2009
DOI: 10.1091/mbc.e08-09-0899
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DictyosteliumDock180-related RacGEFs Regulate the Actin Cytoskeleton during Cell Motility

Abstract: Cell motility of amoeboid cells is mediated by localized F-actin polymerization that drives the extension of membrane protrusions to promote forward movements. We show that deletion of either of two members of the Dictyostelium Dock180 family of RacGEFs, DockA and DockD, causes decreased speed of chemotaxing cells. The phenotype is enhanced in the double mutant and expression of DockA or DockD complements the reduced speed of randomly moving DockD null cells' phenotype, suggesting that DockA and DockD are like… Show more

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Cited by 23 publications
(34 citation statements)
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“…The lack of developmental changes following ZizA loss does not preclude an important role for the protein in development because the cellular roles for the protein might be, at least partially, compensated for by the other zizimin proteins. This functional redundancy has been shown in other small GTPase-related signalling families of D. discoideum Doc proteins (Para et al, 2009), RacB and Rac GEF1 (Park et al, 2004) and Trix Rac GEF (Strehle et al, 2006). However, ablation of ZizB did perturb development, suggesting a crucial role that cannot be replaced by related proteins, or that the relatively low expression levels of ZizA, ZizC and ZizD cannot effectively complement loss of ZizB.…”
Section: Discussionmentioning
confidence: 64%
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“…The lack of developmental changes following ZizA loss does not preclude an important role for the protein in development because the cellular roles for the protein might be, at least partially, compensated for by the other zizimin proteins. This functional redundancy has been shown in other small GTPase-related signalling families of D. discoideum Doc proteins (Para et al, 2009), RacB and Rac GEF1 (Park et al, 2004) and Trix Rac GEF (Strehle et al, 2006). However, ablation of ZizB did perturb development, suggesting a crucial role that cannot be replaced by related proteins, or that the relatively low expression levels of ZizA, ZizC and ZizD cannot effectively complement loss of ZizB.…”
Section: Discussionmentioning
confidence: 64%
“…The D. discoideum Dock180-related proteins, DocA and DocD regulate the actin cytoskeleton and cell motility (Para et al, 2009). In our study, we explore the role of the highest expressing D. discoideum zizimins, ZizA and ZizB and show both novel and conserved functions of these members of the ancient zizimin protein family.…”
Section: Introductionmentioning
confidence: 91%
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