<i>Circulation: Cardiovascular Interventions</i>

Faxon, David P.; Leopold, Jane A.; Abbott, J. Dawn; McElhinney, Doff B.; Williams, David O.

doi:10.1161/circinterventions.118.006901

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…For many patients with obstructive coronary artery disease, percutaneous coronary intervention (PCI) remains the major revascularization strategy of choice, with an estimated 5 million procedures performed worldwide each year [ 146 ]. A substantial number of chronic coronary syndrome (CCS) patients undergoing elective PCI experience procedural-related myocardial injury and infarction, the occurrences of which are associated with an increased risk of future major adverse cardiovascular events (MACE) such as death, re-infarction, and revascularization [ 147 , 148 ].…”

Section: Cardioprotection – Attenuation Of Myocardial Ischemia/reperf...mentioning

confidence: 99%

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Heusch,

Andreadou,

Bell

et al. 2023

Redox Biology

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Section: Cardioprotection – Attenuation Of Myocardial Ischemia/reperf...mentioning

confidence: 99%

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Heusch,

Andreadou,

Bell

et al. 2023

Redox Biology

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“…Percutaneous coronary intervention (PCI) remains the major revascularization strategy for patients with obstructive coronary artery disease (CAD), with an estimated 5 million procedures performed worldwide each year. 1 In a substantial number of PCI cases for acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), 2 periprocedural myocardial injury or myocardial infarction (MI) occurs, 3 the actual incidences of which depend on the cardiac biomarker measured and the definitions used. Both these PCI-related complications may be associated with an increased risk of future major adverse cardiovascular events (such as death, re-infarction, and revascularization).…”

Section: Introductionmentioning

confidence: 99%

Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Bulluck

Paradies

Barbato

et al. 2021

European Heart Journal

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A substantial number of chronic coronary syndrome (CCS) patients undergoing percutaneous coronary intervention (PCI) experience periprocedural myocardial injury or infarction. Accurate diagnosis of these PCI-related complications is required to guide further management given that their occurrence may be associated with increased risk of major adverse cardiac events (MACE). Due to lack of scientific data, the cut-off thresholds of post-PCI cardiac troponin (cTn) elevation used for defining periprocedural myocardial injury and infarction, have been selected based on expert consensus opinions, and their prognostic relevance remains unclear. In this Consensus Document from the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI), we recommend, whenever possible, the measurement of baseline (pre-PCI) cTn and post-PCI cTn values in all CCS patients undergoing PCI. We confirm the prognostic relevance of the post-PCI cTn elevation >5× 99th percentile URL threshold used to define type 4a myocardial infarction (MI). In the absence of periprocedural angiographic flow-limiting complications or electrocardiogram (ECG) and imaging evidence of new myocardial ischaemia, we propose the same post-PCI cTn cut-off threshold (>5× 99th percentile URL) be used to define prognostically relevant ‘major’ periprocedural myocardial injury. As both type 4a MI and major periprocedural myocardial injury are strong independent predictors of all-cause mortality at 1 year post-PCI, they may be used as quality metrics and surrogate endpoints for clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.

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“…Coronary artery disease (CAD) is a major cause of death and disability among both women and men globally (1,2). Coronary angiography (CAG) is the reference standard for CAD diagnosis and percutaneous coronary intervention (PCI) remain the major revascularization strategy for patients with CAD, with an estimated five million procedures performed worldwide each year (3)(4)(5)(6)(7). Previous studies reported women undergoing PCI were older, suffered from more comorbidities, and had fewer chance to undergo PCI or other bypass treatments compared with men (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Characteristics, Treatments, and In-hospital Outcomes of Patients Undergoing Coronary Angiography or Intervention

Chen

Liu

Zhou

et al. 2022

Front. Cardiovasc. Med.

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BackgroundWhether women have a higher risk of adverse events compared with men following coronary angiography (CAG) and percutaneous coronary intervention (PCI) remains controversial. We aimed to investigate the sex differences in characteristics, treatments and outcomes among patients undergoing CAG and PCI in a large Chinese cohort.MethodsWe analyzed patients undergoing CAG and/or PCI in this multi-center registry cohort study Cardiorenal ImprovemeNt II (CIN-II) in 5 Chinese tertiary hospitals from 2007 to 2020. Clinical characteristics, treatment (discharge medication and PCI) and in-hospital outcomes (mortality and major bleeding) were compared between women and men.ResultsTotally 141,459 patients underwent CAG (44,362 [31.4%] women), of which 69,345 patients underwent PCI (15,376 [22.2%] women). Women were older (64.4 vs. 60.8 years), had more chronic comorbidities and lower PCI rate for stable coronary artery disease (CAD) than men (52.8 vs. 64.2%). Women received less CAG and PCI procedures. Among women undergoing PCI they received similar discharge medication treatment. In addition, women undergoing PCI had mildly lower rate of major bleeding (0.2 vs. 0.3%, P = 0.033) but higher in-hospital mortality (1.2 vs. 0.8%, P < 0.001). After adjustment, women had a higher risk in the major bleeding (adjusted odds ratio, 2.04 [95% CI: 1.07 to 3.62]), and the in-hospital mortality (adjusted odds ratio, 1.87 [95% CI: 1.36 to 2.56]).ConclusionAmong our Chinese cohort, women are older with more chronic comorbidities, receiving less PCI procedure and similar discharge medication treatment. Women have nearly 90% higher risk of in-hospital mortality and over 1-fold increased risk of major bleeding after PCI compared with men.

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Circulation: Cardiovascular Interventions

Cited by 11 publications

References 9 publications

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Sex Differences in Characteristics, Treatments, and In-hospital Outcomes of Patients Undergoing Coronary Angiography or Intervention

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