Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy in rats by reduction of blood pressure and inhibition of myocardial hypoxia inducible factor-1alpha expression

Abstract

(2016) Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy in rats by reduction of blood pressure and inhibition of myocardial hypoxia inducible factor-1alpha expression, Pharmaceutical Biology, 54:12, 2895-2900, DOI: 10.1080/13880209.2016 Context: Chrysanthemum morifolium Ramat. (Asteraceae) extract (CME) possesses a vasodilator effect in vitro. However, the use of polyphenol-rich CME in the treatment of hypertension-induced cardiac hypertrophy has not been reported. Objective: We investigated the effect of polyphenol-rich CME on hypertension-induced cardiac hypertrophy in rats and its possible mechanism of action. Materials and methods: The Sprague-Dawley rat model with cardiac hypertrophy was induced by renovascular hypertension. The blood pressure, cardiac weight index, free fatty acids (FFA) in serum and myocardium, and protein expressions of myocardial hypoxia inducible factor-1a (HIF-1a), peroxisome proliferator-activated receptor a (PPARa), carnitine palmitoyltransferase-1a (CPT-1a), pyruvate dehydrogenase kinase-4 (PDK-4) and glucose transporter-4 (GLUT-4) were measured after treating hypertensive rats with polyphenol-rich CME of anthodia 75-150 mg/kg once daily for 4 weeks. A myocardial histological examination was also conducted. Results: After CME treatment, the blood pressure, cardiac weight and cardiac weight index decreased by 5.7-9.6%, 9.2-18.4% and 10.9-20.1%, respectively, and the cardiomyocyte cross-sectional area also decreased by 8.3-30.4%. The CME treatment simultaneously decreased the FFA in serum and myocardium and protein expressions of myocardial HIF-1a and GLUT-4, and increased the protein expressions of myocardial PPARa, CPT-1a and PDK-4, especially in the CME 150 mg/kg group (p < 0.05 or p < 0.01). Discussion and conclusion: Polyphenol-rich CME may alleviate hypertensive cardiac hypertrophy in rats. Its mechanisms may be related to the reduction of blood pressure and amelioration of the myocardial energy metabolism. The latter may be attributed to the inhibition of HIF-1a expression and subsequent modulation of PPARa-mediated CPT-1a, PDK-4 and GLUT-4 expressions. ARTICLE HISTORY

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases

“…Hemsl. exhibited a vasodilatory effect by reducing the blood pressure of cardiac hypertrophy rats (Gao et al, 2016). The major phytochemicals in this extract are 4,5-di-caffeoylquinic acid, 3,5dicaffeoylquinic acid, luteolin-7-b-glucoside, 3-chlorogenic acid (11), and apigenin-7-O-glucoside.…”

“…Extract (Gao et al, 2016) Crassocephalum crepidioides (Benth.) S. Moore Extract (Goldansaz et al, 2018) Inula racemosa Hook F. India, Asian Pushkarmool Hypotensive, antihyperlipidemic and antioxidant…”

UV RESISTANCE LOCUS 8 From Chrysanthemum morifolium Ramat (CmUVR8) Plays Important Roles in UV-B Signal Transduction and UV-B-Induced Accumulation of Flavonoids

“…The flower of C. morifolium has long been used as traditional Chinese medicine and beverage ( Ye et al, 2007 ). Modern pharmacological studies have demonstrated that C. morifolium possesses extensive bioactivities and has functions of anti-inflammation ( Cheon et al, 2009 ; Lee et al, 2009 ; Luyen et al, 2015 ), antioxidation ( Lin et al, 2010 ; Yang, 2011 ), anticancer ( Yuan et al, 2009 ; Wang et al, 2010 ; Yang et al, 2011 ; Kim et al, 2013 ), cardiovascular protection ( Jiang et al, 2005 ), and hepatoprotective ( Rusu et al, 2005 ; Gao et al, 2016 ). Component analysis of C. morifolium showed that flavonoids are the main bioactive compounds, such as luteolin-7- O -glucoside, quercetin-7- O -galactoside, apigenin-7- O -glucoside, diosmetin-7- O -glucoside, and acacetin-7- O -galactoside ( Lin and Harnly, 2010 ; Sun et al, 2010 ).…”

Plasma Lipidomics Reveals Insights into Anti-Obesity Effect of Chrysanthemum morifolium Ramat Leaves and Its Constituent Luteolin in High-Fat Diet-Induced Dyslipidemic Mice

“…The main bioactive components in the flowers of CM are flavonoids and phenolic acids, which are composed of chlorogenic acid, acacetin, apigenin, and luteolin, along with its glucoside form [ 7 ]. Previous studies have shown that CM and its components possess various biological functions, including antioxidant [ 8 ], anti-inflammatory [ 9 ], anti-tumorigenic [ 10 ], and cardiovascular-protective functions [ 11 ]. Moreover, the CM flower extract has been shown to prevent hyperlipidemic fatty liver disease by increasing hepatic peroxisome proliferator-activated receptor (PPAR)-α expression in hyperlipidemic fatty liver disease caused by high-fat milk [ 12 ].…”