(E)-3-(2,6-Dichlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

Abstract

In the title compound, C16H12Cl2O2, the dichloro­phenyl and methoxy­phenyl groups are linked by a prop-2-en-1-one group. The C=C double bond is trans configured. The mol­ecule is not planar, as can be seen from the dihedral angle of 6.21 (7)° between the planes of the two rings. The crystal structure can be described by two types of crossed layers which are parallel to (110) and (10).

(2E)-1-(5-Chlorothiophen-2-yl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one

“…For general background to chalcones and their biological properties, see: Choudary et al (1999); Tomazela et al (2000). For a related structure, see: Benmekhbi et al (2009). Table 1 Hydrogen-bond geometry (Å , ).…”

“…The other methoxy group at O2 is in a + synclinal conformation as indicated by the torsion angle 73.6 (2)° for C14-O2-C13-C12. The C═C double bond exhibits an E conformation (Benmekhbi, et al, 2009). The crystal structure is stabilized by two different C-H•••O intermolecular interactions generating chains of molecules along the b-axis (Fig.…”

Synthesis of novel triazoloquinoxaline‐pyrazole hybrids as antiproliferatives, EGFR inhibitors, and apoptosis inducers

“…Compounds 4‐(phenyldiazenyl)‐1 H ‐pyrazole‐3,5‐diamine derivatives, [17] 2‐cyanoacetohydrazide, [18] 1,3‐diphenyl‐1 H ‐pyrazole‐5‐carbaldehydes, [19] ethoxymethylenemalononitrile, [17,20] bis (methylthio)‐methy‐lenemalononitrile, [21] 2‐(phenyldiazenyl)malononitrileanalogues, [22,23] and 3‐(2,4‐dichlorophenyl)‐1‐(aryl)prop‐2‐en‐1‐one derivatives [24,25] were prepared according to the reported procedures.…”

“…Anticancer research was conducted on local strain found in the Regional Center for Genetic Engineering, Faculty of Science (Boys), University of Al-Azhar, and the findings were within ±0.4% of the measured outcome. Compounds 4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine derivatives, [17] 2-cyanoacetohydrazide, [18] 1,3-diphenyl-1Hpyrazole-5-carbaldehydes, [19] ethoxymethylenemalononitrile, [17,20] bis(methylthio)-methy-lenemalononitrile, [21] 2-(phenyldiazenyl)malononitrileanalogues, [22,23] and 3-(2,4dichlorophenyl)-1-(aryl)prop-2-en-1-one derivatives [24,25] were prepared according to the reported procedures. were heated under reflux in dioxane/DMF mixture (10/5 mL), containing few drops of TEA for 13 hours.…”

(2E)-1-(5-Chlorothiophen-2-yl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one

“…For general background to chalcones, see: Tomazela et al (2000); Uchida et al (1998); Zyss & Chemla (1987). For related structures, see: Benmekhbi et al (2009). Table 1 Hydrogen-bond geometry (Å , ).…”