.0-5.1), but not for the 4 types (C, F, H, and K) that were present at very low prevalence in this population. There was an increased risk of SCC, but not AC, associated with antibodies to C. trachomatis that was not serotype specific. ' 2006 Wiley-Liss, Inc.Key words: Chlamydia trachomatis; HPV; cervical cancer; histologic type; microimmunofluorescence Certain oncogenic genital human papillomavirus types (HPV) that are sexually transmitted have been shown to be a necessary but not sufficient cause of cervical cancer. 1 These oncogenic HPVs most often result in transient infections of the cervix, and only a small proportion of exposed women eventually progress to cervical cancer. 2 Since few women exposed to sexually transmitted HPV get cervical cancer, we are interested in cofactors in addition to HPV that promote the development of cancer. One such possible cofactor is Chlamydia trachomatis, which is highly prevalent among sexually active young women and can infect the cervix for long periods of time. Risk factors for C. trachomatis infection are similar to those for genital HPV infections, and include a history of multiple sexual partners, a recent new sexual partner, early age at first intercourse, and sporadic use of condoms or other barrier methods of contraception. 3,4 C. trachomatis often causes cervicitis, which is a chronic infection of the endocervical cells of the transformation zone. Such inflammation may predispose women to other STDs, including genital HPV infection, by damaging epithelial integrity. 5 Recent studies suggested that a history of C. trachomatis infection was associated with persistence of oncogenic HPV infections, 6,7 and other studies have shown that persistent HPV infections are necessary for progression to high-grade cervical intraepithelial neoplasia (CIN) and carcinoma. 2,8 Thus, chronic cervical inflammation by C. trachomatis could increase the risk of transformation of cervical cells that are persistently infected with oncogenic types of HPV.C. trachomatis antibodies are not used for clinical assessment of ...

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Chlamydia pneumoniae infection and the risk of female early‐onset lung cancer

Cited by 38 publications

References 9 publications

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors

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