<i>Elizabethkingia miricola</i>: A rare non-fermenter causing urinary tract infection

Gupta, Parakriti; Zaman, Kamran; Mohan, Balvinder; Taneja, Neelam

doi:10.12998/wjcc.v5.i5.187

Cited by 33 publications

(24 citation statements)

References 8 publications

(13 reference statements)

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“…had a urinary stone or urinary neoplasms. Elizabethkingia was the second genus, and in 2017, a 25year-old woman was the first individual reported to have a UTI caused by Elizabethkingia and to have difficulty urinating [44]. On ground of our findings and previous reports, we assume that there is a strong association between obstructive UR and UTI, but it is not clear whether there is a causal relationship between them and what role microorganisms play.…”

Section: Discussionmentioning

confidence: 39%

Dysbiosis of urine microbiota in obstructive urinary retention patients revealed by next-generation sequencing

Jiang

Chen

et al. 2020

Preprint

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Background Urinary retention (UR) is a common urinary system disease can be caused by urinary tract obstruction with numerous reasons, however, the role of urine microbes in these disorders is still poorly understood. The aim of this study was to identify the urine microbial features of two common types of obstructive UR, caused by urinary stones or urinary tract tumors, with comparison to healthy controls. Methods Urine samples were collected from a cohort of 32 individuals with stone UR, 25 subjects with tumor UR and 25 healthy controls. The urine microbiome of all samples was analyzed using high-throughput 16S rRNA (16S ribosomal RNA) gene sequencing. Results We observed dramatically increased urine microbial richness and diversity in both obstructive UR groups compared to healthy controls. Despite different origins of UR, bacteria such as Pseudomonas, Acinetobacter and Sphingomonas were enriched, while Lactobacillus, Streptococcus, Gardnerella, Prevotella and Atopobium were decreased in both UR groups in comparison with healthy controls, exhibited an approximate urine microbial community and functional characteristics of two types of obstructive UR. Furthermore, disease classifiers were constructed using specific enriched genera in UR, which can distinguish stone UR or tumor UR patients from healthy controls with an accuracy of 92.29% and 97.96%, respectively. Conclusion We presented comprehensive microbial landscapes of two common types of obstructive urinary retention and demonstrated that urine microbial features of these patients are significantly different from that of healthy people. The urine microbial signatures would shed light on the pathogenesis of these types of urinary retention and might be used as potential classification tools in the future.

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Section: Discussionmentioning

confidence: 39%

Dysbiosis of urine microbiota in obstructive urinary retention patients revealed by next-generation sequencing

Jiang

Chen

et al. 2020

Preprint

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“…E . anophelis is also the etiologic agent of disease in healthcare associated outbreaks that have occurred in Illinois [ 48 ], the Central African Republic [ 49 ], Hong Kong [ 14 ], Taiwan [ 25 ], Singapore [ 36 ], and other isolated cases [ 23 , 28 , 33 , 40 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

et al. 2018

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We report the isolation and characterization of two Elizabethkingia anophelis strains (OSUVM-1 and OSUVM-2) isolated from sources associated with horses in Oklahoma. Both strains appeared susceptible to fluoroquinolones and demonstrated high MICs to all cell wall active antimicrobials including vancomycin, along with aminoglycosides, fusidic acid, chloramphenicol, and tetracycline. Typical of the Elizabethkingia, both draft genomes contained multiple copies of β-lactamase genes as well as genes predicted to function in antimicrobial efflux. Phylogenetic analysis of the draft genomes revealed that OSUVM-1 and OSUVM-2 differ by only 6 SNPs and are in a clade with 3 strains of Elizabethkingia anophelis that were responsible for human infections. These findings therefore raise the possibility that Elizabethkingia might have the potential to move between humans and animals in a manner similar to known zoonotic pathogens.

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“…Particularly, gene encoding products in the CU pathway were documented to be crucial for the urinary tract infection (58, 59), which is in line with the fact that multiple bacteria in Clade C and E (e.g. bacteria from genus Empedobacter and Elizabethkingia) are urinary infective pathogens (60,61). The ENP pathway is responsible for the curli production related to host (which was not certified by peer review) is the author/funder.…”

Section: Apibacter Lost Ancestral Gene Families Related To Pathogenicmentioning

confidence: 84%

Genomic features underlying the evolutionary transitions ofApibacterto honey bee gut symbionts

Zhang

et al. 2020

Preprint

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The symbiotic bacteria associated with honey bee gut have likely transformed from a free-living or parasitic lifestyle, through a close evolutionary association with the insect host. However, little is known about the genomic mechanism underlying bacterial transition to exclusive adaptation to the bee gut. Here we compared the genomes of bee gut symbionts Apibacter with their close relatives living in different lifestyles. We found that despite of general reduction in the Apibacter genome, genes involved in amino acid synthesis and monosaccharide detoxification were retained, which were likely beneficial to the host. Interestingly, the microaerobic Apibacter species have specifically acquired genes encoding for the nitrate respiration (NAR). The NAR system is also conserved in the cohabiting bee microbe Snodgrassella, although with a differed structure. This convergence implies a crucial role of respiratory nitrate reduction for microaerophilic microbiomes to colonize bee gut epithelium. Genes involved in lipid, histidine degradation are substantially lost in Apibacter, indicating a transition of the energy source utilization. Particularly, genes involved in the phenylacetate degradation to generate host toxic compounds, as well as other virulence factors were lost, suggesting the loss of pathogenicity. Antibiotic resistance genes were only sporadically distributed among Apibacter species, but condensed in their pathogenic relatives, which may be related to the remotely living feature and less exposure to antibiotics of their bee hosts. Collectively, this study advances our understanding of genomic transition underlying specialization in bee gut symbionts.

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Elizabethkingia miricola: A rare non-fermenter causing urinary tract infection

Cited by 33 publications

References 8 publications

Dysbiosis of urine microbiota in obstructive urinary retention patients revealed by next-generation sequencing

Dysbiosis of urine microbiota in obstructive urinary retention patients revealed by next-generation sequencing

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

Genomic features underlying the evolutionary transitions ofApibacterto honey bee gut symbionts

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