Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample

Abstract

Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development. Genetic polymorphisms of COX-2 and IL-10 might contribute to the development of squamous cell carcinoma of the head and neck (SCCHN). The purpose of this study was to evaluate the association of COX-2 and IL-10 single nucleotide polymorphisms (SNPs) with the risk of SCCHN in a Korean sample. We analyzed the COX-2 SNPs, -1329A>G, +1266C>T, and +6365T>C, and the IL-10 SNPs, -1082A>G, +920T>G, and +3917T>C, in 290 Korean SCCHN patients and 358 healthy controls. There was no significant association between the risk of SCCHN and the three COX-2 or three IL-10 SNPs. We analyzed three haplotypes (ht1, ht2, ht3) for COX-2 and found that COX-2 ht3+/+ was associated with a decreased risk of SCCHN in a Korean sample, compared with the COX-2 ht3 -/- genotype (P=0.03). Two haplotypes (ht1, ht2) of IL-10 were analyzed and there was no statistical significance in the distribution of haplotypes. Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample.

Increased risks between Interleukin-10 gene polymorphisms and haplotype and head and neck cancer: a meta-analysis

“…Ultimately, nine studies 29 37 38 39 40 41 42 43 44 satisfied the outlined inclusion criteria and characteristics ( Table 1 and Supplemental Table S4 online), including the quality assessment score that was generated based on the Newcastle-Ottawa Scale of studies. Each of the nine studies focused on the association of the −1082A > G polymorphism with HNC risk 29 37 38 39 40 41 42 43 44 , and six studies investigated the association of the −819T > C and −592A > C variants with HNC risk 29 37 39 42 43 44 . Three studies focused on Caucasian populations 29 38 40 , and six studies focused on Asian populations 37 39 41 42 43 44 .…”

Interleukin‐10promoter variants predict HPV‐positive tumors and survival of squamous cell carcinoma of the oropharynx

“…An association between IL-10 rs1800872 and cervical cancer has been found, and no association with prostate cancer was detected for IL-10 rs1800871 (31,32). Thus far, only one other study has evaluated the association of IL-10 polymorphisms with risk of head and neck cancers in a Korean population, but no association was detected between the three main polymorphisms and the risk of head and neck cancers (33). Several studies have demonstrated that IL-10 polymorphisms are associated with HPV clearance.…”

Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer

“…In addition to functional SNPs, tag SNPs were selected for the six prostaglandin pathway genes. Data of Han Chinese in Beijing surveyed by the HapMap Project (Jeong et al , ) were downloaded using Haploview (Barrett et al , ), and the Tagger program (de Bakker, ) was used to select tag SNPs for each gene with r 2 set at 0.8. 10‐kb regions upstream and downstream of each gene were included to cover variants in potential regulatory elements.…”

“…All of the seven previous studies on the association between genetic polymorphisms of the PG pathway and HNC risk have only included PTGS2 (COX‐2) (Chiang et al , ; Lin et al , ; Peters et al , ; Jeong et al , ; Mittal et al , ; Lakshmi et al , ; Niu et al , ). In the present study, we conducted a comprehensive investigation of genetic polymorphisms of six genes ( PGDS, PTGDS, PTGES, PTGIS, PTGS1, and PTGS2 ) in the PG pathway and examined their association with HNC risk.…”