<i>circDiaph3</i>
            regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

Xu, Jia‐Ying; Chang, Neng-Bin; Rong, Zhihua; Li, Tao; Xiao, Ling; Yao, Qing; Jiang, Rui; Jiang, Jun

doi:10.1096/fj.201800243rrr

Cited by 39 publications

(23 citation statements)

References 32 publications

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“…For instance, a novel identified circRNA, circRNA_010567, regulates the fibrosis-associated protein resection in myocardial fibrosis diabetic db/db mice, demonstrating the circRNA_010567/miR-141/transforming growth factor β (TGF-β)1 axis in the diabetic mouse myocardial fibrosis model 21 . For other samples, references find that circDiaph3 knockdown increases the level of diaphanous-related formin-3 and promoted the differentiation of VSMCs to contractile type, and circDiaph3 promotes the Igf1r transcription and the proliferation and migration of VSMCs 22 …”

Section: Discussionmentioning

confidence: 99%

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

Yang

Zhao

et al. 2019

Molecular Therapy - Nucleic Acids

118

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Circular RNA (circRNA) is a novel subgroup of noncoding RNA in the human transcriptome playing a vital role in the atherosclerosis of cerebrovascular disease. However, the in-depth mechanism by which circRNA regulates the vascular smooth muscle proliferation and migration is still elusive. Here, a novel identified circRNA, circCHFR, was validated to be aberrantly overexpressed in the ox-LDL-induced vascular smooth muscle cell (VSMCs). Functionally, the circCHFR silencing by oligonucleotide transfection suppressed the proliferation and migration ability of VSMCs. Mechanically, bioinformatics tools and luciferase reporter assay state that circCHFR acts as a sponge of miR-370, and miR-370 targets the 3′ UTR of FOXO1. Furthermore, the transcription factor FOXO1 could bind with the promoter region of CCND1 mRNA and promote Cyclin D1 expression. In summary, this finding states the vital role of the circCHFR/miR-370/FOXO1/Cyclin D1 axis and provides a profound understanding about the circRNA in smooth muscle cells and atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

Yang

Zhao

et al. 2019

Molecular Therapy - Nucleic Acids

118

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“…A series of studies from our group or other researchers has demonstrated that noncoding RNAs, including miRNAs (37)(38)(39)(40) and long noncoding RNAs (41,42) play vital roles in modulating the SC phenotype involved in peripheral nerve regeneration after injury. Emerging evidence has indicated impressive functions of circRNAs in both physiologic and pathologic conditions (43,44), especially in the nervous system and cancers (45,46). However, the role of circRNAs in peripheral nerve regeneration regulatory circRNAs involved in SC proliferation, which is of great importance to peripheral nerve regeneration, we screened differentially expressed circRNAs during sciatic nerve injury repair and focused on the role of a significantly down-regulated circRNAs circ-Ankib1 post-sciatic nerve injury and the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

A Schwann cell–enriched circular RNA circ‐Ankib1 regulates Schwann cell proliferation following peripheral nerve injury

Mao¹,

Zhang²,

Zhou³

et al. 2019

The FASEB Journal

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Schwann cells (SCs) play an essential role in nerve injury repair. A striking feature of the cellular response to peripheral nerve injury is the proliferation of SCs. Circular (circ)RNAs are enriched in the nervous system and are involved in physiologic and pathologic processes. However, the potential role of circRNAs in SC proliferation post nerve injury remains largely unknown. Using a sciatic nerve crush model, we obtained an expression profiling of circRNAs in injured sciatic nerves in rats by RNA sequencing and bioinformatics analysis, and we further identified a circRNA [circ–ankyrin repeat and in‐between Ring finger (IBR) domain containing 1 (Ankib1)] involved in SC proliferation by the transfection of specific small interfering RNAs. Overexpression of circ‐Ankib1, which was specifically and highly enriched in SCs, impaired SC proliferation and axon regeneration following sciatic nerve injury. Mechanistically, increased expression of DEx/H‐box helicase 9 (DHX9) postinjury might contribute to the down‐regulation of circ‐Ankib1, which further suppressed cytochrome P450, family 26, subfamily B, polypeptide 1 expression by sponging miR‐423‐5p, miR‐485‐5p, and miR‐666‐3p, leading to the induction of SC proliferation and nerve regeneration. Taken together, our results reveal a crucial role for circRNAs in regulating proliferation of SCs involved in sciatic nerve regeneration; as such, circRNAs may serve as a potential therapeutic avenue for nerve injury repair.—Mao, S., Zhang, S., Zhou, S., Huang, T., Feng, W., Gu, X., Yu, B. A Schwann cell‐enriched circular RNA circ‐Ankib1 regulates Schwann cell proliferation following peripheral nerve injury. FASEB J. 33, 12409–12424 (2019). http://www.fasebj.org

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“…Recently, there were several researches on the effect of circRNAs on the proliferation, differentiation, and migration of myoblast. For example, in rat, rno-circ_005717 (circDiaph3) promoted vascular smooth muscle cells (VSMCs) differentiation by up-regulated diaphanous-related formin-3 (DIAPH3) and supported its proliferation and migration by up-regulated insulin, such as the growth factor 1 receptor ( IGF1R ) [17]. In mouse myoblast cell line-C2C12, circZfp609 (circular RNA, derived from Zinc Finger Protein 609) could repress the myogenic differentiation by sponge miR-194-5p to sequester its inhibition on the apoptosis regulator (BCL2) associated with transcription factor 1 ( BCLAF1 ) [18].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Differentially Expressed mRNA, lncRNA and circRNA and Their ceRNA Networks in the Longissimus Dorsi Muscle of Two Different Pig Breeds

Wang

Ren

Hua

et al. 2019

IJMS

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Circular RNA (circRNA) and long non-coding RNA (lncRNA) are known to participate in adipogenesis and myogenic differentiation, but their impact on porcine muscle traits is not well understood. We compared their expressional profiles in the longissimus dorsi muscle of Chinese Huainan pigs (HN, the fat type) and Western commercial Duroc×(Landrace×Yorkshire) (DLY, the thin type) pigs, and 854 mRNAs, 233 lncRNAs, and 66 circRNAs (p < 0.05 and ｜log2FoldChange｜>1) were found to be differentially expressed. The differentially expressed mRNA and circRNA parental genes were enriched in the Wnt signaling pathway (adipogenesis), the transition between fast and slow fibers (myogenic differentiation), and alanine, aspartate and glutamate metabolism (pork flavor). The potential lncRNAs/circRNAs-miRNAs-mRNAs regulatory networks shared MYOD1, PPARD, miR-423-5p and miR-874, which were associated with skeletal muscle muscular proliferation, differentiation/regeneration and adipogenesis. Taken together, these differentially expressed non-coding RNAs may be involved in the molecular basis of muscle traits, acting as the competing endogenous RNA (ceRNA) for miRNAs.

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circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

Cited by 39 publications

References 32 publications

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

A Schwann cell–enriched circular RNA circ‐Ankib1 regulates Schwann cell proliferation following peripheral nerve injury

Comprehensive Analysis of Differentially Expressed mRNA, lncRNA and circRNA and Their ceRNA Networks in the Longissimus Dorsi Muscle of Two Different Pig Breeds

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