Convolvulus galaticus, Crocus antalyensis, and Lilium candidum Extracts Show Their Antitumor Activity Through Induction of p53-Mediated Apoptosis on Human Breast Cancer Cell Line MCF-7 Cells

Abstract

Conventional and newly emerging treatment procedures such as chemotherapy, catalytic therapy, photodynamic therapy, and radiotherapy have not succeeded in reversing the outcome of cancer diseases to any drastic extent, which has led researchers to investigate alternative treatment options. The extensive repertoire of traditional medicinal knowledge systems from various parts of the world are being re-investigated for their healing properties. It has been reported that several members of the Convolvulaceae, Iridaceae, and Liliaceae families have antitumor activity against some tumor cell lines. Here we first report that Convolvulus galaticus, Crocus antalyensis, and Lilium candidum species have cytotoxic activity on human breast cancer cell line MCF-7 cells. Plant samples were collected and identified, and their cytotoxic effects on the MCF-7 cell line were examined at different concentrations of methanol extracts. We found that all three plants have cytotoxic effects on MCF-7 cells but that C. galaticus has the strongest cytotoxic effect even in the lowest extract concentration tested (0.32 μg/mL). Our results indicate that these plant extracts have cytotoxic effects on human breast carcinoma cell line MCF-7 cells and that this cytotoxic effect comes from p53-mediated stimulation of apoptosis.

Antiproliferative Activity of Some Medicinal Plants on Human Breast and Hepatocellular Carcinoma Cell Lines and their Phenolic Contents

“…Altogether, these results support the traditional use of B. perennis in the treatment of cancer. Although Tokgun et al [22] reported the strongest anti-proliferative activity in methanolic extract of C. galaticus against MCF-7 cell line at low concentration (0.32 mu g/mL), we found that the methanolic extract did not have a notable anti-proliferative activity against MCF-7 cell line. But DCM extract of C. galaticus had a moderate anti-proliferative activity against MCF-7 cell line in our study.…”

“…Furthermore, its flowers are used in the relief of toothache [18,19]. Antibacterial [20,21], antitumor [21] and anticancer activities [22] of C. galaticus have been reported.…”

Antrodia camphorataGrown on Germinated Brown Rice Suppresses Melanoma Cell Proliferation by Inducing Apoptosis and Cell Differentiation and Tumor Growth

“…Increased level of p53 proteins under CBR EtOAc treatment demonstrated that p53 had a major role in apoptotic B16F10 melanoma cell death (Figure 2(c)). Similarly, Tokgun et al reported that medicinal plants of Convolvulus galaticus, Crocus antalyensis , and Lilium candidum extracts showed cytotoxic effect on human breast cancer cells by p53-mediated apoptosis [25]. It seems that CBR EtOAc fraction exerts its antitumor activity through inducing the cellular apoptotic response.…”

Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF‑7 cells

“…Nearly 5.8/100,000 new breast cancer cases are diagnosed in developed countries and >10.5 new breast cancer cases per 100,000 individuals occur worldwide each year (1). In the early stages of the disease, breast cancer, as in case of a number of other cancers, tends to spread asymptomatically throughout the body and at the point of diagnosis there is an increased likelihood of identification of metastatic lesions (2). Conventional therapies, including surgery, radiotherapy and chemotherapy, have served roles in treatment of breast cancer, but there remain numerous problems in tumor therapy.…”