Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Abstract

This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant (p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly (p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma (p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.

Prevalence of Hypertension and Associated Factors among Patients Attending Hoima Regional Referral Hospital, Hoima District Western Uganda

“…Obese participants were more likely to have hypertension. This was in agreement with other previous studies, which reported an association between obesity and high blood pressure [21,22]. Obesity is a well-established risk factor for hypertension.…”

Ameliorative Potential of Pumpkin Seed Oil (Cucurbita pepo L.) Against Tramadol-Induced Oxidative Stress

“…The rats subsequently received the same CPSO dose followed by the same observation/monitoring, which continued for an additional 14 days to watch for possible toxicity. 34,35 At the 50 mL/kg limit test dose, there were no signs of gross behavioral or physical changes in the rats, such as motor activity, reduction in feeding, or hair erection during the 24-hour and 14-day monitoring periods. Consequently, 5 mL/kg limit dose (10%) was chosen as the intermediate/middle dose, 2.5 mL/kg (half of this) was chosen as the lower dose, while 7.5 mL/kg (1.5 times the middle dose) was chosen as the higher dose according to the guideline of OECD (20080) as stated in the OECD guideline No.…”

Improving Health through Sustainable and Healthy Urban Food System Policy in Nigeria

“…The Igbo food system is traditionally styled in that it utilizes raw foodstuffs to make various meals, as highlighted in Table 1 [15], instead of processed and packaged foods. Some of these raw foodstuffs, especially vegetables and seed oils, have been reported to possess therapeutic properties such as glucose-and lipid-lowering potentials [16,17]. Fruits and vegetables (FVs) form the basis of adequate dietary patterns globally.…”