2017
DOI: 10.1073/pnas.1610614114
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Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation

Abstract: Paired box 6 (Pax6) is considered to be the master control gene for eye development in all seeing animals studied so far. In vertebrates, it is required not only for lens/retina formation but also for the development of the CNS, olfactory system, and pancreas. Although Pax6 plays important roles in cell differentiation, proliferation, and patterning during the development of these systems, the underlying mechanism remains poorly understood. In the fruit fly, Drosophila melanogaster, Pax6 also functions in a ra… Show more

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Cited by 44 publications
(65 citation statements)
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“…Interestingly, 90% of the ey-GAL4>dTgs1-RNAi>Smn-RNAi late lethal pupae manually extracted from the puparium showed a failure in development of the head structures ( Figure 5E). Headless flies have been previously observed in mutants in genes that initiate eye specification such as the two fly Pax6 genes ey and toy (Jiao et al, 2001;Zhu et al, 2017). Collectively, these results indicate that dTgs1 and Smn cooperate in the pathways involved in eye and head development.…”
Section: Functional Interactions Between Dtgs1 and Smn In Drosophila supporting
confidence: 54%
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“…Interestingly, 90% of the ey-GAL4>dTgs1-RNAi>Smn-RNAi late lethal pupae manually extracted from the puparium showed a failure in development of the head structures ( Figure 5E). Headless flies have been previously observed in mutants in genes that initiate eye specification such as the two fly Pax6 genes ey and toy (Jiao et al, 2001;Zhu et al, 2017). Collectively, these results indicate that dTgs1 and Smn cooperate in the pathways involved in eye and head development.…”
Section: Functional Interactions Between Dtgs1 and Smn In Drosophila supporting
confidence: 54%
“…To ascertain a possible role of dTgs1 in the eye development we exploited the dTgs1-RNAi construct and the eyeless-Gal4 driver (ey-Gal4), which efficiently drives expression of UAS-RNAi constructs in the eye imaginal disc (Fan et al, 2014). eyeless is an essential Drosophila Pax6 gene that specifically promotes growth of the eye imaginal disc and it is required for eye progenitor cell survival and proliferation (Callaerts et al, 2001;Zhu et al, 2017).…”
Section: The Roles Of Dtgs1 and Smn In Eye Developmentmentioning
confidence: 99%
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“…Until recently, it has been assumed that the RD network is primarily tasked with promoting an eye fate. Indeed, several network members are known to participate in retinal cell proliferation, pattern formation, and cell‐fate specification (Pignoni et al, ; Suzuki and Saigo, ; Yan et al, ; Pauli et al, ; Zhang et al, ; Jemc and Rebay, ; Tanaka‐Matakatsu and Du, ; Li et al, ; Weasner and Kumar, ; Karandikar et al, ; Tanaka‐Matakatsu et al, ; Zhu et al, ).…”
Section: Tissue Fate Specification: When the Best Offense Is A Good Dmentioning
confidence: 99%
“…One thing that is clear from the papers that follow is that the impact of thinking on gene networks in bioscience is truly broad and deep. The topics span a wide range, from the differentiation of germ cells (1), immunology (2,3), and the molecular basis of celltype differentiation (4)(5)(6)(7)(8)(9)(10)(11), to paleontology (12,13) and behavior (14). The central role of network thinking is revealed in the way it allows for both the design of testable experimental frameworks to probe complex biological processes and the conceptual framework for understanding biological mechanisms.…”
mentioning
confidence: 99%