<i>Curcumin longa</i> extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release

Ahn, Min Young; Hwang, Jae Joon; Lee, Su Bi; Ham, Sun Ah; Hur, Joon; Kim, Jun Tae; Seo, Han Geuk

doi:10.7717/peerj.3808

Cited by 14 publications

(15 citation statements)

References 31 publications

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“…Ahn et al () found that curcumin has the ability to suppress NO signaling and reduce the release of the proinflammatory cytokine.…”

Section: Resultsmentioning

confidence: 99%

“…There was also an increase in the phosphorylation of p38 and caspase-3 activity. Ahn et al (2017) found that curcumin has the ability to suppress NO signaling and reduce the release of the proinflammatory cytokine. Yuan et al (2012) have investigated the effects of curcumin on triggering receptor expressed on myeloid cells 1 (TREM-1) expression in response to LPS.…”

Section: In Vitro Studiesmentioning

confidence: 99%

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Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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“…Ahn et al () found that curcumin has the ability to suppress NO signaling and reduce the release of the proinflammatory cytokine.…”

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Studiesmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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“…Several phytochemicals have been shown to alleviate the sepsis during interfering with the release and action of HMGB1. (I) resveratrol inhibits the cytoplasmic translocation of HMGB1; (II) resveratrol, 56,57 curcumin, 95 quercetin, 42 and glycyrrhizin 24 decrease the level of HMGB1; and (III) glycyrrhizin directly binds HMGB1 and inhibits its binding to RAGE and TLR4 24,25 …”

Section: Discussionmentioning

confidence: 99%

“…in vivo studies also showed that the curcumin nanoemulsion increased the survival rate by up to 50% in LPS‐challenged mice. This was attributed to blocking NO signaling as was evidenced by a dramatic decrease of circulatory HMGB1, as well as reduced expression of iNOS in kidney, lung, heart, and liver tissues of endotoxemic mice 95 …”

Section: Treatment Of Sepsis With Polyphenolic Compoundsmentioning

confidence: 99%

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

et al. 2020

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Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1). In severe sepsis, the overwhelming production of pro‐inflammatory cytokines and reactive oxygen species may compromise organ function and lead to the induction of abnormal apoptosis in different organs, resulting in multiple organ dysfunction syndrome and death. Hence, compounds that are able to attenuate inflammatory responses may have therapeutic potential for sepsis treatment. Understanding the pathophysiology and underlying molecular mechanisms of sepsis may provide useful insights in the discovery and development of new effective therapeutics. Therefore, numerous studies have invested much effort into elucidating the mechanisms involved with the onset and development of sepsis. The present review mainly focuses on the molecules and signaling pathways involved in the pathogenicity of sepsis. Additionally, several well‐known natural bioactive herbal compounds and phytochemicals, which have shown protective and therapeutic effects with regard to sepsis, as well as their mechanisms of action, are presented. This review suggests that these phytochemicals are able to attenuate the overwhelming inflammatory responses developed during sepsis by modulating different signaling pathways. Moreover, the anti‐inflammatory and cytoprotective activities of phytochemicals make them potent compounds to be included as complementary therapeutic agents in the diets of patients suffering from sepsis in an effort to alleviate sepsis and its life‐threatening complications, such as multi‐organ failure.

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“…Administration of neutralizing antibodies or antagonists to HMGB1 ameliorated the inflammation‐associated symptoms in sepsis, ischemic reperfusion, and colitis (Andrassy et al., 2008; Davé et al., 2009; Wang et al., 1999). Recent studies demonstrated that extracts derived from medicinal herbs such as Curcumin longa and Dalbergia odorifera , ameliorates the LPS‐triggered lethality in the endotoxemia mouse model through nitric oxide (NO) signal‐mediated regulation of HMGB1 release (Ahn, Hwang, Lee, et al., 2017; Choi et al., 2017). Furthermore, formononetin, a herbal isoflavonoid, inhibited LPS‐triggered release of HMGB1 by upregulating SIRT1 (sirtuin 1; silent mating type information regulation 2 homologue 1) in a peroxisome proliferator‐activated receptor (PPAR)δ‐dependent manner (Hwang et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Ginseng leaf extract ameliorates the survival of endotoxemic mice by inhibiting the release of high mobility group box 1

et al. 2021

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High mobility group box 1 (HMGB1) is a well‐defined mediator involved in the pathophysiologic response to endotoxemia and sepsis. However, the mechanisms and therapeutic agents that could prevent its release are not fully elucidated. Here, the present study demonstrates that the ginseng leaf extract (GLE) regulates lipopolysaccharide (LPS)‐triggered release of HMGB1 in macrophages and endotoxemic animal model. Treatment of RAW264.7 macrophages with GLE significantly inhibited the release of HMGB1 stimulated by LPS. GLE also suppressed the generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) in a dose‐dependent manner. These effects of GLE were accompanied by inhibition of HMGB1 release stimulated by LPS, indicating a potential mechanism by which GLE regulates HMGB1 release through NO signaling. Furthermore, induction of suppressor of cytokine signaling 1 by GLE‐mediated GLE‐dependent suppression of HMGB1 release and NO/iNOS induction by inhibiting Janus kinase 2/signal transducer and activator of transcription 1 signal in RAW 264.7 cells exposed to LPS. Finally, administration of the GLE ameliorated the survival rate of LPS‐injected endotoxemic mice in a NO‐dependent manner. Thus, GLE may block the LPS‐stimulated release of HMGB1 by regulating cellular signal networks, thereby providing a therapeutic strategy for endotoxemia as a functional food. Practical applications High mobility group box 1 (HMGB1) is released into the extracellular milieu when immune cells are exposed to pathogen‐related molecules such as lipopolysaccharide (LPS), in which it acts as a critical mediator of lethality in sepsis and endotoxemia. The extract of ginseng leaf, which is a part that can be easily thrown away, ameliorated the survival rate of endotoxemic mice by inhibiting HMGB1 secretion in a NO‐dependent manner. Thus, this study suggests that ginseng leaf can be used as a functional food by resolving the immune responses in the pathology of endotoxemia.

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Curcumin longa extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release

Cited by 14 publications

References 31 publications

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

Ginseng leaf extract ameliorates the survival of endotoxemic mice by inhibiting the release of high mobility group box 1

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