<i>Clostridium perfringens</i> splenic abscess treated with percutaneous drainage and antibiotic therapy: a case report

Hellinckx, Hanne; Mertes, Helena; Vanreusel, Inne; Demedts, Ingrid; Dutré, Joris

doi:10.1080/17843286.2021.1940606

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The symptoms of gas gangrene are often severe and require a prompt decision for splenectomy. However, the case of a 74-year-old woman on immunosuppressants reported by Hellinckx et al has improved with percutaneous drainage and antimicrobial therapy [ 12 ]. Therefore, drainage may be a treatment option if the patient's condition permits it.…”

Section: Discussionmentioning

confidence: 99%

“…Although they reported two cases of C. perfringens in their bacterial profile, there was no detailed case report. We searched PubMed from 1946 to 2023 using the keywords "Clostridium perfringens" and "spleen" and found only seven cases of splenic abscess because of C. perfringens [7][8][9][10][11][12][13] Most cases of splenic gas gangrene had underlying disease and were infected with C. perfringens alone. Only the case reported by Gangahar et al had a history of trauma [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gas Gangrene of the Spleen Caused by Clostridium perfringens After Mild Blunt Trauma

Takeuchi,

Taki,

Furuya

et al. 2024

Cureus

View full text Add to dashboard Cite

Splenic gas gangrene caused by Clostridium perfringens is rare. A 73-year-old woman was referred to our hospital because of fatigue, dyspnea, and left hypochondrial pain. She had a history of blunt trauma to the left abdomen eight days ago. She presented with hypoxemia and a high inflammatory response on blood tests. A CT showed left pleural effusion and gas in the spleen. She was treated with antimicrobials and underwent splenectomy. C. perfringens was identified from blood and intraoperative ascites cultures. She recovered and was discharged on day 34 of hospitalization. As C. perfringens is part of the normal gut microbiota and can translocate to other parts of the body, this bacterium should be considered a splenic abscess pathogen when an intracorporeal anaerobic environment is suspected.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gas Gangrene of the Spleen Caused by Clostridium perfringens After Mild Blunt Trauma

Takeuchi,

Taki,

Furuya

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

Adalimumab

2022

Reactions Weekly

View full text Add to dashboard Cite

Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection

Wang,

Meng,

Zhang

et al. 2024

Microbiol Spectr

View full text Add to dashboard Cite

The gut microbiota, a pivotal component of the intestinal mucosal barrier, is critical for host resistance to enteric pathogen infection. Here, we report a novel function of the potentially probiotic Lactococcus garvieae strain LG1 ( L. garvieae strain LG1) in maintaining intestinal mucosal barrier integrity and protecting against foodborne Clostridium perfringens ( C. perfringens ) infection. L. garvieae was isolated from the intestinal contents of Chinese Mongolian sheep (MS) and exhibited potential probiotic properties. In a C. perfringens enterocolitis model, L. garvieae- pretreated mice were less susceptible to C. perfringens infection compared with Phosphate buffered solution (PBS) - pretreated mice, which manifested as higher survival rates, lower pathogen loads, less weight loss, mild clinical symptoms and intestinal damage, and minor inflammation. Further mechanistic analysis showed that L. garvieae could ameliorate the disruption of intestinal permeability and maintain the integrity of the intestinal mucosal barrier by promoting the expression of tight junction proteins and mucoproteins. Moreover, L. garvieae was also able to facilitate antimicrobial peptide expression and ameliorate dysbiosis of the gut microbiota caused by C. perfringens . Together, these findings highlight the prospect of immunomodulatory potentially probiotic L. garvieae and might offer valuable strategies for prophylaxis and/or treatment of pathogenic C. perfringens mucosal infection. IMPORTANCE C. perfringens necrotic enteritis leads to losses of about US $2 billion to the poultry industry worldwide every year. Worse, US Centers for Disease Control and Prevention (CDC) has estimated that C. perfringens causes nearly 1 million foodborne illnesses in the United States annually. Nowadays, the treatment recommendation is a combination of a broad-spectrum synergistic penicillin with clindamycin or a carbapenem, despite growing scientific concern over antibiotic resistance. The global understanding of the gut microbiome for C. perfringens infection may provide important insights into the intervention. L. garvieae originated from Mongolian sheep intestine, exhibited potentially probiotic properties, and was able to limit C. perfringens enterocolitis and pathogenic colonization. Importantly, we found that L. garvieae limits C. perfringens invasion via improving intestinal mucosal barrier function. Also, L. garvieae alleviates C. perfringens -induced gut microbiota dysbiosis. It allowed us to convince that utilization of probiotics to promote protective immunity against pathogens infection is of pivotal importance.

show abstract

Clostridium perfringens splenic abscess treated with percutaneous drainage and antibiotic therapy: a case report

Cited by 3 publications

References 11 publications

Gas Gangrene of the Spleen Caused by Clostridium perfringens After Mild Blunt Trauma

Gas Gangrene of the Spleen Caused by Clostridium perfringens After Mild Blunt Trauma

Adalimumab

Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection

Contact Info

Product

Resources

About