<i>Doenjang</i>, a Fermented Soybean Paste, Decreased Visceral Fat Accumulation and Adipocyte Size in Rats Fed with High Fat Diet More Effectively Than Nonfermented Soybeans

Kwak, Chung Shil; Park, Sang Chul; Song, Kye Yong

doi:10.1089/jmf.2010.1224

Cited by 64 publications

(60 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No difference in these parameters was detected between the M-HF, BSM-HF, and HF groups. Our data are consistent with the findings of a previous study showing that steamed soybeans and doenjang (steamed soybeans fermented and aged for 10 months) suppressed body weight gain and elevation of hepatic triglyceride and cholesterol levels in Sprague-Dawley rats fed a high-fat (30%) diet for 8 weeks [46].…”

Section: Am Effects On the Levels Of Serum Total Cholesterol And Fecasupporting

confidence: 93%

Fermented Miso with Adzuki Beans or Black Soybeans Decreases Lipid Peroxidation and Serum Cholesterol in Mice fed a High-Fat Diet

Wu¹,

Feng²,

Ci³

et al. 2015

JFNR

View full text Add to dashboard Cite

The seed coat extracts of adzuki beans and black soybeans have high antioxidant properties, suggesting health-promoting effects. However, there are few data on the activity of fermented adzuki beans or black soybeans in vivo. This study examined the effects of adzuki beans and black soybeans in mice fed a high-fat diet. Adzuki beans and black soybeans were fermented with soybeans and rice koji for 6 months (miso) and compared with similarly fermented soybeans. Adzuki beans and black soybeans demonstrated higher antioxidant activity compared to soybeans, as evidenced by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. In the in vivo experiments, mice were fed for 5 weeks with a high-fat diet supplemented or not with 10% adzuki bean miso, 10% black soybean miso, or 10% soybean miso. Dietary supplementation with adzuki beans and black soybeans significantly decreased serum aspartate transaminase (58.6% and 62.6%, respectively) and lipid peroxidation in the liver (42.8% and 40.8%, respectively) compared to the soybean control group. Furthermore, mice receiving adzuki beans demonstrated a significant decrease in serum cholesterol (31.0%) and increase in fecal bile acid content (40.0%) compared to the soybean-fed mice. These results indicate that dietary supplementation with adzuki beans and black soybeans characterized with high antioxidant activity may exert health beneficiary effects such as liver protection and reduction of total cholesterol.

show abstract

Section: Am Effects On the Levels Of Serum Total Cholesterol And Fecasupporting

confidence: 93%

Fermented Miso with Adzuki Beans or Black Soybeans Decreases Lipid Peroxidation and Serum Cholesterol in Mice fed a High-Fat Diet

Wu¹,

Feng²,

Ci³

et al. 2015

JFNR

View full text Add to dashboard Cite

show abstract

“…34 Recently, antiobesity effects of doenjang have been observed in animals, 35,36 which may have been due to constituents such as genistein activating the transcription of carnitine palmitoyltransferase-I, a rate regulating enzyme for fatty acid oxidation, and peroxisome proliferator-activated receptor-alpha target genes involved in fatty acid beta oxidation. 25,34,35 However, doenjang is a unique soybean paste fermented by diverse microorganisms, which uses Bacillus subtilis and B. licheniformis and molds such as Rhizopus, Mucor, and Aspergillus oryzae from rice straw and local environments instead of inoculation. 37,38 Recently, 16S rRNA cloning and sequencing, PCR-DGGE, and 454 pyrosequencing were used to analyze the bacterial community of finally fermented doenjang and revealed that its dominant microbes are Staphylococcus equorum, Enterococcus faecium, Tetragenococcus halophilus, Leuconostoc mesenteroides, and Staphylococcus gallinarum.…”

Section: Discussionmentioning

confidence: 99%

“…20 Recently, doenjang research has focused on its excellent nutritional value as well as its health-promoting properties, such as its antioxidant, 21 fibrinolytic, 22 antimutagenic, 23 anticancer, 24 and antiobesity effects. 25 However, its effect on gut microbiota, particularly endotoxins, has not been studied.…”

Section: Introduction Hmentioning

confidence: 99%

Doenjang, a Fermented Korean Soybean Paste, Inhibits Lipopolysaccharide Production of Gut Microbiota in Mice

