Abstract:Phosphatidylinositol (PI) 4,5-bisphosphate (PI(4,5)P2 or PIP2) is involved in many biological functions. However, the mechanisms of PIP2 in collective cell migration remains elusive. This study highlights the regulatory role of cytidine triphosphate synthase (CTPsyn) in collective border cell migration through regulating the asymmetrical distribution of PIP2. We demonstrated that border cell clusters containing mutant CTPsyn cells suppressed migration. CTPsyn was co-enriched with actin at the leading edge of t… Show more
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