Eikenella corrodens infections in human: Reports of six cases and review of literatures

Abstract

Purpose To investigate clinical characteristics of six cases of Eikenella corrodens infection in Ningbo First Hospital in China in recent 2 years. Methods We retrospectively analyze medical records of six cases of E. corrodens infection in Ningbo First Hospital from 2020 to 2021. And we describe the gender, age, clinical manifestations, antimicrobial administration, and treatment of the six patients. Results Five of the patients had deep infection and they were treated with surgical drainage or abscess resection plus antimicrobial administration. After treatment, five patients were discharged and recovered well, and another patient was transferred to another hospital for further treatment. All the six cases were in line with the reports on the clinical characteristics of patients infected with E. corrodens at home and abroad before 2021. Conclusion Eikenella corrodens is a part of the normal flora of human oropharynx, but it can migrate to other parts of the human body to cause severe invasive disease in humans. Although it is susceptible to most antimicrobials, it needs debridement in the treatment of deep infection.

Oral microbiota study of the patients after hospitalisation for COVID-19, considering selected dental indices and antibiotic therapy using the next generation sequencing method (NGS)

“…In this study, the Eikenella genus was present in a significantly higher percentage in group I (saliva, supragingival plaque) and in group II, as compared to group III (saliva, tongue). Scientific reports indicate participation of Eikenella in deltoid muscle abscess, pericarditis, brain abscess, perirenal abscess, head and neck infections, liver abscess, and hip arthritis [ 40 ].…”

Eikenella corrodens brain abscess after frontal sinusitis in immunocompetent patient

“…Eikenella corrodens es un bacilo gramnegativo anaerobio facultativo, perteneciente a la familia Neisseriaceae , que forma parte de la microbiota normal de la cavidad oral, las vías respiratorias altas y la mucosa intestinal humana [ 1 ]. Raramente actúa como patógeno y sus infecciones suelen ser localizadas, aunque se han descrito casos invasivos en pacientes inmunodeprimidos o con otros factores de riesgo como manipulación quirúrgica de las vías aéreas, alcoholismo, drogadicción, cardiopatía y diabetes [ 1 ].…”

“…Eikenella corrodens es un bacilo gramnegativo anaerobio facultativo, perteneciente a la familia Neisseriaceae , que forma parte de la microbiota normal de la cavidad oral, las vías respiratorias altas y la mucosa intestinal humana [ 1 ]. Raramente actúa como patógeno y sus infecciones suelen ser localizadas, aunque se han descrito casos invasivos en pacientes inmunodeprimidos o con otros factores de riesgo como manipulación quirúrgica de las vías aéreas, alcoholismo, drogadicción, cardiopatía y diabetes [ 1 ]. Debido a su relación con la orofaringe, una importante proporción de las infecciones están asociadas a mordedura humana [ 2 ], también se vincula con infecciones de cuello y cabeza y, en menor medida, con infecciones respiratorias o bacteriemias [ 3 ].…”

Bacteremia caused by Eikenella corrodens in a patient with pelvic inflammatory disease

“…However, the pathogenicity of the species has not to be overlooked as E. corrodens is one of the mayor actors driving the periodontal disease and other severe infections. The species was named after the ability to corrode the agar that up to 50% present [ 1 ]. Colonies have a characteristic bleach-like odor and might occasionally present a light alpha-hemolysis.…”

“…Periodontitis and opportunistic infections are frequently caused by E. corrodens , with a tendency to cause abscesses in very variate locations , but most frequently on the head and neck [ 1 - 3 ]. Although normally most infections are benign and indolent, invasive and recurrent infections, such perirenal abscesses, vertebral osteomyelitis or endocarditis have been reported; [ 4 - 6 ].…”