I. Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice

Ruebush, Mary J.; Troutman, Eric H.; Kennedy, Debbie A.

doi:10.1016/0008-8749(86)90289-3

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…The importance of T cells for protective immunity against reinfection with B. microti has been suggested in earlier reports. For example, Ruebush et al (26) reported that a delayed-type hypersensitivity response occurs in parallel with resistance against B. microti. Transfer of immune spleen cells to recipient mice resulted in lower peak parasitemia after challenge infection than did transfer of normal spleen cells, and treatment with anti-theta serum abrogated the protective immunity of immune spleen cells (25).…”

Section: Discussionmentioning

confidence: 99%

Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Igarashi¹,

Suzuki

Waki

et al. 1999

Infect Immun

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Babesia microti produces a self-limiting infection in mice, and recovered mice are resistant to reinfection. In the present study, the role of T cells in protective immunity against challenge infection was examined. BALB/c mice which recovered from primary infection showed strong protective immunity against challenge infection. In contrast, nude mice which failed to control the primary infection and were cured with an antibabesial drug did not show protection against challenge infection. Treatment of immune mice with anti-CD4 monoclonal antibody (MAb) diminished the protective immunity against challenge infection, but treatment with anti-CD8 MAb had no effect on the protection. Transfer of CD4+ T-cell-depleted spleen cells resulted in higher parasitemia than transfer of CD8+ T-cell-depleted spleen cells. A high level of gamma interferon (IFN-γ), which was produced by CD4+ T cells, was observed for the culture supernatant of spleen cells from immune mice, and treatment of immune mice with anti-IFN-γ MAb partially reduced the protection. Moreover, no protection against challenge infection was found in IFN-γ-deficient mice. On the other hand, treatment of immune mice with MAbs against interleukin-2 (IL-2), IL-4, or tumor necrosis factor alpha did not affect protective immunity. These results suggest essential requirements for CD4+ T cells and IFN-γ in protective immunity against challenge infection with B. microti.

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Section: Discussionmentioning

confidence: 99%

Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Igarashi¹,

Suzuki

Waki

et al. 1999

Infect Immun

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“…microti antigens can trigger specific activation of T cells. Parasite-infected erythrocytes as well as free merozoites are able to sensitize mice for delayed-type hypersensitivity, an immune phenomenon mediated by T lymphocytes, in particular by the subpopulation known as CD4 ϩ Th1 cells (195). Mice depleted of CD4 ϩ T helper cells are more susceptible to B. microti infection than normal mice (91,205).…”

Section: Host Immune Responsementioning

confidence: 99%

Babesiosis

Homer¹,

Aguilar-Delfín²,

Telford³

et al. 2000

Clinical Microbiology Reviews

522

402

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II. Prostaglandin-mediated suppression of delayed-type hypersensitivity to infected erythrocytes during Babesia microti infection in mice

Ruebush¹,

Steel²,

Kennedy³

1986

Cellular Immunology

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I. Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice

Cited by 6 publications

References 17 publications

Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Babesiosis

II. Prostaglandin-mediated suppression of delayed-type hypersensitivity to infected erythrocytes during Babesia microti infection in mice

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I. Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice

Cited by 6 publications

References 17 publications

Roles of CD4+T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Roles of CD4+T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Babesiosis

II. Prostaglandin-mediated suppression of delayed-type hypersensitivity to infected erythrocytes during Babesia microti infection in mice

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Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice

Roles of CD4⁺T Cells and Gamma Interferon in Protective Immunity againstBabesia microtiInfection in Mice