<i>De Novo</i> delayed onset hypothermia secondary to therapeutic doses of risperidone in bipolar affective disorder

Perera, Minoli; Yogaratnam, Jegan

doi:10.1177/2045125313507740

Cited by 13 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exact mechanism of antipsychotics causing hypothermia is unknown. It has been considered that drugs with stronger 5-HT2a than D2 antagonism are more likely to induce hypothermia than other antipsychotics [Kreuzer et al 2012; Perera and Yogaratnam, 2014; van Marum et al 2007]. In our case, we propose the combination of two drugs with strong 5-HT2 antagonism as the cause.…”

Section: Discussionmentioning

confidence: 80%

“…Thus, we do not regard it as the cause of hypothermia. Pipamperone, which was started 5 days before the onset of hypothermia, has a half-life of about 17–22 h, and is known to cause hypothermia [Eikenboom et al 1997; Schwaninger et al 1998], as well as risperidone [Kreuzer et al 2012; Perera and Yogaratnam, 2014], which the patient has been receiving on admission in a stable dosage.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypothermia in a patient with Alzheimer’s disease receiving a combination therapy with risperidone and pipamperone

Kamp

Paschali

Supprian

et al. 2015

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Hypothermia in a patient with Alzheimer’s disease receiving a combination therapy with risperidone and pipamperone

Kamp

Paschali

Supprian

et al. 2015

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

“…Bromocriptine mesylate, a potent agonist at D 2 receptor, could be used to control central hyperthermia [40]. Furthermore, RIS has stronger affinity for 5-HT 2A receptor than for D 2 receptor [6,41]. Bromocriptine mesylate induces hypothermia and reduces neuronal damage after global ischemia in rats [42].…”

Section: Discussionmentioning

confidence: 99%

Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress

Yang

Tae

Lee

et al. 2019

IJMS

View full text Add to dashboard Cite

Compelling evidence from preclinical and clinical studies has shown that mild hypothermia is neuroprotective against ischemic stroke. We investigated the neuroprotective effect of post-risperidone (RIS) treatment against transient ischemic injury and its mechanisms in the gerbil brain. Transient ischemia (TI) was induced in the telencephalon by bilateral common carotid artery occlusion (BCCAO) for 5 min under normothermic condition (37 ± 0.2 °C). Treatment of RIS induced hypothermia until 12 h after TI in the TI-induced animals under uncontrolled body temperature (UBT) compared to that under controlled body temperature (CBT) (about 37 °C). Neuroprotective effect was statistically significant when we used 5 and 10 mg/kg doses (p < 0.05, respectively). In the RIS-treated TI group, many CA1 pyramidal neurons of the hippocampus survived under UBT compared to those under CBT. In this group under UBT, post-treatment with RIS to TI-induced animals markedly attenuated the activation of glial cells, an increase of oxidative stress markers [dihydroethidium, 8-hydroxy-2′ -deoxyguanosine (8-OHdG), and 4-Hydroxynonenal (4-HNE)], and a decrease of superoxide dismutase 2 (SOD2) in their CA1 pyramidal neurons. Furthermore, RIS-induced hypothermia was significantly interrupted by NBOH-2C-CN hydrochloride (a selective 5-HT2A receptor agonist), but not bromocriptine mesylate (a D2 receptor agonist). Our findings indicate that RIS-induced hypothermia can effectively protect neuronal cell death from TI injury through attenuation of glial activation and maintenance of antioxidants, showing that 5-HT2A receptor is involved in RIS-induced hypothermia. Therefore, RIS could be introduced to reduce body temperature rapidly and might be applied to patients for hypothermic therapy following ischemic stroke.

show abstract

“…Typically, risperidone dosage in the elderly does not exceed 1–2 mg/d (Uchida & Mamo, 2009). Most reported cases of risperidone‐induced hypothermia refer to patients with higher dosages (up to 6–8 mg/d) (Nagamine, 2016; Perera & Yogaratnam, 2014; Zonnenberg et al., 2019). Hypothermia associated with pipamperone has been reported in numerous previous studies and case reports (Kamp, Paschali, & Lange‐Asschenfeldt, 2016; Kamp, Paschali, Supprian, et al., 2016; van Marum et al., 2007; Zonnenberg et al., 2017, 2019).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

Kamp

Paschali

Bouanane

et al. 2021

Human Psychopharmacology

View full text Add to dashboard Cite

Objective Hypothermia is a potentially lethal adverse reaction to typical and atypical antipsychotic drugs (APD). Among predisposing factors are advanced age and comorbid somatic diseases. The aim of this study was to assess the incidence of hypothermia and quantify risk factors. Method Charts of N = 3002 psychogeriatric inpatients were screened for incidence of hypothermia (body core temperature <35.0°C). The frequency of hypothermia was compared between patients treated with versus without APD and, within the sample of APD‐treated patients, for (1) specific APD, (2) sex, (3) main diagnosis, and (4) age. Results N = 54 cases (2.6%) of hypothermia occurred in APD‐treated patients and 12 cases (1.3%) in non‐APD‐treated patients (p = 0.024). In APD‐treated patients, only male sex (p = 0.038) and pipamperone were associated with a higher incidence of hypothermia (p = 0.0017). Whereas the main diagnosis delirium showed a trend to significance, age did not correlate with hypothermia. Conclusion Medication with pipamperone was associated with an increased risk of hypothermia. The advanced age of our sample might as well explain the high incidence of hypothermia within our sample and the failure to detect high age as a risk factor due to a ceiling effect.

show abstract

De Novo delayed onset hypothermia secondary to therapeutic doses of risperidone in bipolar affective disorder

Abstract: Here we report a case who has been treated for bipolar affective disorder for a considerable period of time with risperidone in a South Asian country, who went on to develop hypothermia which was reversed with the withdrawal of the offending

Cited by 13 publications

References 8 publications

Hypothermia in a patient with Alzheimer’s disease receiving a combination therapy with risperidone and pipamperone

Hypothermia in a patient with Alzheimer’s disease receiving a combination therapy with risperidone and pipamperone

Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress

Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

Contact Info

Product

Resources

About