<i>Colloquium</i>: The quest for high-conductance DNA

Endres, Robert G.; Cox, D. L.; Singh, Rajiv R. P.

doi:10.1103/revmodphys.76.195

Cited by 762 publications

(788 citation statements)

References 101 publications

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“…It becomes then apparent that sample preparation and experimental conditions are more critical than in transport experiments on other nanoscale systems. Meanwhile, a variety of factors that appreciably control charge propagation along the double helix have been theoretically identified: static [10] and dynamical [11] disorder related to random base pair sequences and structural fluctuations, respectively, as well as environmental effects associated with correlated fluctuations of counterions [12] or with the formation of localised states within the bandgap [4,13].Recently, Xu et al [9] have carried out transport experiments on poly(GC) oligomers in aqueous solution. These experiments are remarkable for different reasons: (i) it was shown that transport characteristics of single molecules were probed, (ii) the molecules displayed ohmic-like behavior in the low-bias I-V characteristics and (iii) the linear conductance showed an algebraic dependence g ∼ N −1 on the number N of base pairs.…”

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confidence: 99%

Quantum Transport through a DNA Wire in a Dissipative Environment

2005

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Electronic transport through DNA wires in the presence of a strong dissipative environment is investigated. We show that new bath-induced electronic states are formed within the bandgap. These states show up in the linear conductance spectrum as a temperature dependent background and lead to a crossover from tunneling to thermal activated behavior with increasing temperature. Depending on the strength of the electron-bath coupling, the conductance at the Fermi level can show a weak exponential or even an algebraic length dependence. Our results suggest a new environmentalinduced transport mechanism. This might be relevant for the understanding of molecular conduction experiments in liquid solution, like those recently performed on poly(GC) oligomers in a water buffer (B. Xu et al., Nano Lett. 4, 1105 (2004)).In the emerging field of molecular electronics, DNA oligomers have drawn in the last decade the attention of both experimentalists and theoreticians [1]. This has been mainly motivated by DNA exciting potential applications which include its use as a template in molecular devices or by exploiting its self-assembling and selfrecognition properties [2]. Alternatively, DNA strands might act as molecular wires either in periodic conformations as in poly(GC), or by doping with metal cations as is the case of M-DNA [3]. As a consequence, the identification of the relevant charge transport channels in DNA systems becomes a crucial issue. Transport experiments in DNA derivatives are however quite controversial [4,5]. DNA has been characterized as insulating [6], semiconducting [7] or metallic [8,9]. It becomes then apparent that sample preparation and experimental conditions are more critical than in transport experiments on other nanoscale systems. Meanwhile, a variety of factors that appreciably control charge propagation along the double helix have been theoretically identified: static [10] and dynamical [11] disorder related to random base pair sequences and structural fluctuations, respectively, as well as environmental effects associated with correlated fluctuations of counterions [12] or with the formation of localised states within the bandgap [4,13].Recently, Xu et al. [9] have carried out transport experiments on poly(GC) oligomers in aqueous solution. These experiments are remarkable for different reasons: (i) it was shown that transport characteristics of single molecules were probed, (ii) the molecules displayed ohmic-like behavior in the low-bias I-V characteristics and (iii) the linear conductance showed an algebraic dependence g ∼ N −1 on the number N of base pairs. This latter result suggests the dominance of incoherent charge transport processes. Complex band structure calculations [14] for dry poly(GC) oligomers predict, on the contrary, a rather strong exponential dependence of the conductance on the wire length, a typical result for coherent tunneling through band gaps. Hence,

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confidence: 99%

Quantum Transport through a DNA Wire in a Dissipative Environment

2005

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“…Long distance hole transfer (HT) in DNA is of outstanding importance; the chemico-physical properties of DNA under oxidative stress, 40? as well as the possibility of using DNA in molecular electronics and molecular computing, [41][42][43][44][45] depend on the efficiency with which an electron hole can move along a strand. Steady state photocleavage analyses and time resolved spectroscopical methods have shown that HT can cover distances up to 200 Å before irreversible oxidation takes place.…”

Section: Coherent Hole Transfer In Dnamentioning

confidence: 99%

Vibronic couplings and coherent electron transfer in bridged systems

Borrelli

Capobianco

Landi

et al. 2015

Phys. Chem. Chem. Phys.

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A discrete state approach to the dynamics of coherent electron transfer processes in bridged systems, involving three or more electronic states, is presented. The approach is based on a partition of the Hilbert space of the time independent basis functions in subspaces of increasing dimensionality, which allows for checking the convergence of the time dependent wave function.Vibronic coupling are determined by Duschinsky analysis carried out over the normal modes of the redox partners obtained at high DFT computational level.

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“…Because DNA has a conjugated π electron system, it is expected to be conductive; as a result, many studies have been conducted into the conductivity of DNA. 94,95 Single-molecule analysis methods aim to analyze the base molecules that are contained within a strand of DNA at single-molecule resolutions; they do so using the conductance of individual molecules. Ideally, the base molecules would be analyzed one-by-one as they pass between nanogap electrodes (Figure 20).…”

Section: Single-molecule Analysis Methods For Biopolymersmentioning

confidence: 99%

Single-Molecule Analysis Methods Using Nanogap Electrodes and Their Application to DNA Sequencing Technologies

Taniguchi

2017

Bulletin of the Chemical Society of Japan

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Single-molecule analysis methods facilitate the investigation of the properties of single-molecule junctions (SMJs), in which single molecules are connected between a pair of nanoelectrodes that use nanogap electrodes having a spacing of less than several nanometers. Various methods have been developed to investigate numerous useful parameters for SMJs; for example, the number of molecules connected between a pair of nanoelectrodes can be determined, the types and structures of single molecules can be revealed, localized temperatures within SMJs can be evaluated, and the Seebeck coefficient and the bond strength between single molecules and electrodes can be ascertained. Single-molecule analysis methods have also been used to analyze biopolymers in solutions, and this has resulted in single-molecule sequencing technologies being developed that can determine sequences of base molecules in DNA and RNA along with sequences of amino acids in peptides. Singlemolecule analysis methods are expected to develop into digital analysis techniques that can be used to investigate the physical and chemical properties of molecules at single-molecule resolutions.

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Colloquium: The quest for high-conductance DNA

Cited by 762 publications

References 101 publications

Quantum Transport through a DNA Wire in a Dissipative Environment

Quantum Transport through a DNA Wire in a Dissipative Environment

Vibronic couplings and coherent electron transfer in bridged systems

Single-Molecule Analysis Methods Using Nanogap Electrodes and Their Application to DNA Sequencing Technologies

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