2024
DOI: 10.1021/acs.orglett.4c02246
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Ex Situ Gaseous Reagent for Multicomponent Amine Bioconjugation

Yuxuan Ding,
Simon S. Pedersen,
Yixian Wang
et al.

Abstract: We report a minimalist gaseous sulfonyl-chloride-derived reagent for multicomponent bioconjugation with amine, phenol, or aniline reagents to afford urea or carbamate products. With the utilization of a gas-phase reagent for a reaction mediated by metal ions, a variety of biologically relevant molecules, such as saccharide, poly(ethylene glycol), fluorophore, and affinity tag, can be efficiently cross-linked to the N terminus or lysine side-chain amines on natural polypeptides or proteins.

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