<i>Effects of halothane and sevoflurane on QT dispersion in paediatric patients</i>

Gürkan, Yavuz; Canatay, Hakan; Ağaçdiken, Ayşen; Ural, Ertan; Toker, Kamil

doi:10.1046/j.1460-9592.2003.01041.x

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…Therefore, it is most important to determine the effect of lidocaine on the detrimental effects of TI and anaesthetic agents on cardiac functions. The only trial evaluating the effects of TI on QTcd under sevoflurane anaesthesia was performed by Gurkan, et al 28) Similarly, in the present study the QTcd was also unchanged. One distinctive feature between the 2 studies is that they conducted their trial in paediatric patients.…”

Section: )supporting

confidence: 68%

“…Although the present study did not aim to evaluate the effects of sevoflurane in different types of surgery, it has been demonstrated that sevoflurane anaesthesia increased the QTc interval in laparotomic gynaecological surgery 26) but had no effect on the main haemodynamics during minor gynaecological surgeries. 27) Moreover, some have suggested that QTd and the QTcd are not affected 28) regardless of the severity and type of surgery. On the other hand, there are reports showing that all QT parameters (QT, QTc, QTd, and QTcd) 3) or 2 parameters such as QT and QTc 29) or QTd and QTcd 3) increased.…”

Section: )mentioning

confidence: 99%

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Effects of Intravenous Lidocaine on QTd and HRV Changes Due to Tracheal Intubation During Sevoflurane Induction

et al. 2006

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SUMMARYThe aim of the present study was to evaluate the effects of IV lidocaine on autonomic cardiac function changes in tracheal intubation (TI) during sevoflurane anaesthesia by using more reliable parameters, namely, the analysis of QT dispersion and heart rate variability (HRV) from Holter monitoring. In this prospective, double-blind study, 44 American Society of Anaesthesiologists class I-II patients scheduled for hysterectomy were randomly and equally divided into 2 groups; a control sevoflurane group (group S, n = 22) and a lidocaine sevoflurane group (group LS, n = 22).Before the induction of anaesthesia, the electrocardiograms (ECG) of all patients were recorded for 3 minutes as baseline parameters. In both groups, the anaesthesia was induced with 7% sevoflurane in O 2 at 6L min -1 via a facemask for 2 minutes. However, before the induction of sevoflurane anaesthesia in group LS, 1 mg kg -1 of lidocaine was given intravenously (IV). For muscle relaxation during TI, vecuronium was given to all participants. Three minutes after administration of vecuronium, TI was performed and an ECG was recorded synchronously for another 3 minutes. The results from the later records were used as postintubation parameters.Baseline and postintubation data were analysed. When compared to baseline values, postintubation LF/HF and SDNN values were increased in group S (P = 0.005, P = 0.001, respectively), whereas postintubation LF and HF values were decreased in group LS (P = 0.014, P = 0.041, respectively). Under the influence of sevoflurane anaesthesia, TI resulted in sympathetic activation. However, this activation was attenuated by the administration of IV 1 mg kg -1 lidocaine 5 minutes prior to TI. (Int Heart J 2006; 47: 597-606)

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Section: )supporting

confidence: 68%

Section: )mentioning

confidence: 99%

Effects of Intravenous Lidocaine on QTd and HRV Changes Due to Tracheal Intubation During Sevoflurane Induction

et al. 2006

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“…Comparing the basal values of QT and QTc intervals of patients before induction with the measurements after 20 minutes of induction, no arrhythmia was observed to have developed in the patients, and the QTc interval did not exceed 440 milliseconds; however, it was suggested that sevoflurane significantly prolonged the QTc interval [12]. On the other hand, Gurkan et al reported that halothane and sevoflurane used for induction in pediatric patients caused various levels of abnormalities in ventricular repolarization following tracheal intubation, and that a greater increase of the QTd and QTcd values was observed in halothane following the intubation [13].…”

Section: Discussionmentioning

confidence: 95%

Comparison of the effect of sevoflurane and desflurane on postoperative arrhythmia and QT dispersion

Gözdemir¹,

Yeter²,

Akçay³

et al. 2010

Open Medicine

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AbstractThe aim of this study was to investigate the effect of sevoflurane and desflurane on cardiac arrhythmias in adult patients who will be anesthetized. A total of 40 patients who were in the ASA I–II group and who were to undergo elective surgery were included in the study. No pre-medication was administered to the patients. They were monitored with the Holter equipment at preoperative 24 hours, and also at postoperative 24 hours on condition that Holter monitoring will begin before induction. Following routine monitoring, the patients were randomly divided into two equal groups; group one was given sevoflurane and group two was given desflurane. In this study, desflurane and sevoflurane resulted in both a significant prolongation of QT and QTc and a significant increase in QT and QTc dispersion when compared with the basal values. In the sevoflurane group, there was no significant increase in postoperative ventricular arrhythmia, compared to that during the preoperative period. However, this increase was significant in the desflurane group (p = 0.009). Sevoflurane and desflurane result in an increase in QT dispersion. Postoperative rhythmic control should carefully be monitored, especially in the desflurane group.

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“…7,16,17 Acquired QT prolongation and increased dispersion have been found to be associated with an increase in sudden cardiac death as in long QT syndrome. [17][18][19] Tavernier et al found out that patients with ventricular fibrillation without underlying structural heart disease had abnormal repolarization behavior, characterized by an increased QTD. 18 Reversal of the increase in QTD by antiarrhythmic agents in patients with the long QT syndrome or dilated cardiomyopathy indicates that this parameter can be used as an efficacy measure in the treatment of serious arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Surgery: Does It Increase the Probability of Atrial and Ventricular Arrhythmias in Children?

Çiftçi

Elemen

et al. 2008

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Effects of halothane and sevoflurane on QT dispersion in paediatric patients

Abstract: Neither sevoflurane nor halothane caused a significant increase in QTd compared with control values before induction. Only QTd following intubation was significantly greater in the halothane group than the sevoflurane group.

Cited by 23 publications

References 21 publications

Effects of Intravenous Lidocaine on QTd and HRV Changes Due to Tracheal Intubation During Sevoflurane Induction

Effects of Intravenous Lidocaine on QTd and HRV Changes Due to Tracheal Intubation During Sevoflurane Induction

Comparison of the effect of sevoflurane and desflurane on postoperative arrhythmia and QT dispersion

Laparoscopic Surgery: Does It Increase the Probability of Atrial and Ventricular Arrhythmias in Children?

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