<i>Dolomiaea costus:</i>
            an untapped mine of sesquiterpene lactones with wide magnificent biological activities

Abouelwafa, Ebraheem; Abotalib, Abotalib Z.; Sabry, Omar M.; Caprioli, Giovanni; Abdel-Sattar, Essam

doi:10.1080/14786419.2022.2164577

Cited by 5 publications

(1 citation statement)

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“…The genus Saussurea DC is well known for its rich chemical composition and wide range of biological activity, and therefore it is necessary to resolve issues related to the conservation of the biological diversity of species of the genus Saussurea, which require a preliminary in-depth study of the composition, morphology and geography of the species [6]. At the moment, the scope and boundaries of the genus, as well as the family relationships between its constituent substances and pharmacological activities remain as the subject of debate and continue to be revised [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

FT-IR Analysis and Acute Toxicity of the Extracts of Wild-Growing Saussurea sordida, Saussurea alpina Native to Kazakhstan

Orynbassarova,

Karzhaubayeva,

Ordabayeva

et al. 2024

Preprint

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Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. The objects of the study are medicinal plant raw materials Saussurea sordida Kar&Kir and Saussurea alpina DC. collected from South Kazakhstan during the flowering period in the spring-summer months of 2021. The present study was aimed to investigate the toxic effects acute administration of ethanol extracts from plants S. sordida and S. alpina in male Wistar rats. The ethanol extract by subjected to Phytochemical Screening, Fourier transform infrared spec-troscopy (FTIR) analysis. Phytochemical screening of the extract revealed the presence of phenolic compounds. FT-IR spectroscopic analysis revealed various characteristic band values with various functional groups in the formulation extract such as amines, alcohol, phenol, alkane, alkene, and conjugated acid groups. FT-IR analysis of peak values with various functional compounds such as alcohols, phenols, carboxylic acids, aldehydes, amides, amino acids, anhydrides, esters, ketones, unsaturated aliphatic, aromatics, unsaturated heterocycles, amines, nitro compound, alkanes, al-kenes and sugars. Histological examination of organ samples after studying the chronic toxicity of ex-tracts of two plant species (S. sordida . and S. alpina) revealed no pathological changes. The acute toxicity study revealed no lethal effects and behavioral signs of toxicity at the tested doses indicating that LD50 is greater than 2000 mg/kg. These results show low toxicity of on short-term use and liver toxicity on long-term use. This study helps to predict the formula and structure of active molecules which can be used as medicinal drugs. This result also enhances the traditional usage of S. sordida and S. alpina , which possesses a number of bioactive compounds.

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