CYP2D6 's Functional Status Associated with the Length of Hospitalization Stay in Psychiatric Patients: A Twist in the Tale or Evidence that Matters?

Abstract

A letter in response to: Ruaño G, Szarek BL, Villagra D et al. Length of psychiatric hospitalization is correlated with CYP2D6 functional status in inpatients with major depressive disorder. Biomarkers Med. 7(3), 429–439 (2013).

CYP2D6 genotypes in revolving door patients with bipolar disorders

“…The RD condition was defined for those patients having a minimum of 4 admissions, and no admission or discharge period lasting for more than 1/4 of the observation period or at least 4 admissions over the first 1/4 of the observation period. [ 13 ] The time lapse in which the RD condition was defined is summarized in Table 1 . To avoid bias in RD evaluation, that is, any clinical or social needs that aggravate the disease or to explain disease exacerbation, possibly miming/exacerbating the RD condition, the Camberwell Assessment of Need (CAN) rating scale [ 33 ] was administered to each patient.…”

“…Previous studies have correlated the length of psychiatric hospitalization with cytochrome P450 (CYP)2D6 (CYP2D6) functional status. [ 12 , 13 ] However, the recurring nature of the psychopathological course of psychiatric illnesses, together with the unwanted outcomes observed in these patients, are probable the major responsible of the revolving door (RD) condition, a periodical hospital readmission without any substantial improvements in psychiatric symptoms, [ 14 ] further increasing costs for their clinical management.…”