COX2 and NOS3 gene polymorphisms in women with gestational diabetes

Abstract

The results of the present study suggest that the CC genotype of the COX2 rs6681231 polymorphism is associated with an increased risk of GDM and the need for insulin therapy, whereas the TT genotype of the NOS3 rs1799983 polymorphism may be associated with the need for insulin therapy in women with GDM.

Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes

“…In previous studies, the association between polymorphisms and gestational diabetes was studied in three models: additive (number of variant alleles = 0, 1, or 2 for each subject), dominant (variant homozygotes and heterozygotes vs. wildtype homozygotes) and recessive (variant homozygotes vs. heterozygotes and wildtype homozygotes) [10][11][12][13][14][15][16][17]. The best fit was observed for the additive model.…”

“…Therefore the additive model of genotype-phenotype association was selected for all polymorphisms in this study as it was the simplest and the most appropriate. All polymorphisms that were significantly associated with GDM in univariate analyses in previous studies [10][11][12][13][14][15][16][17] were included as independent variables in the current study.…”

“…Genotypes were assigned using all data from the study simultaneously. Details of genotyping methods are described in previous papers [10][11][12][13][14][15][16][17].…”

“…Therefore genetic variants associated with type 2 diabetes may also be associated with an increased risk of GDM [9]. Previous studies have examined the associations between several genetic polymorphisms involved in carbohydrate and lipid metabolism [i. e., PTGS2 (COX2) rs6681231, FADS1 rs174550, HNF1B rs4430796, ADIPOQ rs266729, IL18 rs187238, CCL2 rs1024611, HHEX rs5015480 and CDKN2A/2B rs10811661] and GDM [10][11][12][13][14][15][16][17]. Some of these polymorphisms were associated with an increased risk of GDM development or with clinical parameters in pregnant women (i. e., BMI before pregnancy, BMI at birth, weight increase during pregnancy, BMI increase during pregnancy, HbA1c, daily insulin requirement, and duration of labour) or new-born babies (body mass at birth and APGAR score).…”

Polymorphisms of TGF-β1 and TGF-β3 in Chinese Women With Gestational Diabetes Mellitus

“…The major genetic studies of GDM are candidate gene studies, which have revealed that some single nucleotide polymorphisms (SNPs) in cytokine genes are associated with susceptibility to GDM [12,13]. SNPs within the coding and signal sequences can affect gene transcriptional activity, and then change the production of proteins [14]. Several studies have reported that altered cytokines expression are related to the severity and progression of the GDM [15,16].…”