Clostridioides difficileutilizes siderophores as an iron source and FhuDBGC contributes to ferrichrome uptake
Jessica L. Hastie,
Hannah L. Carmichael,
Bailey M. Werner
et al.
Abstract:Clostridioides difficileremains a public health threat commonly observed following antibiotic use. Due to the importance of iron in many cell processes, most bacteria, includingC. difficile, have multiple mechanisms of acquiring iron. Previous studies have examined ferrous iron uptake inC. difficile, here we focus on the role of siderophores. In a growth assay, we show thatC. difficilecan use a variety of siderophores as the sole iron source. InC. difficile,two ABC transporters induced under low iron condition… Show more
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