Subdural Empyema is usually associated with paranasal sinusitis and otitis media/ mastoiditis. Posterior fossa subdural empyema is uncommon and late diagnosis is frequent. A 23-years-old male case with a posterior fossa subdural empyema associated with otitis media is reported. Emergent craniectomy, followed by a later stage tympanomastoidectomy, and long duration intravenous antibiotics were performed. Cultures revealed a polymicrobial infection. An ipsilateral temporal abscess occurred on a later stage and required multiple punctures for drainage. Due to brain temporal edema with mass effect, a decompressive craniectomy was required. Left-side hemiparesis was reverted with rehabilitation. Complete recovery was achieved with rightside hypoacusis. Magnetic resonance imaging is critical for diagnosis and follow-up. Surgical treatment englobes two stages: Empyema drainage and focus control -the first on an emergent basis, the second as soon as safely possible. Since subdural empyema is a severe condition, early diagnosis is essential to reduce morbidity and mortality.