<i>Clusterin</i>, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis

Shapiro, Beny; Tocci, Piera; Haase, Gal; Gavert, Nancy; Ben-Ze’ev, Avri

doi:10.18632/oncotarget.5360

Cited by 44 publications

(40 citation statements)

References 47 publications

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“…In this study, HBE cells were treated with 5-FU, resulting in a decrease in numbers of cells in the S phase and thus, cells in G0/G1 phase were concentrated. This phenomenon has been previously observed in several tumor cells from the gastrointestinal tract [ 25 , 26 ], lung [ 27 – 34 ], and liver [ 35 ]. Treatment of HBE cells with 5-FU resulted in decrease in methylation of Sox2 DNA promoter from 8.4% to 4.8%, and the methylation island disappeared.…”

Section: Discussionsupporting

confidence: 67%

Dormancy activation mechanism of tracheal stem cells

Jia

et al. 2016

Oncotarget

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Accurate markers and molecular mechanisms of stem cell dormancy and activation are poorly understood. In this study, the anti-cancer drug, 5-fluorouracil, was used to selectively kill proliferating cells of human bronchial epithelial (HBE) cell line. This method can enrich and purify stem cell population. The dormant versus active status of stem cells was determined by phosphorylation of RNAp II Ser2. The surviving stem cells were cultured to form stem cell spheres expressing stem cell markers and transplanted into nude mice to form a teratoma. The results demonstrated the properties of stem cells and potential for multi-directional differentiation. Bisulfite sequencing polymerase chain reaction showed that demethylation of the Sox2 promoter by 5-FU resulted in Sox2 expression in the dormant stem cells. This study shows that the dormancy and activation of HBE stem cells is closely related to epigenetic modification.

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Section: Discussionsupporting

confidence: 67%

Dormancy activation mechanism of tracheal stem cells

Jia

et al. 2016

Oncotarget

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“…APOJ promoted metastasis of colon cancer and promoted invasion of tumor via the p38/MAPK/MMP9 pathway . APOJ also conferred resistance of breast cancer cells to TNF α and caused apoptosis via activation of NF‐ κ B and overexpression of Bcl‐2 …”

Section: Apolipoproteins and Cancermentioning

confidence: 99%

Apolipoproteins and cancer

et al. 2019

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The role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress, and drug resistance. The potential application of apolipoproteins as biomarkers for cancer diagnosis and prognosis was highlighted, together with an investigation of their potential as drug targets for cancer treatment. Many important roles of apolipoproteins and their mechanisms in cancers were reviewed in detail and future perspectives of apolipoprotein research were discussed.

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“…The β-catenin-TCF complex was shown to regulate the energy metabolism in CRC stem cells and to fuel the growth of CRC tumors by inducing the expression of the transcription factor PROX1 78 , 79 . The cell adhesion receptor L1 (see above) induces the expression of the ISC marker Clusterin in CRC cells via STAT1 activation that is known to be stimulated by pro-inflammatory cytokines 80 . The increased expression of the ISC marker Msi1 81 , an RNA-binding protein and a β-catenin-TCF target gene, was linked to the elevated metastatic potential and poorer prognosis of CRC 82 , 83 .…”

Section: Crosstalk Between Wnt Signaling and Other Pathways In “Stemnmentioning

confidence: 99%

Wnt signaling in cancer stem cells and colon cancer metastasis

2016

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Overactivation of Wnt signaling is a hallmark of colorectal cancer (CRC). The Wnt pathway is a key regulator of both the early and the later, more invasive, stages of CRC development. In the normal intestine and colon, Wnt signaling controls the homeostasis of intestinal stem cells (ISCs) that fuel, via proliferation, upward movement of progeny cells from the crypt bottom toward the villus and differentiation into all cell types that constitute the intestine. Studies in recent years suggested that cancer stem cells (CSCs), similar to ISCs of the crypts, consist of a small subpopulation of the tumor and are responsible for the initiation and progression of the disease. Although various ISC signature genes were also identified as CRC markers and some of these genes were even demonstrated to have a direct functional role in CRC development, the origin of CSCs and their contribution to cancer progression is still debated. Here, we describe studies supporting a relationship between Wnt-regulated CSCs and the progression of CRC.

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Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis

Cited by 44 publications

References 47 publications

Dormancy activation mechanism of tracheal stem cells

Dormancy activation mechanism of tracheal stem cells

Apolipoproteins and cancer

Wnt signaling in cancer stem cells and colon cancer metastasis

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