<i>Enterobacter cloacae</i> osteoarticular infection without risk factors: Case report and review of the literature

Yazidi, Laila S Al; Hameed, Hina; Isaacs, David; Axt, Matthias W.; Kesson, Alison

doi:10.1111/jpc.13908

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Si bien esta bacteria forma parte de la flora gastrointestinal humana, se la ha aislado en endoftalmitis, abscesos cerebrales, meningitis, espondilodiscitis y endocarditis. 10 El Enterobacter cloacae puede ser susceptible a a n t i b i ó t i c o s n o β -l a c t á m i c o s , c o m o fluoroquinolonas, cotrimoxazol, cloranfenicol y aminoglucósidos. Se considera resistente a las aminopenicilinas, cefalosporinas de primera generación y cefoxitina, debido a la presencia de β-lactamasas, con susceptibilidad variable a cefalosporinas de tercera y cuarta generación.…”

Section: Discussionunclassified

Abordaje interdisciplinario de endoftalmitis endógena neonatal. Reporte de caso

Osaba

Rivero²,

Canchi

et al. 2021

Arch Argent Pediat

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Presentación de casos clínicos RESUMEN La endoftalmitis endógena neonatal es una patología poco frecuente que puede causar daño ocular grave. Puede manifestarse en pacientes con comorbilidades, como nacimiento pretérmino, bajo peso al nacer, complicaciones posquirúrgicas perinatales o sepsis. El presente reporte de caso documenta a una paciente pretérmino que fue sometida a múltiples cirugías abdominales. Durante su internación, desarrolló sepsis, meningitis y endoftalmitis endógena neonatal. La frecuencia extremadamente baja de la endoftalmitis endógena a esta edad, la importancia de preservar la salud visual del paciente y el abordaje interdisciplinario son puntos importantes de aprendizaje en este caso.

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Section: Discussionunclassified

Abordaje interdisciplinario de endoftalmitis endógena neonatal. Reporte de caso

Osaba

Rivero²,

Canchi

et al. 2021

Arch Argent Pediat

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“…Infections with these pathogens are especially dangerous in immunocompromised patients, e.g., in solid organ transplant recipients on chronic immunosuppressive therapy [ 7 ] or in hemodialysis patients [ 8 ]. Enterobacter cloacae , the main representative of Enterobacter spp., colonizes the mucosa of the human intestine in a physiological state; however, it is also described as the source of many different disorders, including bacteremia [ 9 , 10 ], urinary tract infections (UTIs) [ 11 , 12 ], wound infections [ 13 , 14 , 15 ], osteoarticular infections [ 16 , 17 , 18 ], and pneumonia/lower respiratory tract infections [ 19 , 20 , 21 ]. These bacteria also commonly colonize in various hospital wards, including neonatal intensive care units, which may result in the development of life-threatening infections such as meningitidis [ 22 ].…”

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confidence: 99%

Two Newly Isolated Enterobacter-Specific Bacteriophages: Biological Properties and Stability Studies

Cieślik

Harhala

Orwat

et al. 2022

Viruses

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In an era of antibiotic therapy crisis caused by spreading antimicrobial resistance, and when recurrent urinary tract infections constitute a serious social and medical problem, the isolation and complex characterization of phages with a potential therapeutic application represents a promising solution. It is an inevitable, and even a necessary direction in the development of current phage research. In this paper, we present two newly isolated myoviruses that show lytic activity against multidrug-resistant clinical isolates of Enterobacter spp. (E. cloacae, E. hormaechei, and E. kobei), the genomes of which belong to a poorly represented phage group. Both phages were classified as part of the Tevenvirinae subfamily (Entb_43 was recognized as Karamvirus and Entb_45 as Kanagawavirus). Phage lytic spectra ranging from 40 to 60% were obtained. The most effective phage-to-bacteria ratios (MOI = 0.01 and MOI = 0.001) for both the phage amplification and their lytic activity against planktonic bacteria were also estimated. Complete adsorption to host cells were obtained after about 20 min for Entb_43 and 10 min for Entb_45. The phage lysates retained their initial titers even during six months of storage at both −70 °C and 4 °C, whereas storage at 37 °C caused a complete loss in their activity. We showed that phages retained their activity after incubation with solutions of silver and copper nanoparticles, which may indicate possible synergistic antibacterial activity. Moreover, a significant reduction in phage titers was observed after incubation with a disinfectant containing octenidinum dihydrochloridum and phenoxyethanol, as well as with 70% ethanol. The observed maintenance of phage activity during incubation in a urine sample, along with other described properties, may suggest a therapeutic potential of phages at the infection site after intravesical administration.

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Enterobacter cloacae infection of the shoulder in a 52-year-old woman without apparent predisposing risk factor: a case report and literature review

Huang

Liu

et al. 2021

BMC Infect Dis

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Background Enterobacter cloacae (E. cloacae) is one of the commensal flora in the human intestinal tract and a prevalent nosocomial pathogen, which rarely causes infectious osteoarthritis in immunocompetent patients without recent trauma or surgery. Here, we report the first case of septic monoarthritis of the shoulder caused by E. cloacae in an immunocompetent patient. Case presentation A 52-year-old female with a 6-year history of right shoulder pain was referred to our emergency department due to fever, acute severe shoulder pain, and swelling. Blood test showed elevated inflammatory markers. The patient denied any recent invasive surgical procedure and trauma. She was misdiagnosed with a frozen shoulder, and the anti-inflammatory painkiller celecoxib for symptomatic treatment was ineffective. Magnetic resonance imaging (MRI) showed a shoulder joint abscess and supraspinatus tendon tear. The joint aspirate culture showed E. cloacae. After late diagnosis, she was treated with levofloxacin and underwent surgical debridement and irrigation. Her follow-up data revealed that she did not suffer from shoulder swelling and severe pain. Conclusion This is a rare case of E. cloacae infected arthritis of the shoulder in an immunocompetent patient with a rotator cuff tear, indicating that even if the symptoms and age of the patients match the characteristics of frozen shoulder, the possibility of septic arthritis should be considered in the presence of fever and increasing inflammatory markers. The cases of our literature review suggest that the patients subjected to invasive procedure may develop a subsequent E. cloacae osteoarticular infection, regardless of being asymptomatic after the procedure.

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Enterobacter cloacae osteoarticular infection without risk factors: Case report and review of the literature

Cited by 3 publications

References 9 publications

Abordaje interdisciplinario de endoftalmitis endógena neonatal. Reporte de caso

Abordaje interdisciplinario de endoftalmitis endógena neonatal. Reporte de caso

Two Newly Isolated Enterobacter-Specific Bacteriophages: Biological Properties and Stability Studies

Enterobacter cloacae infection of the shoulder in a 52-year-old woman without apparent predisposing risk factor: a case report and literature review

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