In this paper, one of the selective and potent inhibitors named (E)-3-benzylidene-indoline-2-one (I), as against different receptor tyrosine kinase in metastasis, angiogenesis, and tumor growth, is inspected in the gas phase and in solution, at B3LYP/6-311++G** and B3LYP/AUG-cc-pVTZ level of theory. A