<i>Corynebacterium urealyticum</i> urinary tract infection in a cat with urethral obstruction

Cavana, Paola; Zanatta, Rayssa Ferreira; Nebbia, Patrizia; Miniscalco, Barbara; Vittone, V.; Zanoni, Maria Grazia; Serra, Roberto; Farca, Anna Maria

doi:10.1016/j.jfms.2007.12.003

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…In humans, most CU-UTIs occur in immunocompromised patients with underlying urological disease and in patients with urological manipulations, previous UTIs, prolonged hospitalisation or after treatment with broad-spectrum antibiotics (Aguado et al 1987, Soriano et al 1990). In the veterinary literature, all animals described as having CU-UTI had similar predisposing factors (Elad et al 1992, Gomez et al 1995, Suarez et al 2002 Bailiff et al 2005, Cavana et al 2008, Briscoe et al 2010, Duffy & Gallagher 2018. The present study supports this observation; among our population, many animals combined several predisposing factors.…”

Section: Discussionsupporting

confidence: 89%

“…Fewer than 15 animals with Corynebacterium urealyticum urinary tract infection (CU-UTI) have been described in the peerreviewed veterinary literature, and the largest case series described only seven animals: five dogs and two cats (Bailiff et al 2005). In previous reports, all animals had a factor that may have predisposed to the CU-UTI (Elad et al 1992, Gomez et al 1995, Suarez et al 2002, Bailiff et al 2005, Cavana et al 2008, Briscoe et al 2010, Raab et al 2015, Duffy & Gallagher 2018. Although the typical clinical presentation of encrusted cystitis due to CU has been previously described in veterinary patients, large case series describing or evaluating predisposing factors, clinicopathological findings, ultrasonographic abnormalities, antimicrobial susceptibility and therapeutic outcome are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Maurey

Boulouis

Canonne-Guibert

et al. 2019

J of Small Animal Practice

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Objectives To examine the clinical signs, laboratory findings, possible predisposing factors, antimicrobial sensitivity and outcomes of dogs and cats diagnosed with urinary tract infection caused by Corynebacterium urealyticum. Materials and Methods Retrospective, observational study of dogs and cats that were diagnosed with urinary tract infection caused by C. urealyticum. Results This report concerns a total of 11 dogs and 10 cats. All cats had a history of urethral catheterisation, and six cats had undergone urological surgery before diagnosis of this specific infection. Dogs had history of neurogenic urinary incontinence (n=5), urethral catheterisation (n=4), urological surgery (n=4), lower urinary tract disease (n=2) or prostatic disease (n=1). In seven animals, previous urine culture was negative. Median urine pH was 8.6 (interquartile range 7.5 to 9), and 19 animals had pyuria and struvite crystalluria. Encrusted cystitis was diagnosed by abdominal ultrasound in nine animals. All but one isolate were resistant to at least three antimicrobial classes. Thirteen isolates were sensitive to tetracyclines. There was bacterial and clinical resolution of the infection in nine dogs and seven cats. Two animals died from sepsis and two cats were euthanased because of clinical deterioration. Clinical Significance Urinary tract infection caused by C. urealyticum should be suspected in animals with pre‐existing urinary disorders, especially if urine is alkaline and there is struvite crystalluria, negative routine urine culture and encrusted cystitis.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Maurey

Boulouis

Canonne-Guibert

et al. 2019

J of Small Animal Practice

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“…U rinary tract infections (UTIs) caused by Corynebacterium urealyticum are uncommon in dogs and cats. [1][2][3][4][5][6] Treatment is difficult because C. urealyticum is usually resistant to most antibacterial drugs and the administration of glycopeptide antibacterial drugs is often necessary for successful elimination of this microorganism. 1,[4][5][6][7][8] If the infection is complicated by the development of encrustations and stones within the urinary tract, acidification of the urine and surgical resection of calcified plaques and uroliths may become necessary.…”

mentioning

confidence: 99%

Carbonate apatite nephrolithiasis associated withCorynebacterium urealyticumurinary tract infection in a dog

et al. 2014

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“…Many reports have shown that bacterial UTI are more common in older female dogs, indicating that this is an important risk factor (Kivisto et al, 1977;Bush et al, 1978;Thomsen et al, 1986;Cavana et al, 2008;Sidjabat et al, 2009;Hall et al, 2013;Wong et al, 2015). The mean age at diagnosis regardless of sex is approximately 7-8 years (Ling et al, 2001;Cohn et al, 2003).…”

