<i>Chlamydophila Pneumoniae</i>Respiratory Tract Infection Aggravates Therapy Refractory Bronchitis or Pneumonia in Childhood

Schmidt, S.; Müller, Cornelia; Gürtler, Lutz; Bruns, R; Ballke, E H; Wiersbitzky, H; Ehlers, Monika; Rose, H. J.; Wiersbitzky, S

doi:10.1055/s-2004-818791

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Consequently, impaired defence might facilitate adhesion of further micro-organisms to the bronchial system. In children with C. pneumoniae infection, bacterial co-infections and coinfections with mycoplasmas were identified as factors often associated with purulent bronchial inflammation and restrictive disturbances of lung function leading to more severe disease [42].…”

Section: Clinical Outcome and Pathogenesis Of Chlamydial Infections Wmentioning

confidence: 99%

A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

et al. 2007

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-This study was aimed at evaluating functional and inflammatory consequences of persistent chlamydial infections on the respiratory system in clinically inconspicuous calves aged 2-7 months. Thirteen calves persistently infected with Chlamydophila (C.) abortus and/or C. pecorum (Chl+) were compared to 12 calves without chlamydial infections (Chl-). In order to evaluate lung function, 36 non-invasive impulse oscillometry tests were performed per animal within 6 months. The group of chronically infected animals was distinguished by significantly higher peripheral airway resistance (indicating peripheral airway obstruction), significantly higher respiratory rates, and significantly higher minute volumes of ventilation. At the age of seven months, all calves were necropsied, broncho-alveolar lavage fluid (BALF) was obtained ex vivo, and lungs were examined histologically. Significantly higher concentrations of total protein and 8-iso-prostane (8-IP), as well as higher activities of matrix metalloprotease 2 were measured in BALF samples of Chl+ calves. Histologically, markedly activated bronchus-associated lymphoid tissue (BALT) causing partial obstruction of bronchiolar lumina was found in the apical pulmonary lobes of Chl+ calves. Chlamydial DNA was detected in the lung tissue of 7 out of 13 Chl+ calves by real-time PCR. In conclusion, respiratory chlamydial infection appeared to be associated with chronic inflammation of the lungs and airways. Despite the lack of clinical symptoms, pulmonary dysfunctions persisted in calves until the age of seven months. Data obtained in this study provide new insight illustrating the impact of nearly ubiquitous subclinical infections on the respiratory system. Chlamydia / Chlamydophila infection / airway obstruction / pulmonary inflammation / calves

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Section: Clinical Outcome and Pathogenesis Of Chlamydial Infections Wmentioning

confidence: 99%

A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

et al. 2007

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“… 17 – 20 Of the causative pathogens, both Mycoplasma pneumoniae and Chlamydia pneumoniae are strongly associated with new-onset asthma, recurrent wheezing, refractory bronchitis, acute bronchiolitis, and asthma exacerbations in children. 18 , 21 – 24 It has been reported that C. pneumoniae infection is common in school-age children and the immune response to chronic C. pneumoniae infection may intercommunicate with allergic inflammation to exacerbate asthma symptoms. 15 In patients with asthma with M. pneumoniae infection, the use of macrolides may alleviate the symptoms of asthma.…”

Section: Introductionmentioning

confidence: 99%

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials

Lei

Lin

Tsai

et al. 2018

DDDT

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PurposeChildhood reactive airway diseases (RADs) are concerning problems in children’s airways and may be preceded by bronchiolitis and may progress to childhood asthma. The severity of the disease is indicated by deterioration in pulmonary functions, increased usage of rescue medications, and recurrent wheezing episodes. Macrolides have both antimicrobial and anti-inflammatory functions and have been used as adjunctive therapy in childhood RADs.Patients and methodsWe conducted a meta-analysis to evaluate the effect of macrolides in children with RAD. Literature searches were systematically conducted using an electronic database from inception to August 2018. The Cochrane review risk of bias assessment tool was used to assess the quality of each randomized controlled trial.ResultsSixteen randomized controlled trials comprising 1,415 participants were investigated in this meta-analysis. Children treated with macrolide therapy showed significantly better pulmonary functions in both forced expiratory volume in one second (% predicted) (difference in means=−9.77, 95% CI=−14.18 to −5.35, P<0.001; I2=0%) and forced expiratory flow 25–75 (% predicted) (difference in means=−14.14, 95% CI=−26.11 to −2.18, P=0.02; I2=29.56%). In addition, the short-acting β-agonist usage days and recurrent wheezing risk were significantly lowered in children with macrolide treatment (standardized difference in means=−0.34, 95% CI=−0.59 to −0.09, P=0.007, I2=27.05% and standardized difference in means=−0.53, 95% CI=−0.81 to −0.26, P<0.001, I2=0%, respectively). Furthermore, the growth of Moraxella catarrhalis from nasal swabs was less in children treated with macrolides (odds ratio=0.19, 95% CI=0.11–0.35, P<0.001). Children who took macrolides had a lower risk of adverse events (risk ratio=0.83, 95% CI=0.70–0.98, P=0.024, I2=0%).ConclusionThis current meta-analysis suggested that adjunctive therapy with macrolides is safe and effective for achieving better outcomes in childhood RAD.

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Séquelles respiratoires des infections à Mycoplasma pneumoniae (MP) et Chlamydophyla pneumoniae (CP) chez l’enfant

Labbé

2007

Revue Française d'Allergologie et d'Immunologie Clinique

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Chlamydophila PneumoniaeRespiratory Tract Infection Aggravates Therapy Refractory Bronchitis or Pneumonia in Childhood

Cited by 4 publications

References 22 publications

A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

A clinically silent respiratory infection withChlamydophilaspp. in calves is associated with airway obstruction and pulmonary inflammation

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials

Séquelles respiratoires des infections à Mycoplasma pneumoniae (MP) et Chlamydophyla pneumoniae (CP) chez l’enfant

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