<i>Datura</i> and <i>Brugmansia</i> plants related antimuscarinic toxicity: an analysis of poisoning cases reported to the Taiwan poison control center

Doan, Uyen Vy; Wu, Ming; Phua, Dong Haur; Rojas, Bomar Mendez; Yang, Chen Chang

doi:10.1080/15563650.2018.1513527

Cited by 19 publications

(23 citation statements)

References 36 publications

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“…This prolonged intoxication may increase the likelihood that the user will present and require treatment at an emergency department 90,91 . Anticholinergic effects such as xerostomia, delirium, confusion, difficulty swallowing, and blurred vision are likely to occur first, followed by the psychoactive effects 92 …”

Section: Mixed Serotonin and Dopamine Reuptake Inhibitors And Releasersmentioning

confidence: 99%

“…While complete recovery is typical with supportive care, multiple fatal ingestions have been reported 88,134 . The acetylcholinesterase inhibitor physostigmine may be administered as an antidote 91,92 . Physostigmine has demonstrated the ability to reverse delirium and control agitation within ≈5 to 15 minutes in the majority of patients who present with anticholinergic toxicity and may shorten recovery time 92,135 .…”

Section: Mixed Serotonin and Dopamine Reuptake Inhibitors And Releasersmentioning

confidence: 99%

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Pharmacologic Similarities and Differences Among Hallucinogens

Waters

2021

The Journal of Clinical Pharma

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Hallucinogens constitute a unique class of substances that cause changes in the user's thoughts, perceptions, and mood through various mechanisms of action. Although the serotonergic hallucinogens such as lysergic acid diethylamide, psilocybin, and N,N‐dimethyltryptamine have been termed the classical hallucinogens, many hallucinogens elicit their actions through other mechanisms such as N‐methyl‐D‐aspartate receptor antagonism, opioid receptor agonism, or inhibition of the reuptake of monoamines including serotonin, norepinephrine, and dopamine. The aim of this article is to compare the pharmacologic similarities and differences among substances within the hallucinogen class and their impact on physical and psychiatric effects. Potential toxicities, including life‐threatening and long‐term effects, will be reviewed.

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Section: Mixed Serotonin and Dopamine Reuptake Inhibitors And Releasersmentioning

confidence: 99%

Section: Mixed Serotonin and Dopamine Reuptake Inhibitors And Releasersmentioning

confidence: 99%

Pharmacologic Similarities and Differences Among Hallucinogens

Waters

2021

The Journal of Clinical Pharma

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“…A psicopatologia da ingestão de B. suaveolens é centrada em alcalóides tropânicos, principalmente a hioscina, a escopolamina e a atropina (Barreto, 2016;Doan et al, 2019). Tais alcalóides induzem inibição da atividade de receptores muscarínicos no sistema nervoso central e periférico, resultando em toxicidade anticolinérgica e como consequência sintomas, tais quais a confusão, delírio, alucinações, visão embaçada, midríase, retenção urinária, febre, colapso cardiorrespiratório, coma e morte (Soulaidopoulos et al, 2017).…”