Section: Epidemiology Of Canine Bacterial Urinary Tract Infectionmentioning

confidence: 99%

“…Risk factors for persistent UTI or reinfection in dogs have also been elucidated (Seguin et al, 2003) (Table 1.2). The age and breeds of dogs with recurrent or persistent UTI varies widely (Table 1.3) and may reflect to some extent breed lifespan and changes in popularity of breeds over time (Cavana et al, 2008). Presence or absence of clinical signs is not consistently reported, thus distinguishing between bacterial cystitis and subclinical bacteriuria episodes is often not possible.…”

Section: Epidemiology Of Canine Bacterial Urinary Tract Infectionmentioning

confidence: 99%

Preventing canine urinary tract infection (UTI) using an asymptomatic bacteriuria (ASB) Escherichia coli strain

Thompson¹

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Bacterial cystitis occurs with reasonable frequency in dogs. Persistent infection and repeated reinfection (recurrent bacterial urinary tract infection, hereafter termed recurrent UTI) is reported less frequently. Recurrent urinary tract infection is predominantly diagnosed in dogs with a predisposing or comorbid condition, and episodes are often subclinical. Escherichia coli is the most frequently cultured species in both uncomplicated bacterial cystitis and recurrent UTI.Antimicrobial therapy limitations and global emergence of bacterial strains that are both virulent and multidrug-resistant (MDR) has led to an urgent requirement for novel control strategies in both companion animals and humans. Escherichia coli strain 83972 has been successfully used to colonise the bladder of humans with recurrent UTI in order to reduce the incidence of subsequent febrile UTI via the process of active bacterial interference. This strategy has not been utilised in dogs to date but may prove an effective alternative to antimicrobial therapy if it can be shown to colonise the bladder of dogs safely and effectively compete with uropathogens.A retrospective study to examine the signalment, infecting strains, presence of clinical signs, and incidence of pyuria in Australian dogs with recurrent urinary tract infection was performed. The findings were similar to those of two large North-American studies with regard to signalment, predisposing or comorbid diseases, bacterial species isolated, and resistance to commonly used oral antimicrobials, although the median age of our dogs was higher at 10 years (7 years in both prior studies). Examination of the E. coli isolates from a subset of nine dogs provided new information on phylogenetic group, virulence gene profiles, haemolytic phenotype, expression of type 1 fimbriae, and sequence type (ST). Phylogenetic groups F and B2 were frequently identified, representing 13/32 (41%) and 8/32 (25%) of isolates respectively, but no phylogroup B2 isolates were MDR, in comparison with phylogroup F isolates, which accounted for 12/16 (75%) MDR isolates. Clonal groups of global importance such as ST131-B2, ST354-F, ST38-D and ST457-F were represented, with possible implications for both companion animal and human health. Of particular concern was the repeated isolation of ST354-F strains from the urine of a paralysed dog over a 3-year period.When competition experiments between E. coli 83972 and a selection of canine uropathogenic E. coli (UPEC), including emerging, highly virulent MDR strains with zoonotic potential, were performed in pooled canine urine, E. coli 83972 was largely non-competitive against the canine isolates after 17 hr of incubation. This finding contrasted with the competitive superiority previously exhibited by E. coli 83972 in pooled human urine in competition experiments with human UPEC strains. In 5/10 trials, the E. coli 83972 was not outcompeted in canine urine, iii however, and given that the starting ratio in dogs following prophylactic bladder colonisation would ...

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Corynebacterium urealyticum urinary tract infection in a cat with urethral obstruction

Cited by 23 publications

References 17 publications

Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Carbonate apatite nephrolithiasis associated withCorynebacterium urealyticumurinary tract infection in a dog

Preventing canine urinary tract infection (UTI) using an asymptomatic bacteriuria (ASB) Escherichia coli strain

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