<i>Chlamydia trachomatis</i>IgG seroprevalence in the general population of the Netherlands in 1996 and in 2007: differential changes by gender and age

Aar, Fleur van; Moraes, Marielly de; Morré, Servaas A.; Bergen, Jan E. A. M. van; Klis, Fiona R.M. van der; Land, J. A.; Sande, Marianne A. B. van der; Broek, Ingrid V F van den

doi:10.1136/sextrans-2013-051074

Cited by 23 publications

(28 citation statements)

References 28 publications

(38 reference statements)

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“…In the Netherlands, two such seroprevalence studies were conducted 10 years apart 24. However, there are several difficulties that need to be overcome before seroprevalence surveys can be used for control policy evaluation for STI.…”

Section: Discussionmentioning

confidence: 99%

National prevalence estimates of chlamydia and gonorrhoea in the Netherlands

et al. 2018

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Section: Discussionmentioning

confidence: 99%

National prevalence estimates of chlamydia and gonorrhoea in the Netherlands

et al. 2018

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“…The higher proportion of women who are Pgp3 seropositive also holds true for MOMP peptide serology [ 9 , 21 , 37 ]. The mechanism for this is unclear, and merits further investigation [ 9 , 21 ]. We observed a lower Pgp3 sensitivity, 25%, in men in the Dunedin cohort than the 54.4% observed in Ct detection-positive men attending GUM clinics.…”

Section: Discussionmentioning

confidence: 99%

“…The double-antigen assay performance was compared to our indirect IgG ELISA which takes less operator time and less sample volume (1μl) [ 9 ], and to the Ct-IgG-pELISA plus Medac assay (Medac, Wedel, Germany) [ 3 , 9 , 21 , 22 ], the SeroCT-IgG ELISA (Savyon Diagnostics, Ashdod, Israel) [ 3 , 9 , 22 ], the Ct IgG EIA (Ani Labsystems, Vantaa, Finland) [ 3 , 7 , 9 , 22 , 23 ] and Ct antibody at 1 in 32 titre using the C . pneumonia IgG/IgM MIF test kit (Ani Labsystems, Finland) [ 3 , 9 ].…”

Section: Methodsmentioning

confidence: 99%

Chlamydia trachomatis Pgp3 Antibody Persists and Correlates with Self-Reported Infection and Behavioural Risks in a Blinded Cohort Study

et al. 2016

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Chlamydia trachomatis (Ct) serological studies in populations could help monitor changes in lifetime cumulative risk of infection. We developed a double-antigen sandwich ELISA based on the Ct-specific Pgp3 antigen, then tested blind stored sera from over 800 participants in a New Zealand birth cohort from Dunedin at ages 26, 32 and 38. The double-antigen sandwich ELISA was more sensitive than our previously characterised indirect Pgp3 ELISA. Pgp3 antibody was detected more often in women compared to men and correlated with increasing numbers of sexual partners, self-reported Ct, and younger age at sexual debut in both women and men. At age 26, 24.1% (99/411) of women were Pgp3 seropositive, as were 79.5% (35/44) of those reporting Ct infection; Pgp3 antibody persisted to age 38 in 96.5% (83/86). In men at age 26, the figures were 10.7% (47/442) and 25.0% (6/24), respectively, with high (83.9%) antibody persistence to age 38. At age 38, among those Pgp3 seropositive, 63.3% of women and 83.1% of men had not reported Ct infection. Thus, Ct-specific Pgp3 antibody was detected in most women reporting Ct infection and correlated with risk of infection in those who did not, with most infections remaining undetected. As this antibody persisted for at least twelve years in 96% of these women, serology could be used to evaluate Ct prevention programmes among women.

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“…Therefore, most epidemiologic studies to date have examined Tv infection in relation to PCa by using serology as a marker of cumulative Tv exposure in older men. Although these studies observed good agreement between blinded replicate specimens (89–94% agreement [5, 6, 8]), only two small older studies, to our knowledge, have examined antibody persistence or intra-individual variability over time [9, 10], both of which were composed mainly of women who tend to be more likely to seroconvert or be seropositive for STIs than men [11–14]. Therefore, we examined Tv antibody persistence and intra-individual variability over time in male participants in the Southern Community Cohort Study (SCCS).…”

Section: Introductionmentioning

confidence: 99%

Persistence of Trichomonas vaginalis serostatus in men over time

Sutcliffe¹,

Alderete

Neace

et al. 2015

Cancer Causes Control

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Purpose Previous epidemiologic studies have observed positive associations between Trichomonas vaginalis (Tv) serostatus and both prostate cancer (PCa) risk and mortality. However, only a few small older studies have examined Tv antibody persistence over time, all of which were composed mainly of female patients. Therefore, we examined Tv antibody persistence over time, as well as intra-individual variability, among middle- to older-aged men in the Southern Community Cohort Study (SCCS). Methods We tested baseline and repeat plasma specimens (collected 1–3 years later) from 248 male participants for Tv antibodies. We used the same enzyme-linked immunosorbent assay as in previous studies of Tv serostatus and PCa. Results At baseline, 46 (18.5%) participants were seropositive for Tv infection. Seventy-six percent of these men were still seropositive 1–3 years later. A similar proportion of men “seroconverted” (4.0%) as “seroreverted” (4.4%), all of whom had absorbance values near the cut-off point for seropositivity. Overall, substantial agreement was observed between baseline and repeat serostatus (kappa=0.72, 95% confidence interval: 0.60–0.83). Conclusion Tv seropositivity was largely persistent between plasma specimens collected 1–3 years apart from middle- to older-aged men. These high levels of persistence are similar to those observed for other sexually transmitted infections frequently investigated in relation to PCa.

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Chlamydia trachomatisIgG seroprevalence in the general population of the Netherlands in 1996 and in 2007: differential changes by gender and age

Abstract: Between 1996 and 2007 the proportion of individuals in the general population with CT IgG antibodies was lower among women aged 25-39 years, but remained similar among younger women and men.

Cited by 23 publications

References 28 publications

National prevalence estimates of chlamydia and gonorrhoea in the Netherlands

National prevalence estimates of chlamydia and gonorrhoea in the Netherlands

Chlamydia trachomatis Pgp3 Antibody Persists and Correlates with Self-Reported Infection and Behavioural Risks in a Blinded Cohort Study

Persistence of Trichomonas vaginalis serostatus in men over time

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