Section: Alterações Psíquicas Da Brugmansia Suaveolensunclassified

Consumo de Brugmansia suaveolens (Trombeta de Anjo) e perturbação psíquica

Silva

Ono²,

Monteiro

et al. 2021

RSD

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A planta Brugmansia suaveolens (Humb. & Bonpl. ex Willd.) Sweet, conhecida popularmente como “Trombeta de Anjo”, é típica de regiões tropicais e sul americanas, incluindo o Brasil, e é famosa por suas propriedades alucinógenas, perturbadoras, sedativas, entre outras. Neste contexto, é utilizada em práticas ritualísticas, curativas e recreacionais. Dessa maneira, o presente estudo tem como objetivo analisar e discutir o consumo de B. suaveolens e o seu potencial de perturbação psíquica. Fez-se uma revisão bibliográfica integrativa, utilizando-se de artigos dos últimos 10 anos (2010-2020), com os descritores “Brugmansia suaveolens”, “Toxinas”, “Alucinações”, “Delirium”, “Síndrome Anticolinérgica Aguda”, “Escopolamina”, “Atropina”, “Chá de Trombeta”, “Trombeta de Anjo”, “Mududu”. A Brugmansia suaveolens apresenta propriedades antinociceptiva, nematicida e relaxante muscular e a toxicidade do seu consumo é dose dependente. Neste sentido, concentrações maiores de flores na infusão de água refletem em maiores concentrações de atropina e escopolamina, os quais inibem os receptores muscarínicos. Esta inibição é responsável pela toxicidade anticolinérgica, causando febre, alucinações, confusão, delírio, dentre outros sintomas. Conclui-se que a utilização de B. suaveolens apresenta riscos, devido ao seu alto potencial alucinógeno, e deve ser visto, portanto, com importância clínica.

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“…In another study, a scopolamine concentration of 149.80 ± 6.01 µg/mL was determined in the flower nectar [ 37 ]. The plant parts that are the most involved in poisoning are flowers (77.5%), leaves (13.4%), fruits (4.5%), stem (2.3%), and root (2.3%) [ 60 ].…”

Section: Toxicitymentioning

confidence: 99%

“…The signs and symptoms of Angel’s Trumpet poisoning are mydriasis, dry mouth, delirium, reddened skin [ 61 ], dry skin [ 60 ], agitation/aggressiveness, reduced bowel sounds [ 61 ], ileal paralysis, drowsiness [ 62 ], visual hallucinations, tachycardia, urinary retention, fever, increased systolic blood pressure, a Glasgow Coma Scale (GCS) of <12, [ 61 ], vertigo [ 60 ], decreased temperature and difficulty breathing prior to coma [ 3 ].…”

Section: Toxicitymentioning

confidence: 99%

Chemical Compounds, Pharmacological and Toxicological Activity of Brugmansia suaveolens: A Review

Petricevich¹,

Salinas-Sánchez

Avilés-Montes

et al. 2020

Plants

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This study investigates updated information in different search engines on the distribution, phytochemistry, pharmacology, and toxicology of Brugmansia suaveolens (Solanaceae) using the extracts or chemical compounds at present. This plant has been used in traditional medicine in different cultures as a hallucinatory, analgesic, aphrodisiac, nematicide, sleep inducer, and muscle relaxant, as well as a treatment for rheumatism, asthma, and inflammation. The flowers, fruits, stems, and roots of the plant are used, and different chemical compounds have been identified, such as alkaloids, volatile compounds (mainly terpenes), coumarins, flavonoids, steroids, and hydrocarbons. The concentration of the different compounds varies according to the biotic and abiotic factors to which the plant is exposed. The toxic effect of the plant is mainly attributed to atropine and scopolamine, their averages in the flowers are 0.79 ± 0.03 and 0.72 ± 0.05 mg/g of dry plant, respectively. Pharmacological studies have shown that an aqueous extract exhibits the antinociceptive effect, at doses of 100 and 300 mg/kg i.p. in mice. On the other hand, the ethanolic extract at 1000 mg/L, showed a nematocidal activity in vitro of 64% against Meloidogyne incognita in 72 h. Likewise, it showed a 100% larvicidal activity at 12.5 mg/L against Ancylostoma spp. In another study, the lethal activity of shrimp in brine from an ethanolic extract showed an LC50 of 106 µg/mL at double serial concentrations of 1000–0 (µg/mL). Although there are pharmacological and phytochemical studies in the plant, they are still scarce, which has potential for the examination of the biological activity of the more than one hundred compounds that have been reported, many of which have not been evaluated.

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Datura and Brugmansia plants related antimuscarinic toxicity: an analysis of poisoning cases reported to the Taiwan poison control center

Cited by 19 publications

References 36 publications

Pharmacologic Similarities and Differences Among Hallucinogens

Pharmacologic Similarities and Differences Among Hallucinogens

Consumo de Brugmansia suaveolens (Trombeta de Anjo) e perturbação psíquica

Chemical Compounds, Pharmacological and Toxicological Activity of Brugmansia suaveolens: A Review

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