<i>Codonopsis lanceolata</i>: A Review of Its Therapeutic Potentials

Hossen, Muhammad Jahangir; Kim, Mi‐Yeon; Kim, Jong-Hoon; Cho, Jae Youl

doi:10.1002/ptr.5553

Cited by 55 publications

(30 citation statements)

References 36 publications

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“…This plant has been broadly used in traditional medicine. The root of C. lanceolata contains various bioactive ingredients–polyphenols, saponins, alkaloids, steroids, tannins, and triterpenes–collectively; and, these are used to treat a broad range of illnesses–bronchitis, cough, spasm, psychoneurosis, cancer, and inflammation (42). Recent studies have revealed that the fermentation process can improve the functional properties of poor quality C. lanceolata .…”

Section: The Effects Of Fermented Foods On Cognitive Functionmentioning

confidence: 99%

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

Kim

Hong

Yang

et al. 2016

JFN

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Around the world, fermentation of foods has been adopted over many generations, primarily due to their commercial significance with enriched flavors and high-profile nutrients. The increasing application of fermented foods is further promoted by recent evidence on their health benefits, beyond the traditionally recognized effects on the digestive system. With recent advances in the understanding of gut-brain interactions, there have also been reports suggesting the fermented food’s efficacy, particularly for cognitive function improvements. These results are strengthened by the proposed biological effects of fermented foods, including neuroprotection against neurotoxicity and reactive oxygen species. This paper reviews the beneficial health effects of fermented foods with particular emphasis on cognitive enhancement and neuroprotective effects. With an extensive review of fermented foods and their potential cognitive benefits, this paper may promote commercially feasible applications of fermented foods as natural remedies to cognitive problems.

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Section: The Effects Of Fermented Foods On Cognitive Functionmentioning

confidence: 99%

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

Kim

Hong

Yang

et al. 2016

JFN

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“…Further studies with larger numbers of subjects are needed. Fourth, phytochemical analysis has shown that CL contains more than 100 compounds, including phenylpropanoids, alkaloids, and triterpenoids (Hossen et al, ). Although we found that CL could prevent HTN in subjects with pre‐HTN, the responsible compounds remain undetermined.…”

Section: Discussionmentioning

confidence: 99%

“…Codonopsis lanceolata (CL) is a vegetable widely used as a traditional medicine for the treatment of bronchitis, cough, abscess, and hyperlipemia (Hossen, Kim, Kim, & Cho, ). It has various physiologically active substances, including triterpenoid saponins (saponins), alkaloids, phenylethanoid glycosides, polyphenols, and polyacetylenes.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial

Shin¹,

Hsieh²,

Han³

et al. 2019

Phytotherapy Research

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Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects.Eighty subjects aged 19-60 years with a systolic blood pressure (BP) of 120-139 mmHg and a diastolic BP of 80-89 mmHg were recruited over 3 months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6 weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p = .038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p = .020) and malondialdehyde (p = .039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.

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“…Deodeok ( Codonopsis lanceolata ) is found in Central, East and South Asia (Hossen, Kim, Kim, & Cho, ). In Republic of Korea, its edible roots are used to make wine, salads, fried foods, kimchi, etc.…”

Section: Introductionmentioning

confidence: 99%

Application of a solvent‐free solid injection technique coupled with GC–MS for discrimination between the secondary metabolites of wild and cultivated South Korean medicinal foods

Truong

El‐Aty

Kim

et al. 2017

Biomedical Chromatography

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Solvent-free solid injection was applied to differentiate between wild and cultivated South Korean medicinal foods, including dureup (Aralia elata), deodeok (Codonopsis lanceolata) and doraji (Platycodon grandiflorus). A number of compounds were identified in wild and cultivated dureup (53 and 46), deodeok (47 and 51) and doraji (43 and 38). Secondary metabolites, including butanal,2-methyl-, β-caryophyllene, neoclovene, α-humulene, γ-curcumene, β-bisabolene, and phytol, were identified in dureup with significantly (P < 0.05) different amounts between both types. In deodeok, squalene and other main components such as acetic acid, methyl ester, furan-methyl-furfural, 2-furan-methanol, and 5-methyl-furfural, were statistically different between the two types. Doraji has significantly different compounds such as furfural, 5-methyl-furfural, 2-methoxy-phenol, 2-methoxy-4-(1-propenyl)-phenol, and 1-(4-hydroxy-3-methoxyphenyl)-2-propanone. Although we failed to confirm the key compounds, a new compound, namely desaspidinol, was synthesized for the first time and its retention index determined under the experimental conditions. This solventless, easy technique can be used as a simple way to discriminate between wild and cultivated types of medicinal plants via identification of volatile markers or specific fingerprints.

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Codonopsis lanceolata: A Review of Its Therapeutic Potentials

Cited by 55 publications

References 36 publications

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial

Application of a solvent‐free solid injection technique coupled with GC–MS for discrimination between the secondary metabolites of wild and cultivated South Korean medicinal foods

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