Cuminum cyminumextract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: A noninvasive biochemical approach

Koppula, Sushruta; Choi, Dong‐Kug

doi:10.3109/13880209.2010.541923

Cited by 50 publications

(31 citation statements)

References 47 publications

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“…CCY extract effectively improved antioxidant enzyme activities in MPTP treated animals especially at the dose of 300 mg/kg. The anti-oxidant effects observed in this study were in agreement with our earlier reported works, that C. cyminum extract has ability to scavenge free radicals [6,10].…”

Section: Discussionsupporting

confidence: 82%

“…Pharmacologically, C. cyminum has been reported to possess anti-diabetic, anti-bacterial, hepatoprotective, neuroprotective, anti-epileptic, hypolipidemic, anti-stress anti-oxidant and memory -enhancing properties [5][6][7]. Recently, C. cyminum was also reported to exhibit potent immunomodulatory, nephroprotective, anti-stress and memory enhancing properties [8][9][10]. But so far their protective effect in neurodegenerative disorders such as PD has not been studied.…”

Section: Cuminum Cyminum Linn (Cmentioning

confidence: 99%

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Cuminum cyminum Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

Kim¹,

Kopalli²,

Koppula³

2016

Trop. J. Pharm Res

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Purpose: To evaluate the protective effects of Cuminum cyminum Linn (Apiaceae, CCY) against 1-methyl-4 phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced oxidative stress and behavioral impairments in mouse model of Parkinson's disease (PD). Methods: MPTP-intoxicated mice model of PD was used for evaluating the effect of CCY extract on behavioral deficits through rota rod, passive avoidance and open field tasks. The effect of CCY extract on oxidative stress levels were assessed by estimating enzyme status, including superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation(LPO) in brain tissues

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Section: Discussionsupporting

confidence: 82%

Section: Cuminum Cyminum Linn (Cmentioning

confidence: 99%

Cuminum cyminum Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

Kim¹,

Kopalli²,

Koppula³

2016

Trop. J. Pharm Res

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“…For example, cumin extract was found to have nootropic effects and to attenuate scopolamine-induced amnesia in rats [24]. Cumin essential oil attenuated morphine-induced conditioned place preference [25] and this effect was suggested to involve inhibition of the central nitric oxide synthesis [26].…”

Section: Cuminaldehyde Possesses Neuroprotective Effectsmentioning

confidence: 99%

Cuminaldehyde: A Potential Drug Candidate

Ebada¹

2017

JPCR

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Cuminaldehyde is one of major constituents identified in the essential oil of a number of commonly used spices such as green cumin (Cuminum Cyminum L.) which has been traditionally used for the treatment of dyspepsia, diarrhea, abdominal colic and Jaundice. Cumin essential oil has multiple pharmacological actions including antioxidant, antidiabetic, anti-inflammatory, antibacterial and anticancer effects. Therefore, a great deal of attention has been given to investigate the role of cuminaldehyde in mediating cumin's multiple therapeutic benefits. This short review highlights the most significant recently reported findings which unravel the extent to which cuminaldehyde contributes to the therapeutic effects of its producing herbs. Apart from its non-medical effects as natural bio-fumigant, cuminaldehyde is a promising potential drug candidate against various diseases.

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“…It was significantly effective on expression of morphine tolerance (1 and 2%) and dependence (0.5, 1 and 2%) in a dose-dependent manner. Accordingly, the essential oil of Cuminum cyminum ameliorated the morphine tolerance and dependence in mice [126].…”

Section: Cuminum Cyminummentioning

confidence: 99%