<i>DGAT1</i> polymorphism in Riverine buffalo, Swamp buffalo and crossbred buffalo

Li, Jun; Liu, Shenhe; Li, Zipeng; Zhang, Shujun; Hua, Guohua; Salzano, Angela; Campanile, Giuseppe; Gasparrini, B.; Liang, Aixin; Yang, Liguo

doi:10.1017/s0022029918000468

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…The two SNPs g.8330T>C and g.9046T>C at exons 17 and 13 in DGAT1 gene were identified in Riverine, Swamp, and crossbred buffalo. Furthermore, it was revealed that g.9046T>C had been associated with the change in amino acid sequence at position 484 arginine to histidine (99). The SNP g.9046T>C was associated with fat percentage, and buffalo with TT genotype showed a higher association for milk fat percentage than the CC genotype.…”

Section: Dgat1 Role In Buffalo Milk Production Traitsmentioning

confidence: 99%

Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits

Khan

et al. 2021

Front. Vet. Sci.

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Milk fatty acids are essential for many dairy product productions, while intramuscular fat (IMF) is associated with the quality of meat. The triacylglycerols (TAGs) are the major components of IMF and milk fat. Therefore, understanding the polymorphisms and genes linked to fat synthesis is important for animal production. Identifying quantitative trait loci (QTLs) and genes associated with milk and meat production traits has been the objective of various mapping studies in the last decade. Consistently, the QTLs on chromosomes 14, 15, and 9 have been found to be associated with milk and meat production traits in cattle, goat, and buffalo and sheep, respectively. Diacylglycerol O-acyltransferase 1 (DGAT1) gene has been reported on chromosomes 14, 15, and 9 in cattle, goat, and buffalo and sheep, respectively. Being a key role in fat metabolism and TAG synthesis, the DGAT1 has obtained considerable attention especially in animal milk production. In addition to milk production, DGAT1 has also been a subject of interest in animal meat production. Several polymorphisms have been documented in DGAT1 in various animal species including cattle, buffalo, goat, and sheep for their association with milk production traits. In addition, the DGAT1 has also been studied for their role in meat production traits in cattle, sheep, and goat. However, very limited studies have been conducted in cattle for association of DGAT1 with meat production traits in cattle. Moreover, not a single study reported the association of DGAT1 with meat production traits in buffalo; thus, further studies are warranted to fulfill this huge gap. Keeping in view the important role of DGAT1 in animal production, the current review article was designed to highlight the major development and new insights on DGAT1 effect on milk and meat production traits in cattle, buffalo, sheep, and goat. Moreover, we have also highlighted the possible future contributions of DGAT1 for the studied species.

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Section: Dgat1 Role In Buffalo Milk Production Traitsmentioning

confidence: 99%

Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits

Khan

et al. 2021

Front. Vet. Sci.

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“…Marker-assisted selection is a useful approach to assist animal breeding. Recently, candidate genes harboring single nucleotide polymorphisms (SNP) significantly associated with milk fat content (Li et al, 2018c;Gu et al, 2019), protein percentage (Manzoor et al, 2018(Manzoor et al, , 2020, and fatty acid composition (Cosenza et al, 2017(Cosenza et al, , 2018 have been identified on different buffalo chromosomes. As for milk yield, one of the most important economic traits in buffalo industry, associated polymorphisms have been identified at the whole genome level (Wu et al, 2013;Venturini et al, 2014;de Camargo et al, 2015;Menon et al, 2016;El-Halawany et al, 2017;Iamartino et al, 2017;da Costa Barros et al, 2018;Du et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing

et al. 2020

Revista Brasileira De Zootecnia

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Breeding and genetics Full-length research article Identification of candidate genes associated with milk yield trait in buffaloes (Bubalus bubalis) by restriction-site-associated DNA sequencing ABSTRACT-The objectives of our present study included the screening of single nucleotide polymorphisms (SNP) that show significant differences in allelic frequencies between two buffalo populations (Egyptian and Chinese buffaloes), categorization of functional genes associated with these SNP by gene ontology, and pathway analyses to further understand their potential values as candidate genes closely associated with milk yield trait in buffaloes. In this study, double digest restrictionsite associated DNA sequencing was performed on Illumina HiSeq 2500 platform for 20 and 25 female buffaloes from Egypt and China, respectively. Approximately 118 Gb of sequencing data were obtained, and a total of 110,129 and 150,535 putative SNP were detected in Egyptian and Chinese buffaloes, respectively. Focused only on those SNP that differed significantly in allelic frequencies between the two populations, we found that genes associated with these SNP were significantly over-represented in the ionotropic glutamate receptor pathway, the endothelin signaling pathway, and the gonadotropin-releasing hormone receptor pathway, which contained a total of 29 genes. Of these, nine genes (ADCY5, CACNA1A, CREB1, INHBA, INHBB, PIK3R1, PLCB1, PRKCE, and SMAD2) participating in the hormonal regulation of lactation, were considered to be promising candidate genes worthy of further investigations for favorable alleles associated with milk yield. Our results provide useful information about genetic variations in Egyptian and Chinese buffaloes. The potential influences of nine candidate genes and their associated SNP on milk yield need to be validated in more buffalo populations.

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“…The association between udder traits and milk production performance has been broadly corroborated, and many GWAS reported candidate genes may influence mammary development (Flury, 2014; Pausch et al ., 2016). However, most of these genes have a limited role in milk productive traits through effects on mammary growth, and many genes associated with milk productive traits were not found to be associated with udder traits, such as DGAT1 (Li et al ., 2018), PRL (Li et al ., 2017), and ABCG2 (Cohen-Zinder et al ., 2005). In the present study, none of candidate genes except ACTC1 have obvious effects on milk production.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study for buffalo mammary gland morphology

Liu

et al. 2020

Journal of Dairy Research

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This research communication describes a genome-wide association study for Italian buffalo mammary gland morphology. Three single nucleotide polymorphisms (AX-85117983, AX-8509475 and AX-85117518) were identified to be significantly associated with buffalo anterior teat length, posterior teat length and distance between anterior and posterior teat, respectively. Two significant signals for buffalo mammary gland morphology were observed in two genomic regions on the chromosome 10, and chromosome 20. One of the regions located on the chromosome 10 has the most likely candidate genes ACTC1 and GJD2, both of which have putative roles in the regulation of mammary gland development. This study provides new insights into the genetic variants of buffalo mammary gland morphology and may be beneficial for understanding of the genetic regulation of mammary growth.

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DGAT1 polymorphism in Riverine buffalo, Swamp buffalo and crossbred buffalo

Cited by 10 publications

References 9 publications

Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits

Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits

Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing

Genome-wide association study for buffalo mammary gland morphology

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