<i>Cryptosporidium</i>Rabbit Genotype, a Newly Identified Human Pathogen

Chalmers, Rachel M.; Robinson, Guy; Elwin, Kristin; Hadfield, Stephen J.; Xiao, Lihua; Ryan, Una; Modha, Deborah; Mallaghan, Catherine

doi:10.3201/eid1505.081419

Cited by 123 publications

(117 citation statements)

References 8 publications

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“…Cryptosporidium cuniculus was initially thought to be hostspecific until the discovery that C. cuniculus was linked to a human cryptosporidiosis outbreak in the UK (Chalmers et al 2009b), which raised considerable awareness about the importance of investigating rabbits as a source of Cryptosporidium transmissible to humans. Subsequently, a study reported that C. cuniculus was the third most commonly identified Cryptosporidium species in patients with diarrhoea in the UK (Chalmers et al 2011a).…”

Section: Cryptosporidium In Wild Mammalsmentioning

confidence: 99%

Cryptosporidiumspecies in humans and animals: current understanding and research needs

2014

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S U M M A R YCryptosporidium is increasingly recognized as one of the major causes of moderate to severe diarrhoea in developing countries. With treatment options limited, control relies on knowledge of the biology and transmission of the members of the genus responsible for disease. Currently, 26 species are recognized as valid on the basis of morphological, biological and molecular data. Of the nearly 20 Cryptosporidium species and genotypes that have been reported in humans, Cryptosporidium hominis and Cryptosporidium parvum are responsible for the majority of infections. Livestock, particularly cattle, are one of the most important reservoirs of zoonotic infections. Domesticated and wild animals can each be infected with several Cryptosporidium species or genotypes that have only a narrow host range and therefore have no major public health significance. Recent advances in next-generation sequencing techniques will significantly improve our understanding of the taxonomy and transmission of Cryptosporidium species, and the investigation of outbreaks and monitoring of emerging and virulent subtypes. Important research gaps remain including a lack of subtyping tools for many Cryptosporidium species of public and veterinary health importance, and poor understanding of the genetic determinants of host specificity of Cryptosporidium species and impact of climate change on the transmission of Cryptosporidium.

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Section: Cryptosporidium In Wild Mammalsmentioning

confidence: 99%

Cryptosporidiumspecies in humans and animals: current understanding and research needs

2014

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“…Although the first report of rabbit Cryptosporidium was noticed in 1912 (Tyzzer 1912), the concerns regarding Cryptosporidium infection in rabbits have only occurred in recent years due to a few sporadic human cases and a serious waterborne outbreak of cryptosporidiosis caused by Cryptosporidium cuniculus (previously named as Cryptosporidium rabbit genotype) (Chalmers et al 2009;Molloy et al 2010;Robinson et al 2008).…”

Section: Introductionmentioning

confidence: 99%

An Epidemiological Study on Endoparasites of Domestic Rabbits (Oryctolagus cuniculus) in Egypt with Special Reference to Their Health Impact

Elshahawy¹,

El-Goniemy²

2018

JSM

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“…In Egypt, it is reported as a virulent agent of diarrhea especially in childhood with varied prevalence (Youssef et al 2008). It can infect a wide range of many vertebrates, including humans (Chalmers et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Laboratory utility of coproscopy, copro immunoassays and copro nPCR assay targeting Hsp90 gene for detection of Cryptosporidium in children, Cairo, Egypt

et al. 2014

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Cryptosporidium is a significant cause of diarrhea worldwide especially in children. Infection may end fatally in immunocompromised patients. Multi-attribute analysis was used to determine the lab utility of 4 diagnostics; coproscopy of AF stained fecal smear, fecal immunoassays by ICT and ELISA and copro-nPCR assay targeting Hsp90 gene, for detection of Cryptosporidium in stool of 250 Egyptian children (150 diarrheic and 100 nondiarrhaeic children). Also, to determine Cryptosporidium molecular prevalence. Cryptosporidium was an important enteric pathogen among both diarrheic and non-diarrheic study children with a clearly high prevalence of 16.4 % (n = 41). Conventional methods had perfect specificity (100 %) but couldn't be used as a consistent single detection method due to their lowered sensitivities. Multiattribute analysis ranked nPCR the highest test for lab use. Being the test with the best diagnostic yield, nPCR is a reliable diagnostic test and is going to replace conventional methods for reliable detection of Cryptosporidium.

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CryptosporidiumRabbit Genotype, a Newly Identified Human Pathogen

Cited by 123 publications

References 8 publications

Cryptosporidiumspecies in humans and animals: current understanding and research needs

Cryptosporidiumspecies in humans and animals: current understanding and research needs

An Epidemiological Study on Endoparasites of Domestic Rabbits (Oryctolagus cuniculus) in Egypt with Special Reference to Their Health Impact

Laboratory utility of coproscopy, copro immunoassays and copro nPCR assay targeting Hsp90 gene for detection of Cryptosporidium in children, Cairo, Egypt

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