<i>Drosophila melanogaster</i>, a new model for exercise research

Riddle, Nicole C.

doi:10.1111/apha.13352

Cited by 12 publications

(14 citation statements)

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“…To understand the impact of these factors and interactions between them, it is necessary to test many individuals in a large number of conditions, something non-mammalian model systems are ideally suited to. In C. elegans, swim training is used to exercise animals [17,18], and in D. melanogaster, several different exercise systems exist that all exploit the animals' natural geotaxis behavior, their tendency to move to the top of an enclosure [19][20][21][22]. In both model systems, genetic tools exist to efficiently screen large numbers of target genes through, for example, RNAi knockdown collections, or to identify genes linked to exercise phenotypes using mapping populations.…”

Section: Public Health Entities Including the World Health Organization And The Us Centers For Diseasementioning

confidence: 99%

Exercise-induced changes in climbing performance

Watanabe

Riddle

2021

Preprint

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Exercise is recommended to promote health and prevent a range of diseases. However, how exercise precipitates these benefits is unclear, nor do we understand why exercise responses differ so widely between individuals. We investigate how climbing ability in Drosophila melanogaster changes in response to an exercise treatment. We find extensive variation in baseline climbing ability, and exercise-induced changes ranging from -13% to +20% in climbing ability. Climbing ability, and its exercise-induced change, are sex- and genotype-dependent. GWASs implicate "cell-cell signaling" genes in the control of climbing ability. We also find that animal activity does not predict climbing ability and that the exercise-induced climbing ability change cannot be predicted from the activity level induced by the exercise treatment. These results provide promising new avenues for further research into the molecular pathways controlling climbing activity and illustrate the complexities involved in trying to predict individual responses to exercise.

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Section: Public Health Entities Including the World Health Organization And The Us Centers For Diseasementioning

confidence: 99%

Exercise-induced changes in climbing performance

Watanabe

Riddle

2021

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“…Model organisms such as Drosophila melanogaster and Caenorhabditis elegans provide a unique opportunity to further our understanding of the genetic factors controlling body weight, body size, as well as the impact of exercise on weight and other aspects of physiology (Laranjeiro et al, 2017;Riddle, 2019;Sujkowski & Wessells, 2018;Watanabe & Riddle, 2019).…”

Section: Introductionmentioning

confidence: 99%

GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise

Watanabe

Riddle

2020

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Body size and weight show considerable variation both within and between species. This variation is controlled in part by genetics, but also strongly influenced by environmental factors including diet and the level of activity experienced by the individual. Due to the increasing obesity epidemic in much of the world, there is considerable interest in the genetic factors that control body weight and how weight changes in response to exercise treatments. Here, we use GWAS in Drosophila to identify the molecular pathways that control weight and exercise-induced weight changes. We find that there is a complex set of molecular pathways controlling weight, with many genes linked to the central nervous system (CNS). Weight was strongly impacted by animal size and body composition. While the CNS appears to be important for weight and exercise-induced weight change, signaling pathways are particularly important for determining how exercise impacts weight.

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“…Even Drosophila melanogaster was recruited as a new model for exercise research in order to enable large scale studies with broad sets of parameters. 4 Physical exercise can counteract many cancer promoting factors, such as high inflammatory levels, high levels of adipose tissue, cachexia, cardiovascular diseases 5 and a low mitochondrial capacity. Therefore, researchers are more and more eager to understand the molecular mechanisms that promote the manifold of effects that exercise can have on our physiology.…”

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confidence: 99%

“…Exercise training was brought into focus lately as a toxin‐free addition to promote a positive outcome of cancer treatments (surgery, chemo‐, radiation‐, hormonal therapy). Even Drosophila melanogaster was recruited as a new model for exercise research in order to enable large scale studies with broad sets of parameters 4 . Physical exercise can counteract many cancer promoting factors, such as high inflammatory levels, high levels of adipose tissue, cachexia, cardiovascular diseases 5 and a low mitochondrial capacity.…”

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confidence: 99%

Physical exercise—A toxin‐free complement to cancer therapy

Groeneveld

2021

Acta Physiologica

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Drosophila melanogaster, a new model for exercise research

Cited by 12 publications

References 10 publications

Exercise-induced changes in climbing performance

Exercise-induced changes in climbing performance

GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise

Physical exercise—A toxin‐free complement to cancer therapy

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