<i>Chlamydia pneumoniae</i>
            Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Required for Major Histocompatibility Complex Antigen Expression

Fan, Peiyi; Dong, Feng; Huang, Yanqing; Zhong, Guangming

doi:10.1128/iai.70.3.1664a-1664a.2002

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2022

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“…Ongoing research demonstrates that baicalin might affect the expression of chlamydial protease-like activity factor (CPAF) in HEP-2 cells with C. trachomatis infection. Baicalin can target and down-regulate CPAF production so that the immune system can detect chlamydial infection more effectively (Fan et al, 2002 ; Hao et al, 2009 ). Furthermore, studies have demonstrated that CPAF degrades host transcription factors, including RFX5, which is necessary for Chlamydia to evade host immune recognition defense mechanisms (Hao et al, 2010 ).…”

Section: Non-antibiotic Approachesmentioning

confidence: 99%

Alternative strategies for Chlamydia treatment: Promising non-antibiotic approaches

et al. 2022

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Chlamydia is an obligate intracellular bacterium where most species are pathogenic and infectious, causing various infectious diseases and complications in humans and animals. Antibiotics are often recommended for the clinical treatment of chlamydial infections. However, extensive research has shown that antibiotics may not be sufficient to eliminate or inhibit infection entirely and have some potential risks, including antibiotic resistance. The impact of chlamydial infection and antibiotic misuse should not be underestimated in public health. This study explores the possibility of new therapeutic techniques, including a review of recent studies on preventing and suppressing chlamydial infection by non-antibiotic compounds.

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Section: Non-antibiotic Approachesmentioning

confidence: 99%