Enantio- and diastereoselective conjugate addition of pyridyl alkyl ketones to enones by Cu(ii)-Lewis acid/Brønsted base catalysis

Abstract

Cu(ii) Lewis acid/Brønsted base catalysis was employed to achieve enantio- and diastereoselective conjugate additions of pyridyl alkyl ketones to enones, resulting in the formation of various 1,5-diketones with vicinal stereocenters.