Jang

Kim

Han

et al. 2014

Journal of Medicinal Food

View full text Add to dashboard Cite

Doenjang has been reported to exhibit antioxidant, fibrinolytic, antimutagenic, anticancer, and antiobesity effects. In our preliminary study, doenjang decreased fecal lipopolysaccharide (LPS) levels in mice. Therefore, we investigated the effect of doenjang on the composition of gut microbiota in mice. Treatment with doenjang significantly increased the number of bifidobacteria cultured in BL media, compared with mice not treated with doenjang. However, doenjang decreased the number of Enterobacteriaceae cultured in DHL media. Doenjang significantly suppressed the b-glucuronidase activity, but did not influence a-/b-glucosaminidase and a-/b-glucosidase activities. When gut microbiota in mice treated with or without doenjang was analyzed by pyrosequencing, doenjang induced a significant modulation of the populations of the dominant gut microbiota. At the phylum level, doenjang treatment resulted in a significant decrease of Firmicutes and an increase of Bacteroidetes, which led to a decrease in the Firmicutes to Bacteroidetes ratio in gut microbiota. At the family level, the number of Ruminococcaceae and Lachnospiraceae were significantly decreased, while the number of Odoribacter_f was increased in doenjang-treated mice. Of colonic tight junction proteins, occludin, ZO-1, and claudin-1 in mice, occludin alone was significantly increased by treatment with doenjang. Although treatment with doenjang seemed to suppress NF-jB activation, it was not significant. Doenjang significantly suppressed tumor necrosis factor-a expression, whereas it did not influence interleukin (IL)-1b and IL-6 expression. However, doenjang increased IL-10 expression. Based on these findings, doenjang may promote gut health by regulating gut microbiota and its LPS concentrations and suppressing harmful enzyme production.

show abstract

“…Study shows that when viscous dietary fiber is ingested, the expression of CPT-1B in the muscle increased significantly along with improvement in the level of stored fat [11]. Also, in another report, it was found that the stored fat level and TG concentration level decreased at the same time while the expression of CPT-1 increased following an 8 week of high-fat diet combined with fermented soybean paste [18]. These study results are similar to the results with FABP in our study.…”

Section: Discussionmentioning

confidence: 86%

Glasswort Powder Diet Activates Lipid Metabolism in Rat

Seo¹,

Kwak²,

Nam³

et al. 2012

Journal of Life Science

View full text Add to dashboard Cite

The purpose of this study was to investigate the effects of glasswort powder intake on lipid metabolism. Rats were divided into three groups: a group fed a normal diet (CON), one fed a high fat diet (HFC), and one fed a high fat diet with glasswort powder (HFG). They were fed their respective diet for four weeks. Body weight was significantly lower (9%) in the HFG group than in the HFC group at the fourth week. According to the feces analysis, the HFG group showed the highest fat level (120% vs. CON; 138% vs. HFC) and fecal calories (110%). The concentration level of TG and LDL-C was 71.8% lower in the HFG group compared to the HFC group, while the concentration level of HDL-C was 152% higher in the HFG group. Expression of FABP in the liver was 197% greater in the HFG compared to the HFC group, with the expression of CPT-1 showing a similar tendency. These results suggest that glasswort powder intake suppresses weight gain and improves fat metabolism at the level of liver cells. From these results, we suggest that glasswort powder is effective against obesity by inhibiting the absorption of fat in the digestive tract.

show abstract

Doenjang, a Fermented Soybean Paste, Decreased Visceral Fat Accumulation and Adipocyte Size in Rats Fed with High Fat Diet More Effectively Than Nonfermented Soybeans

Cited by 64 publications

References 34 publications

Fermented Miso with Adzuki Beans or Black Soybeans Decreases Lipid Peroxidation and Serum Cholesterol in Mice fed a High-Fat Diet

Fermented Miso with Adzuki Beans or Black Soybeans Decreases Lipid Peroxidation and Serum Cholesterol in Mice fed a High-Fat Diet

Doenjang, a Fermented Korean Soybean Paste, Inhibits Lipopolysaccharide Production of Gut Microbiota in Mice

Glasswort Powder Diet Activates Lipid Metabolism in Rat

Contact Info

Product

Resources

About