<i>Drosophila</i>
            as a Tool for Drug Discovery

Li, Hao; Garza, Dan

doi:10.1002/0470014067.ch4

Model Organisms in Drug Discovery 2003

DOI: 10.1002/0470014067.ch4

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Drosophila as a Tool for Drug Discovery

Hao Li

Dan Garza

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Cited by 2 publications

References 86 publications

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Functional genomics to new drug targets

Kramer

Cohen

2004

Nat Rev Drug Discov

160

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The completion of the sequencing of the human genome, and those of other organisms, is expected to lead to many potential new drug targets in various diseases, and it is predicted that novel therapeutic agents will be developed against such targets. The role of functional genomics in modern drug discovery is to prioritize these targets and to translate that knowledge into rational and reliable drug discovery. Here, we describe the field of functional genomics and review approaches that have been applied to drug discovery, including RNA profiling, proteomics, antisense and RNA interference, model organisms and high-throughput, genome-wide overexpression or knockdowns, and outline the future directions that are likely to yield new drug targets from genomics.

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Functional genomics to new drug targets

Kramer

Cohen

2004

Nat Rev Drug Discov

160

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Unit Operations of Tissue Development: Epithelial Folding

Zartman

Shvartsman

2010

Annu. Rev. Chem. Biomol. Eng.

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The development of multicellular organisms relies on a small set of construction techniques—assembly, sculpting, and folding—that are spatially and temporally regulated in a combinatorial manner to produce the diversity of tissues within the body. These basic processes are well conserved across tissue types and species at the level of both genes and mechanisms. Here we review the signaling, patterning, and biomechanical transformations that occur in two well-studied model systems of epithelial folding to illustrate both the complexity and modularity of tissue development. In particular, we discuss the possibility of a spatial code specifying morphogenesis. To decipher this code, engineers and scientists need to establish quantitative experimental systems and to develop models that address mechanisms at multiple levels of organization, from gene sequence to tissue biomechanics. In turn, quantitative models of embryogenesis can inspire novel methods for creating synthetic organs and treating degenerative tissue diseases.

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Drosophila as a Tool for Drug Discovery

Cited by 2 publications

References 86 publications

Functional genomics to new drug targets

Functional genomics to new drug targets

Unit Operations of Tissue Development: Epithelial Folding

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