<i>eCAM</i>: Clinical Analyses and Increasing Visibility

Cooper, Edwin L.

doi:10.1093/ecam/nep008

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…While the dietary botanical supplement market is growing, the need for more rigorous clinical and scientific research on herbal and traditional medicine is strongly advocated for larger acceptances and visibility [ 1 ]. Traditional herbal medicines have a long history of use and are generally considered to be safer than synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction

Puranik

Halade

Kumar

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.

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Section: Introductionmentioning

confidence: 99%